美托咪定-咪达唑仑绵羊镇静。
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Raekallio M, Tulamo RM, Valtamo T
美托咪定-咪达唑仑绵羊镇静。
兽医学报，1998;39(1):127-34。
- PubMed ID
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9592953 (PubMed视图］
- 摘要
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7只羊被麻醉3次:美托咪定(15微克kg-1)，咪达唑仑(0.1 mg kg-1)和药物联合使用。所有药物均经静脉注射。测量心脏和呼吸频率。采集动脉血样，测定PaO2、PaCO2、pH、血红蛋白浓度和饱和度以及碱过量。在美托咪定-咪达唑仑治疗前后记录收缩压和平均动脉压。咪达唑仑可增加美托咪定引起的卧位时间。单独服用咪达唑仑后，7只羊中4只镇静，另外3只兴奋。美托咪定和美托咪定-咪达唑仑均降低心率。一只绵羊在注射美托咪定咪达唑仑后心脏骤停，需要复苏。美托咪定后PaO2和血红蛋白氧饱和度下降，美托咪定-咪达唑仑引起明显低氧血症。 PaCO2 increased after medetomidine, both alone and combined with midazolam, but arterial pH was within the reference values after all drug administrations. Systolic and mean arterial pressures decreased after medetomidine-midazolam. This study indicates that though in sheep midazolam potentiates the sedative effect of medetomidine, the combination of medetomidine and midazolam also reduces the in PaO2 and haemoglobin oxygen saturation more than medetomidine alone. The results indicate that a medetomidine-midazolam combination is unsafe for sheep at the doses studied.
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