体外活性difloxacin对犬类细菌隔离。

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van den胃气胀R,瓦格纳博士杰,沃克RD

体外活性difloxacin对犬类细菌隔离。

J兽医成岩作用投资。2000;12(3):218 - 23所示。

PubMed ID

10826834 (在PubMed

]

文摘

difloxacin的体外活性与犬类细菌分离株的临床病例研究在美国和荷兰。最低抑制浓度(MIC), postantibiotic效应,pH值对抗菌活性的影响,测定细菌杀灭率测试根据标准技术。美国和荷兰的中等收入国家隔离同意。中等收入国家的美国革兰氏阴性隔离范围从0.06到2.0 microg /毫升,和荷兰的麦克风革兰氏阴性隔离范围从0.016到8.0 microg /毫升。一些欧洲的变形杆菌和肺炎克雷伯菌相对较高的中等收入国家。博代氏杆菌属bronchiseptica容易difloxacin也少。中等收入国家的美国的革兰氏阳性球菌范围从0.125到4.0 microg /毫升,和荷兰的中等收入国家隔离范围从0.125到2.0 microg /毫升。Difloxacin诱导浓度postantibiotic效果持续了0.2 - 3小时与大肠杆菌文化,中间葡萄球菌,链球菌犬属、变形杆菌spp,肺炎克雷伯菌。没有postantibiotic效果观察犬铜绿假单胞菌。减少介质的pH值增加了difloxacin变形杆菌的麦克风。大肠杆菌和肺炎克雷伯菌的麦克风是最低在中性pH值和略增加酸或碱性介质。 At a neutral pH, most tested bacterial species were killed at a difloxacin concentration of 4 times the MIC. Similar results were obtained when these same bacteria were tested against enrofloxacin. A Klebsiella pneumoniae strain in an acidic environment was readily killed at difloxacin or enrofloxacin MIC, but at neutral pH the drug concentration had to be raised to 4 times the MIC for a bactericidal effect. After 24 hours of incubation at pH 7.1, difloxacin and enrofloxacin had similar bactericidal activity for all bacteria tested except Staphylococcus intermedius. Against S. intermedius, difloxacin was more bactericidal than enrofloxacin.

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药物

Difloxacin