探索开放标签,随机研究乙酰-和propionylcarnitine慢性疲劳综合症。

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Vermeulen RC,他人力资源

探索开放标签,随机研究乙酰-和propionylcarnitine慢性疲劳综合症。

Psychosom医学。2004;3 - 4月66 (2):276 - 82。

PubMed ID

15039515 (在PubMed

]

文摘

目标:我们acetylcarnitine的影响相比,propionylcarnitine和两个化合物慢性疲劳综合症(CFS)的症状。方法:在一个开放的、随机的方式我们2 g / d乙醯左旋肉碱相比,2 g / d propionyl-L-carnitine及其组合3组30 CFS患者在24周。被评为全球的印象改变临床效果。二次端点是多维疲劳库存,麦吉尔疼痛问卷,Stroop注意力集中测试。分数评估前8周治疗;在随机化;后8、16和24周的治疗;和2周后。结果:临床治疗后全球印象的变化显示相当大的改善acetylcarnitine组中59%的患者和63% propionylcarnitine组,但不acetylcarnitine + propionylcarnitine组(37%)。Acetylcarnitine显著提高精神疲劳(p = .015)和propionylcarnitine改善一般疲劳(p = 04)。 Attention concentration improved in all groups, whereas pain complaints did not decrease in any group. Two weeks after treatment, worsening of fatigue was experienced by 52%, 50%, and 37% in the acetylcarnitine, propionylcarnitine, and combined group, respectively. In the acetylcarnitine group, but not in the other groups, the changes in plasma carnitine levels correlated with clinical improvement. CONCLUSIONS: Acetylcarnitine and propionylcarnitine showed beneficial effect on fatigue and attention concentration. Less improvement was found by the combined treatment. Acetylcarnitine had main effect on mental fatigue and propionylcarnitine on general fatigue.

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药物

Acetylcarnitine