NAV

Valethamate

This drug entry is astuband has not been fully annotated. It is scheduled to be annotated soon.

Identification

Summary

Valethamateis an anticholinergic medication used to symptomatically manage conditions involving smooth muscle spasms including spastic constipation, dysmenorrhea, and gastrointestinal tract cramping.

Generic Name
Valethamate
DrugBank Accession Number
DB13497
Background

Not Available

Type
Small Molecule
Groups
Experimental
Structure
 3D
Similar Structures
Weight
Average: 306.469
Monoisotopic: 306.242755695
Chemical Formula
C19H32NO2
Synonyms
Not Available

Pharmacology

Indication

Not Available

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Associated Conditions
Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

间隙

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRsBrowse all" title="" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">
Not Available

Interactions

Drug InteractionsLearn More" title="" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

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Product Ingredients
Ingredient UNII CAS InChI Key
Valethamate bromide 6XFR940M2A 90-22-2 CEJGGHKJHDHLAZ-UHFFFAOYSA-M
Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image
EPIDOSIN COMPOSITUM 10 MG AMPUL, 3 ADET Valethamate bromide(10 mg)+Acetaminophen(325 mg) Solution RECORDATİ İLAÇ SAN. VE TİC. A.Ş. 2020-08-14 Not applicable Turkey flag
EPIDOSIN COMPOSITUM ÇOCUKLARA, 5 ADET Valethamate bromide(10 mg)+Acetaminophen(325 mg) Solution RECORDATİ İLAÇ SAN. VE TİC. A.Ş. 2020-08-14 Not applicable Turkey flag
EPIDOSIN COMPOSITUM DRAJE Valethamate bromide(10 mg)+Acetaminophen(325 mg) Tablet, coated RECORDATİ İLAÇ SAN. VE TİC. A.Ş. 2020-08-14 Not applicable Turkey flag

Categories

ATC Codes
A03AX14 — Valethamate
Drug Categories
Chemical TaxonomyProvided byClassyfire
Description
This compound belongs to the class of organic compounds known as phenylpropanes. These are organic compounds containing a phenylpropane moiety.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Benzene and substituted derivatives
Sub Class
Phenylpropanes
Direct Parent
Phenylpropanes
Alternative Parents
Fatty acid esters/Tetraalkylammonium salts/Carboxylic acid esters/Monocarboxylic acids and derivatives/Organopnictogen compounds/Organic salts/Organic oxides/Hydrocarbon derivatives/Carbonyl compounds/Amines
show 1 more
Substituents
Amine/Aromatic homomonocyclic compound/Carbonyl group/Carboxylic acid derivative/Carboxylic acid ester/Fatty acid ester/Fatty acyl/Hydrocarbon derivative/Monocarboxylic acid or derivatives/Organic cation
show 10 more
Molecular Framework
Aromatic homomonocyclic compounds
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
D64S64QVX7
CAS number
16376-74-2
InChI Key
UPPMZCXMQRVMME-UHFFFAOYSA-N
InChI
InChI=1S/C19H32NO2/c1-6-16(4)18(17-12-10-9-11-13-17)19(21)22-15-14-20(5,7-2)8-3/h9-13,16,18H,6-8,14-15H2,1-5H3/q+1
IUPAC Name
diethyl(methyl){2-[(3-methyl-2-phenylpentanoyl)oxy]ethyl}azanium
SMILES
CCC(C)C(C(=O)OCC[N+](C)(CC)CC)C1=CC=CC=C1

References

General References
  1. TITCK Product Information: Epimol (valethamate bromide) solution for injection [Link]
  2. National Center for Advancing Translational Sciences: Valethamate [Link]
ChemSpider
5446
ChEBI
135303
ChEMBL
CHEMBL2111176

Clinical Trials

Clinical TrialsLearn More" title="" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">
Phase Status Purpose Conditions Count

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Form Route Strength
Tablet, coated 10 mg
Tablet 10 mg
Tablet 20 mg
Injection Intramuscular; Intravenous 8 mg
Solution
Tablet, coated
Injection, solution Intramuscular; Intravenous 8 mg/ml
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
Property Value Source
Water Solubility 6.57e-05 mg/mL ALOGPS
logP 0.26 ALOGPS
logP 0.046 Chemaxon
logS -6.7 ALOGPS
pKa (Strongest Basic) -7.1 Chemaxon
Physiological Charge 1 Chemaxon
Hydrogen Acceptor Count 1 Chemaxon
Hydrogen Donor Count 0 Chemaxon
Polar Surface Area 26.3 Å2 Chemaxon
Rotatable Bond Count 10 Chemaxon
Refractivity 103.89 m3·mol-1 Chemaxon
Polarizability 36.55 Å3 Chemaxon
Number of Rings 1 Chemaxon
Bioavailability 1 Chemaxon
Rule of Five Yes Chemaxon
Ghose Filter Yes Chemaxon
Veber's Rule Yes Chemaxon
MDDR-like Rule No Chemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Spectrum Spectrum Type Splash Key
Predicted GC-MS Spectrum - GC-MS Predicted GC-MS Not Available

Drug created at June 23, 2017 20:43 / Updated at May 14, 2021 01:06