组织莱克多巴胺残留的莱克多巴胺和尿排泄和代谢产物在动物与膳食莱克多巴胺治疗7天。

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史密斯DJ,搁置王

组织莱克多巴胺残留的莱克多巴胺和尿排泄和代谢产物在动物与膳食莱克多巴胺治疗7天。

J动物科学。2002年5月,80 (5):1240 - 9。

PubMed ID

12019611 (在PubMed

]

文摘

盐酸莱克多巴胺是一种该项leanness-enhancing代理最近被批准用于猪。组织中的莱克多巴胺损耗,消除莱克多巴胺及其代谢产物在尿液,检测感兴趣的标示外使用。本研究的目标是衡量肝脏和肾脏中的莱克多巴胺残留的牛(n = 6)、羊(n = 6),和鸭子(n = 9)治疗后饮食莱克多巴胺7(羊、鸭)或8(牛)连续几天并测量尿液的莱克多巴胺耗竭的牛羊。两个牛羊和三个鸭屠宰的撤军时间0 3和7 d。从牛羊每天收集尿液样本。使用监管组织莱克多巴胺浓度测定方法(FDA批准)莱克多巴胺在猪组织。莱克多巴胺残留的尿液样本测量之前和之后的轭合物的水解。分析液体后用荧光检测高效液相色谱——(水解样品)和(或)固相萃取。未发现残留在鸭组织。羊肝残留在平均24.0和2.6磅的0 -和3 d戒断期后,分别。羊肝残留在7 d撤军时间不到量化(2.5磅)的极限。 Sheep kidney residues were 65.1 and undetectable at 0- and at 3- and 7-d, withdrawal periods, respectively. Cattle liver residues were 9.3, 2.5, and undetectable after 0-, 3-, and 7-d withdrawal periods, respectively; kidney residues were 97.5, 3.4, and undetectable at the same respective withdrawal periods. Concentrations of parent ractopamine in sheep urine were 9.8+/-3.3 ppb on withdrawal d 0 and were below the LOQ (5 ppb) beyond the 2-d withdrawal period. After the hydrolysis of conjugates, ractopamine concentrations were 5,272+/-1,361 ppb on withdrawal d 0 and 178+/-78 ppb on withdrawal d 7. Ractopamine concentrations in cattle urine ranged from 164+/-61.7 ng/mL (withdrawal d 0) to below the LOQ (50 ppb) on withdrawal d 4. After the hydrolysis of conjugates in cattle urine, ractopamine concentrations were 4,129+/-2,351 ppb (withdrawal d 0) to below the LOQ (withdrawal d 6). These data indicate that after the hydrolysis of conjugates, ractopamine should be detectable in urine of sheep as long as 7 d after the last exposure to ractopamine and as long as 5 d after withdrawal in cattle.

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药物

莱克多巴胺