分子表征人类β3-adrenergic受体。
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Emorine LJ Marullo年代,Briend-Sutren MM,帕蒂克,他步行泰特K, Delavier-Klutchko C, Strosberg广告
分子表征人类β3-adrenergic受体。
科学。1989年9月8日,245(4922):1118 - 21所示。
- PubMed ID
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2570461 (在PubMed]
- 文摘
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自该项的分类(beta-ARs)β1和β2受体亚型,额外beta-ARs一直与儿茶酚胺的各种代谢过程的控制。人类基因被孤立,编码三分之一beta-AR,这里被称为“测试版”3-adrenergic受体。Exposure of eukaryotic cells transfected with this gene to adrenaline or noradrenaline promotes the accumulation of adenosine 3',5'-monophosphate; only 2 of 11 classical beta-AR blockers efficiently inhibited this effect, whereas two others behaved as beta 3-AR agonists. The potency order of beta-AR agonists for the beta 3-AR correlates with their rank order for stimulating various metabolic processes in tissues where atypical adrenergic sites are thought to exist. In particular, novel beta-AR agonists having high thermogenic, antiobesity, and antidiabetic activities in animal models are among the most potent stimulators of the beta 3-AR.