合成前列腺素的性格和新陈代谢fluprostenol 81008 (ICI)的马。

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查普曼DI、苔藓女士,汤姆林森PW,哈里森MP,西蒙斯PJ

合成前列腺素的性格和新陈代谢fluprostenol 81008 (ICI)的马。

Xenobiotica。1980年9月,10(9):715 - 23所示。

PubMed ID

7445532 (在PubMed

]

文摘

1。以下单剂量肌内[14 c] fluprostenol(0.5 - 2.4毫克/千克)三个女马和三个阉割男性马、放射性出现在5分钟内等离子体;高峰用量。(0.32——1.30 ng / ml fluprostenol电化学当量)注射后发生5到90分钟。放射性仍出现在三天后雌性的等离子体。beplayapp大约88%的fluprostenol必将血浆蛋白。2。有放射性的腮腺唾液去势雄性马在10分钟。高峰用量。(45 - 91 pg / ml fluprostenol电化学当量)注射后发生从5分钟到1 h。唾液:等离子体用量。 ratios varied inversely with saliva flow rate and limiting ratios were 0.33 and 0.41 for the combined results of two experiments on each of two male horses; the calculated value is 0.46 Chromatography indicated that the majority of plasma and saliva radioactivity was [14C]fluprostenol. 3. Excretion of radioactivity in the urine was rapid and virtually complete 12 h after dosing. The total radioactivity excreted in urine by the female horses was 45% of the dose (96 h) and by the gelded male horses 53% (30 h). About 30% of the radioactivity present in the urines was unchanged fluprostenol. 4. Faecal excretion, which was substantially complete after 2 days, accounted for 32% of the radioactivity administered to the female horses. 5. Tissue conc. of radioactivity in the female horses at four days were below the limits of detection (90 pg/g), but 0.2--0.9% of the dose was detected at the site of injection.

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药物

Fluprostenol