人类埋头轨迹的描述。
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Brauninger,圆锥形石垒T, Strebhardt K, Rubsamen-Waigmann H
人类埋头轨迹的描述。
致癌基因。1993;8 (5):1365 - 9。
- PubMed ID
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7683131 (在PubMed]
- 文摘
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CSK-gene编码一个细胞内酪氨酸蛋白激酶(PTK)。src-family成员相比,一个自身磷酸化网站对应Tyr416以及相当于监管Tyr527 p60c-src失踪的氨基酸序列推导出的基因。埋头磷酸化的酪氨酸激酶src-family的其他成员监管羧基端。通过调节这些激酶的活性,埋头可能扮演重要的角色在细胞生长和发展。在这里,我们描述人类埋头基因的结构。整个编码区跨越一个基因组的距离只有4.9 kb。它包含12个外显子介于66和220个基点。之间的内含子编码外显子76年至920年英国石油公司在不同长度。一个外显子编码的5 '非翻译区埋头分开第一编码外显子内含子的超过6400个基点。基于催化域内的序列同源性比较,细胞内ptk分为src-family,菲斯/拿来,abl / arg-group。 The genomic structure of four members of the SRC-family revealed nearly identical exon/intron boundaries within the catalytic domain of this family. They differ from those described for FES. Comparing the genomic structure of CSK with the exon/intron organisation of both, it is obvious that the exon/intron boundaries are in common either with those of the SRC-type or the FES boundaries. This intermediate exon/intron structure of CSK between FES and the SRC-family agrees with the position of CSK in a phylogenetic tree based on sequence homology within the kinase domain.