消除tilmicosin在哺乳期的母羊。

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Atef M, Abo血型el-Sooud K, Nahed E,陶菲克M

消除tilmicosin在哺乳期的母羊。

Dtsch Tierarztl Wochenschr。1999年7月,106 (7):291 - 4。

PubMed ID

10481373 (在PubMed

]

文摘

Tilmicosin哺乳期母羊一次皮下注射的剂量10毫克公斤b.wt。来确定它的等离子体、牛奶、尿液和瘤胃汁浓度。Tilmicosin可以检测到这些液体注入后30分钟。牛奶和尿液浓度高于血浆和瘤胃汁。牛奶中的药物检测、尿液和血浆为9,分别注射后4和3天。再多的tilmicosin以果汁可以检测到12小时后管理。tilmicosin在等离子体的平均浓度峰值和牛奶(Cmax)分别为1.29和9.5微克ml-1和获得(达峰时间)5.235和15.093小时,分别。药物慢慢消除从等离子体和牛奶的长半衰期(t1/2el) 15.4和26.2小时,分别。的意思是绑定tilmicosin等离子体和牛奶蛋白质体外是16.8%和26.8%,分别。药物在任何程度上并不一定要以果汁。 The rate of tilmicosin renal clearance revealed that it was correspondingly increased with higher blood concentrations. While creatinine clearance showed no significant change after tilmicosin administration. The ratio (fractional clearance) between tilmicosin renal clearance to creatinine clearance was less than one indicating that the glomerular filtration is the main pathway of elimination through kidneys. The rate of ruminal gas fermentation in ewes was inhibited after subcutaneous injection of tilmicosin at a dose of 10 mg kg-1 b.wt. The tested samples taken at different time intervals from the rumen of ewes showed a subsequent reduction in the rate of fermentation as compared to control samples. The reduction was correspondingly increased with the increase of tilmicosin concentration in ruminal juice and returned to normal thereafter.

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药物

Tilmicosin