Alfaxalone麻醉绿鬣蜥(鬣蜥鬣蜥)。

文章的细节

引用

复制到剪贴板

Bertelsen MF,萨奥尔CD

Alfaxalone麻醉绿鬣蜥(鬣蜥鬣蜥)。

兽医Anaesth。2011年9月,38 (5):461 - 6。doi: 10.1111 / j.1467-2995.2011.00640.x。

PubMed ID

21831051 (在PubMed

]

文摘

目的:描述的麻醉效果alfaxalone管理肌内(IM) 10, 20日和30毫克公斤(1)。研究设计:前瞻性随机交叉研究。动物:十个少年绿鬣蜥(鬣蜥鬣蜥)的平均体重(+ / -标准差)480 + / - 134 g。方法:Alfaxalone管理我的肱三头肌胸四肢。次麻醉诱导、高原和恢复时间记录。骨骼肌的下巴,脖子,胸四肢、骨盆的四肢和尾巴是得分。睑,角膜和复原的反应,对疼痛刺激反应也被评估。脉搏和呼吸速率被记录了下来。比较不同剂量和随着时间的推移,使用方差分析。结果:乘以10,20和30毫克公斤(1)剂量分别为:平均最大时间效应为7.7 + / - 2.2,5.4 + / - 1.7和3.9 + / - 1.2分钟; duration of the plateau phase was 11.3 +/- 3.8, 22.1 +/- 6.5 and 39.1 +/- 11.5 minutes; recovery time was 10 +/- 2.4, 17.5 +/- 8.6 and 25 +/- 7.1 minutes; and total anaesthetic duration was 29 +/- 35.7, 45 +/- 8.2 and 68 +/- 9.8 inutes. Endotracheal intubation was possible in 40% of the subjects given 10 mg kg(-1) and in 100% subjects given both 20 and 30 mg kg(-1) . Loss of response to a painful stimulus was seen in 0/10, 8/10 and 9/10 animals at 10, 20, and 30 mg kg(-1) respectively. There was an initial dose-dependent depression of respiration followed by a significant increase in frequency over time. In contrast, pulse rates decreased by 20% over the duration of the anaesthetic events. CONCLUSIONS AND CLINICAL RELEVANCE: Intramuscular administration of alfaxalone is a simple, rapid and reliable means of achieving relatively brief sedation or anaesthesia in healthy green iguanas. A dosage of 10 mg kg(-1) provides light sedation, appropriate for examination and venipuncture; 20 mg kg(-1) provides a level suitable for minor procedures or for endotracheal intubation and supplementation with inhalational anaesthesia; 30 mg kg(-1) produces an anaesthetic plane suitable for surgical procedures of limited duration (up to 40 minutes).

beplay体育安全吗DrugBank数据引用了这篇文章

药物

Alfaxalone