功效的maropitant推迟呕吐的预防与管理阿霉素的狗。

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劳,理发师LG,伯吉斯科

功效的maropitant推迟呕吐的预防与管理阿霉素的狗。

J兽医实习生地中海。2010;11 - 12月24 (6):1452 - 7。doi: 10.1111 / j.1939-1676.2010.0611.x。Epub 2010年10月12日。

PubMed ID

21039869 (在PubMed

]

文摘

背景:呕吐,恶心,食欲不振,腹泻是常见的延迟阿霉素的副作用。Maropitant neurokinin-1受体拮抗剂,是预防急性呕吐狗接受顺铂。摘要目的:评价maropitant防止延迟呕吐的疗效经过政府的阿霉素狗。动物:59狗与癌症。方法:随机、双盲、安慰剂对照研究使用交叉设计。狗被随机分为1 2治疗组。A组收到maropitant第一阿霉素后,第二后和安慰剂。B组接受安慰剂,maropitant第二。Maropitant(2毫克/公斤)或安慰剂药片服用阿霉素治疗后5天。业主完成视觉模拟尺度根据兽医合作肿瘤学Group-Common术语标准为不良事件等级宠物临床症状在一周后阿霉素。 Statistical differences in gastrointestinal toxicosis and myelosuppression between maropitant and placebo treatments were evaluated. RESULTS: Significantly fewer dogs had vomiting (P=.001) or diarrhea (P=.041), and the severity of vomiting (P<.001) and diarrhea (P=.024) was less the week after doxorubicin when receiving maropitant compared with placebo. No differences were found between maropitant and placebo for other gastrointestinal and bone marrow toxicoses. CONCLUSIONS AND CLINICAL IMPORTANCE: Maropitant is effective in preventing delayed vomiting induced by doxorubicin. Its prophylactic use might improve quality of life and decrease the need for dose reductions in certain dogs.

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药物

Maropitant