deracoxib或缓冲阿司匹林对胃黏膜的影响健康的狗。
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Sennello KA,莱布女士
deracoxib或缓冲阿司匹林对胃黏膜的影响健康的狗。
J兽医实习生地中海。2006;11 - 12月20 (6):1291 - 6。
- PubMed ID
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17186840 (在PubMed]
- 文摘
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背景:使用cyclo-oxygenase-2特定的非甾体类抗炎药物如deracoxib一直提倡,因为它们抗炎行动和明显的胃肠道不良反应发生率低。假说:Deracoxib将导致减少使用内窥镜检测胃损伤狗比阿司匹林,非选择性非甾体类抗炎药。动物:24随机源健康的狗。方法:一项随机、安慰剂对照试验相比gastroscopic发现的狗接受安慰剂(q8h),阿司匹林(25毫克/公斤PO q8h),或deracoxib(1.5毫克/公斤QD、安慰剂ql2h) 28天。胃镜检查在天7日6、14和28个评价胃的4个地区分别和可见的病变都得分。狗每8小时观察呕吐和腹泻。每天在每组的得分中值相比,内镜检查和总三伏天的呕吐和腹泻比较。意义是确定P < . 05。结果:总分有显著差异的阿司匹林组和安慰剂组和天deracoxib组织6日14日和28日。总分没有显著差异被发现与安慰剂deracoxib天6、14、28。 Significant differences in dog-days of vomiting were found between the aspirin and deracoxib groups whereas no significant differences were found between the deracoxib and placebo groups. There was no detectable effect of treatment on dog-days of diarrhea. CONCLUSIONS AND CLINICAL IMPORTANCE: Administration of deracoxib to healthy dogs resulted in significantly lower gastric lesion scores, and fewer days of vomiting compared to aspirin, indicating that deracoxib is better tolerated than aspirin in some dogs.
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- 药物