NAV

Ammonium lactate

Identification

Summary

Ammonium lactateis an inorganic compound used for the symptomatic treatment of dry, scaly skin (xerosis) and ichthyosis vulgaris and for temporary relief of itching associated with these conditions.

Brand Names
Lac-hydrin, Ultravate X Ointment
Generic Name
Ammonium lactate
DrugBank Accession Number
DB06768
Background

Ammonium lactate is the ammonium salt of lactic acid.

Type
Small Molecule
Groups
Approved
Structure
MOL SDF PDB SMILES InChI
Similar Structures
Weight
Average: 107.1085
Monoisotopic: 107.058243159
Chemical Formula
C3H9NO3
Synonyms
  • Ammonium (+-)-lactate
  • Ammonium lactate
  • Lactic acid ammonium salt
External IDs
  • E328

Pharmacology

Indication

For the treatment of dry, scaly skin (xerosis) and ichthyosis vulgaris and for temporary relief of itching associated with these conditions.

Reduce drug development failure rates
Build, train, & validate machine-learning models
with evidence-based and structured datasets.
See how
Build, train, & validate predictive machine-learning models with structured datasets.
See how
Associated Conditions
Contraindications & Blackbox Warnings
Avoid life-threatening adverse drug events
Improve clinical decision support with information oncontraindications & blackbox warnings, population restrictions, harmful risks, & more.
Learn more
Avoid life-threatening adverse drug events & improve clinical decision support.
Learn more
Pharmacodynamics

Lactic acid is an alpha-hydroxy acid. It is a normal constituent of tissues and blood. The alpha-hydroxy acids (and their salts) may act as humectants when applied to the skin. This property may influence hydration of the stratum corneum. In addition, lactic acid, when applied to the skin, may act to decrease corneocyte cohesion.

Mechanism of action

Unknown.

Absorption

In vitro study of percutaneous absorption of ammonium lactate lotion, 12% using human cadaver skin indicates that approximately 5.8% of the material was absorbed after 68 hours.

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Improve decision support & research outcomes
With structured adverse effects data, including:blackbox warnings, adverse reactions, warning & precautions, & incidence rates.
Learn more
Improve decision support & research outcomes with our structured adverse effects data.
Learn more
Toxicity

口服一个dministration of Lac-Hydrin to rats and mice showed this drug to be practically non-toxic (LD50 > 15 mL/kg).

Pathways
Not Available
Pharmacogenomic Effects/ADRsBrowse all" title="" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">
Not Available

Interactions

Drug InteractionsLearn More" title="" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
No interactions found.

Products

Drug product information from 10+ global regions
Our datasets provide approved product information including:
dosage, form, labeller, route of administration, and marketing period.
Access now
Access drug product information from over 10 global regions.
Access now
Active Moieties
Name Kind UNII CAS InChI Key
Lactic acid unknown 3B8D35Y7S4 50-21-5 JVTAAEKCZFNVCJ-UHFFFAOYSA-N
International/Other Brands
Amlactin
Brand Name Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image
Lac Hydrin Cream Cream 120 mg/1g Topical Sun Pharmaceutical Industries, Inc. 2009-03-16 2014-02-28 US flag
Lac-Hydrin Lotion 120 mg/1g Topical 医生总保健公司。 2008-08-15 2012-06-30 US flag
Lac-Hydrin Lotion 120 mg/1g Topical Sun Pharmaceutical Industries Limited 2008-08-15 2008-08-15 US flag
Lac-Hydrin Lotion 120 mg/1g Topical Ranbaxy, Inc 2008-01-28 Not applicable US flag
Lac-Hydrin Cream 120 mg/1g Topical Bristol Myers Squibb Pharma Company 2009-06-01 2012-10-15 US flag
Generic Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image
Ammonium Lactate Cream 12 g/100g Topical bryant ranch prepack 2006-08-16 Not applicable US flag
Ammonium Lactate Lotion 12 g/100g Topical Actavis Pharma, Inc. 2012-06-05 2016-06-30 US flag
Ammonium Lactate Cream 12 g/100g Topical REMEDYREPACK INC. 2019-11-25 Not applicable US flag
Ammonium Lactate Lotion 12 g/100g Topical 医生总保健公司。 2002-02-14 Not applicable US flag
Ammonium Lactate Cream 12 g/100g Topical bryant ranch prepack 2006-08-16 Not applicable US flag
Ammonium Lactate Lotion 12 g/100g Topical bryant ranch prepack 2006-06-20 Not applicable US flag
Ammonium Lactate Cream 120 mg/1g Topical Paddock Laboratories, Inc. 2006-02-07 2012-03-31 US flag
Ammonium Lactate Lotion 120 mg/1g Topical Taro Pharmaceuticals U.S.A., Inc. 2004-05-28 Not applicable US flag
Ammonium Lactate Cream 120 mg/1g Topical Goldline Laboratories, Inc. 2009-02-28 2009-03-01 US flag
Ammonium Lactate Lotion 12 g/100g Topical Padagis Israel Pharmaceuticals Ltd 2006-06-20 Not applicable US flag
Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image
Ammonium Lactate Lotion 17 g/1g Topical Nnodum Pharmaceuticals 2007-12-30 Not applicable US flag
Ammonium Lactate Cream 17 g/1g Topical Nnodum Pharmaceuticals 2007-12-30 Not applicable US flag
Geri-Hydrolac Lotion 12 g/100g Topical GERITREX CORP 2013-05-10 Not applicable US flag
Geri-Hydrolac Cream 12 g/100g Topical GERITREX CORP 2013-06-25 Not applicable US flag
Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image
Quinosone Ammonium lactate(120 mg/1g)+Mometasone furoate(1 mg/1g) Kit Topical V2 Pharma, LLC 2019-06-03 Not applicable US flag
Ultravate X Ammonium lactate(100 mg/1g)+Ulobetasol propionate(0.5 mg/1g) Kit Topical Sun Pharmaceutical Industries, Inc. 2012-07-09 2017-08-31 US flag
Ultravate X Ammonium lactate(100 mg/1g)+Ulobetasol propionate(0.50 mg/1g) Kit Topical Ranbaxy Inc. 2012-07-01 Not applicable US flag

