脱氢表雄酮治疗的女性都有轻度到中度的系统性红斑狼疮:一项多中心随机、双盲、安慰剂对照试验。

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罗Chang DM、局域网JL林HY,科幻小说

脱氢表雄酮治疗的女性都有轻度到中度的系统性红斑狼疮:一项多中心随机、双盲、安慰剂对照试验。

关节炎感冒。2002年11月,46 (11):2924 - 7。

PubMed ID
12428233 (在PubMed
]
文摘

摘要目的:评价疗效和耐受性的脱氢表雄酮(DHEA) 200毫克/天的剂量在成年女性活跃的系统性红斑狼疮(SLE)。方法:在一个多中心随机、双盲、安慰剂对照试验,120名成年女性活跃的系统性红斑狼疮接受口服脱氢表雄酮(200毫克/天;n = 61)或安慰剂(n = 59) 24周。主要终点是均值变化从系统性红斑狼疮活动的基线测量(大满贯)得分在24周的治疗。次要终点包括第一弹,变化在系统性红斑狼疮疾病活动指数(咽部)得分,医生和病人的全球评估分数在24周。结果:两组均衡的基线特征。意味着减少大满贯成绩从基线相似,治疗组在统计学上没有显著性差异(脱氢表雄酮-2.6 + / - 3.4与安慰剂-2.0 + / - 3.8,意味着+ / - SD)。耀斑的患者的数量下降了16%在脱氢表雄酮组(DHEA-treated患者和33.9%的安慰剂治疗患者的18.3%;P = 0.044,基于时间第一个耀斑)。均值变化在病人的全球评估两组之间有统计学显著性(脱氢表雄酮-5.5与安慰剂5.4; P = 0.005). The number of patients with serious adverse events, most of which were related to SLE flare, was significantly lower in DHEA-treated patients compared with placebo-treated patients (P = 0.010). Expected hormonal effects, including increased testosterone levels and increased incidence of acne, were observed. No life-threatening reactions or serious safety issues were identified during this study. CONCLUSION: The overall results confirm that DHEA treatment was well-tolerated, significantly reduced the number of SLE flares, and improved patient's global assessment of disease activity.

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