硬膜外管理tiletamine / zolazepam马。

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Natalini CC,阿尔维斯SD,古埃德AG) Polydoro, Brondani JT, Bopp年代

硬膜外管理tiletamine / zolazepam马。

兽医Anaesth。2004 4月,31 (2):79 - 85。

PubMed ID

15053744 (在PubMed

]

文摘

目的:评价镇痛、生理和行为影响的硬膜外管理tiletamine / zolazepam马。研究设计:前瞻性,双盲,随机试验研究。动物:五成人健康的马10到16岁,体重(意思是+ / - SD) 400 + / - 98公斤。方法:镇静与马1.0毫克公斤(1)静脉注射(IV)甲苯噻嗪,和一个硬膜外导管放入第一intercoccygeal椎间空间。48小时后休息期间,硬膜外tiletamine / zolazepam 0.5毫克公斤(1)(我)治疗或1.0毫克公斤(1)(治疗II),稀释到5毫升无菌水,是管理1周治疗之间的时间间隔。动脉血压、心率、呼吸率、和镇静评估。为了评估呼吸作用,血液从颈动脉被撤回0时刻(基线),然后在60 - 240分钟。镇痛是评估通过应用有害刺激与blunt-tipped钳会阴区域,和分级完成,温和,或缺席。数据收集前tiletamine / zolazepam政府每隔15分钟和120分钟,4小时后tiletamine / zolazepam管理。数据分析与方差分析和Bonferroni与p < 0.05的测试。 RESULTS: The results showed no significant difference between treatments in cardiovascular and respiratory measurements. Sedation was observed with both doses, and it was significantly different from baseline at 60, 75, and 90 minutes in treatment II. Moderate analgesia and locomotor ataxia were observed with both the treatments. CONCLUSIONS AND CLINICAL RELEVANCE: The results suggest that caudal epidural 0.5 and 1.0 mg kg(-1) tiletamine/zolazepam increases the threshold to pressure stimulation in the perineal region in horses. The use of epidural tiletamine/zolazepam could be indicated for short-term moderate epidural analgesia. There are no studies examining spinal toxicity of Telazol, and further studies are necessary before recommending clinical use of this technique.

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药物

Tiletamine

Zolazepam