卡维地洛能防止心脏肥大和过度的低氧factor-1alpha pressure-overloaded鼠心脏血管内皮生长因子。
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害羞的公斤来说,Liou司法院,王BW,方WJ, Chang H
卡维地洛能防止心脏肥大和过度的低氧factor-1alpha pressure-overloaded鼠心脏血管内皮生长因子。
J生物医学科学。2005;12 (2):409 - 20。
- PubMed ID
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15942707 (在PubMed]
- 文摘
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β受体阻断剂的使用已经成为一个有益的治疗心脏肥大。低氧factor-1alpha (HIF-1alpha)心室心肌的严格监管。然而,HIF-1alpha的表达在心脏肥大由于压力过载和β受体阻滞剂治疗后却鲜为人知。卡维地洛对心肌的影响评估HIF-1alpha表达式和心脏肥大,infra-renal主动脉条带进行4周的成年老鼠Sprague-Dawley诱导心脏肥大。卡维地洛在手术后50毫克/公斤体重/天。心脏重量和心脏重量和体重的比值显著增加主动脉带4周后没有药物治疗。平均动脉压增加从80 + / - 9毫米汞柱骗局组94 + / 5毫米汞柱联合组(p < 0.001)。超声心动图显示主动脉分班后同心肥大。用卡维地洛治疗后平均动脉压下降。增加壁厚和心脏重量被卡维地洛逆转正常。 Western blot showed that HIF-1alpha, vascular endothelial growth factor (VEGF) and brain natriuretic peptide (BNP) proteins were up-regulated and nerve growth factor-beta (NGF-beta) down-regulated in the banding group. Treatment with valsartan, doxazosin, or N-acetylcysteine did not significantly affect HIF-1alpha and VEGF proteins expression in the banding groups. Real-time polymerase chain reaction showed that mRNA of HIF-1alpha, VEGF and BNP increased and mRNA of NGF-beta decreased in the banding group. Treatment with carvedilol reversed both protein and mRNA of HIF-1alpha, VEGF, BNP, and NGF-beta to the baseline values. Increased immunohistochemical labeling of HIF-1alpha, VEGF, and BNP in the ventricular myocardium was observed in the banding group and carvedilol again normalized the labeling. In conclusion, HIF-1alpha, VEGF, and BNP mRNA and protein expression were up-regulated, while NGF-beta mRNA and protein was downregulated in the rat model of pressure-overloaded cardiac hypertrophy. Treatment with carvedilol is associated with a reversal of abnormal regulation of HIF-1alpha, VEGF, BNP, and NGF-beta in the hypertrophic myocardium.