性格动力学和组织残留的danofloxacin鸭。

文章的细节

引用

复制到剪贴板

Goudah Mouneir SM

性格动力学和组织残留的danofloxacin鸭。

Br幼禽Sci。2009年9月,50 (5):613 - 9。doi: 10.1080 / 00071660903147416。

PubMed ID

19904641 (在PubMed

]

文摘

1。处理动力学和等离子体的可用性在鸭danofloxacin单一静脉(注射)、肌内(坜)和口服政府5毫克/公斤体重。2。组织残留资料(肝、肾和肌肉)和等离子体也研究了多个肌肉和口服后5毫克/公斤连续5天每天一次。3所示。血浆和组织中的药物的浓度测定用高效液相色谱法(HPLC)与荧光检测样品收集在药品监督管理局后频繁的时间间隔。4所示。静脉注射后,血浆浓度与时间的曲线是最好的形容,二室开放模型。血浆药物浓度下降bi-exponential的半衰期(t (1/2alpha)) 0.08 h, (t (1/2beta)) 3.91 h分布和消除阶段,分别。5。 After intramuscular and oral administration of danofloxacin at the same dose the peak plasma concentrations (C(max)) were 0.89 and 0.81 microg/ml and attained at 1.17 and 1.21 h (T(max)), respectively, and the elimination half-lives (T(1/2el)) were 2.91 and 2.39 h, respectively. The systemic bioavailabilities were 103.21 and 89.26%, following i.m. and oral admisistartion, respectively. In vitro protein binding percent of danofloxacin in Muscovy ducks plasma was 17%. 6. The tissue level following i.m. and oral administration were highest in liver and kidney, respectively, and decreased in the following order: plasma and muscle. No danofloxacin residues were detected in tissues and plasma after 96 h with either route of administration except in liver and kidney, after 120 h in case of oral administration.

beplay体育安全吗DrugBank数据引用了这篇文章

药物

Danofloxacin