治疗自闭症儿童硫胺素tetrahydrofurfuryl二硫化:一个试点研究。

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朗斯代尔D, Shamberger RJ Audhya T

治疗自闭症儿童硫胺素tetrahydrofurfuryl二硫化:一个试点研究。

神经性。2002年8月,23 (4):303 - 8。

PubMed ID

12195231 (在PubMed

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文摘

目的:初步研究,临床和生化的影响硫胺素tetrahydrofurfuryl二硫化(TTFD)自闭症儿童进行调查。对象和方法:十个孩子进行了研究。E2诊断证实了通过使用形式,计算机评估症状评分。出于实际的原因,TTFD管理连续两个月每天两次在直肠栓剂的形式,每个TTFD含有50毫克。症状反应测定通过使用计算机评估自闭症治疗评价检查表(ATEC)形式。红细胞转酮醇酶(TKA)和硫胺素焦磷酸的影响(TPPE),测量在一开始和完成研究文档的胞内硫胺素缺乏症。尿液从开始,患者检查后30天,60天的治疗后的浓度SH-reactive金属、总蛋白、硫酸盐、亚硫酸盐、硫代硫酸盐、硫氰酸测定。金属浓度的头发也被确定。结果:在研究的开始观察硫胺素缺乏症在3 10位病人。的患者中,6人最初的尿液样本中含有砷浓度高于健康对照组。 Traces of mercury were seen in urines from all of these autistic children. Following administration of TTFD an increase in cadmium was seen in 2 children and in lead in one child. Nickel was increased in the urine of one patient during treatment. Sulfur metabolites in urine did not differ from those measured in healthy children. CONCLUSIONS: Thiamine tetrahydrofurfuryl disulfide appears to have a beneficial clinical effect on some autistic children, since 8 of the 10 children improved clinically. We obtained evidence of an association of this increasingly occurring disease with presence of urinary SH-reactive metals, arsenic in particular.

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药物

硫胺素