Categories

Drug Categories
Chemical TaxonomyProvided byClassyfire
Description
This compound belongs to the class of organic compounds known as carboxylic acid salts. These are ionic derivatives of carboxylic acid.
Kingdom
Organic compounds
Super Class
Organic acids and derivatives
Class
Carboxylic acids and derivatives
Sub Class
Carboxylic acid derivatives
Direct Parent
Carboxylic acid salts
Alternative Parents
二级醇/Monocarboxylic acids and derivatives/Carboxylic acids/Organic zwitterions/Organic salts/Organic oxides/Organic nitrogen compounds/Hydrocarbon derivatives/Carbonyl compounds
Substituents
Alcohol/Aliphatic acyclic compound/Carbonyl group/Carboxylic acid/Carboxylic acid salt/Hydrocarbon derivative/Monocarboxylic acid or derivatives/Organic nitrogen compound/Organic oxide/Organic oxygen compound
Molecular Framework
Aliphatic acyclic compounds
外部描述符
Not Available
Affected organisms
  • Humans and other mammals

Chemical Identifiers

UNII
67M901L9NQ
CAS number
515-98-0
InChI Key
RZOBLYBZQXQGFY-UHFFFAOYSA-N
InChI
InChI=1S/C3H6O3.H3N/c1-2(4)3(5)6;/h2,4H,1H3,(H,5,6);1H3
IUPAC Name
ammonium 2-hydroxypropanoate
SMILES
[NH4+].CC(O)C([O-])=O

References

一般References
Not Available
Human Metabolome Database
HMDB0015671
KEGG Drug
D02920
PubChem Compound
62358
PubChem Substance
175427089
ChemSpider
56149
RxNav
215247
ChEMBL
CHEMBL1200747
PharmGKB
PA165958400
Wikipedia
Ammonium_lactate
FDA label
Download (14.2 KB)
MSDS
Download (46.8 KB)

Clinical Trials

Clinical TrialsLearn More" title="" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">
Phase Status Purpose Conditions Count
4 Completed 治疗 Psoriasis Vulgaris (Plaque Psoriasis) 1
4 Completed 治疗 Stable Plaque Psoriasis 1
3 Completed 治疗 Dry Skin 1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Form Route Strength
Cream Topical 12 g/100g
Cream Topical 120 mg/1g
Cream Topical 17 g/1g
Lotion Topical 12 g/100g
Lotion Topical 17 g/1g
Lotion Topical 120 mg/1g
Kit Topical
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
Property Value Source
Water Solubility 866.0 mg/mL ALOGPS
logP -0.51 ALOGPS
logP -0.47 Chemaxon
logS 0.91 ALOGPS
pKa (Strongest Acidic) 3.78 Chemaxon
pKa (Strongest Basic) -3.7 Chemaxon
Physiological Charge -1 Chemaxon
Hydrogen Acceptor Count 3 Chemaxon
Hydrogen Donor Count 1 Chemaxon
Polar Surface Area 60.36 Å2 Chemaxon
Rotatable Bond Count 1 Chemaxon
Refractivity 29.68 m3·mol-1 Chemaxon
Polarizability 7.65 Å3 Chemaxon
Number of Rings 0 Chemaxon
Bioavailability 1 Chemaxon
Rule of Five Yes Chemaxon
Ghose Filter No Chemaxon
Veber's Rule No Chemaxon
MDDR-like Rule No Chemaxon
Predicted ADMET Features
Property Value Probability
Human Intestinal Absorption + 0.7873
Blood Brain Barrier + 0.7656
Caco-2 permeable - 0.7876
P-glycoprotein substrate Non-substrate 0.7911
P-glycoprotein inhibitor I Non-inhibitor 0.9869
P-glycoprotein inhibitor II Non-inhibitor 0.9581
Renal organic cation transporter Non-inhibitor 0.952
CYP450 2C9 substrate Non-substrate 0.8121
CYP450 2D6 substrate Non-substrate 0.9016
CYP450 3A4 substrate Non-substrate 0.7749
CYP450 1A2 substrate Non-inhibitor 0.9606
CYP450 2C9 inhibitor Non-inhibitor 0.9147
CYP450 2D6 inhibitor Non-inhibitor 0.9687
CYP450 2C19 inhibitor Non-inhibitor 0.9614
CYP450 3A4 inhibitor Non-inhibitor 0.9755
CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.9734
Ames test Non AMES toxic 0.9357
Carcinogenicity Non-carcinogens 0.5528
Biodegradation Ready biodegradable 0.9862
Rat acute toxicity 1.5255 LD50, mol/kg Not applicable
hERG inhibition (predictor I) Weak inhibitor 0.986
hERG inhibition (predictor II) Non-inhibitor 0.9698
ADMET data is predicted usingadmetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
Spectrum Spectrum Type Splash Key
Predicted GC-MS Spectrum - GC-MS Predicted GC-MS Not Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS Not Available

药物在9月tember 14, 2010 16:21 / Updated at February 21, 2021 18:52