Zaleplon:回顾其使用治疗失眠。

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Dooley M, Plosker GL

Zaleplon:回顾其使用治疗失眠。

药。2000年8月,60 (2):413 - 45。

PubMed ID

10983740 (在PubMed

]

文摘

Zaleplon pyrazolopyrimidine催眠剂是表示在短期内(2到4周)管理的失眠。Zaleplon睡前5和10毫克(常规推荐剂量)显著减少睡眠潜伏期与安慰剂比较的临床试验在老年患者和老年人失眠。一般来说,睡眠维护(无语问苍天的睡眠时间和数量)和睡眠质量没有显著不同于安慰剂zaleplon 5和10毫克/晚上。Zaleplon 20毫克/显著提高睡眠延迟和持续时间在老年患者中,但影响醒来的数量不一致,睡眠质量一般没有改善。的相对催眠功效zaleplon相比的三唑仑和唑吡坦尚不明确。宽容的催眠影响zaleplon一般不发生在5周的治疗,或在长期治疗(6或12个月)根据少量的研究摘要。Zaleplon容忍在临床试验中。最常见的事件是头痛,但发生率与安慰剂相似观察。Zaleplon 5和10毫克甚至没有损害精神运动功能或内存后立即剂量研究志愿者或失眠患者。然而Zaleplon 20毫克,精神运动功能受损和内存后立即剂量但第二天影响并没有观察到。 The psychomotor profile of zaleplon appears to be better than that of comparator agents. Rebound insomnia was not observed after sudden discontinuation of up to 12 months' treatment with zaleplon 5 and 10 mg/night and up to 4 weeks' treatment with zaleplon 20 mg/night. In addition, the potential for withdrawal syndrome with zaleplon appears to be low according to limited data. In conclusion, zaleplon 5, 10 and 20 mg administered at bedtime, or later if patients have difficulty sleeping, is an effective and well tolerated hypnotic agent. There was no evidence of next-day residual effects with the 5 and 10 mg dosages, and the incidence of withdrawal effects with zaleplon 5, 10 and 20 mg did not differ significantly to that observed with placebo. In addition, tolerance to the effects of zaleplon is unlikely to develop when administered for the recommended treatment period. The comparative efficacy and tolerability of zaleplon with other short acting nonbenzodiazepine hypnotics is difficult to establish. However, on the basis of current efficacy evidence and the lower incidence of residual effects with zaleplon 5 and 10 mg relative to comparator agents, this drug represents a useful option in the management of patients with insomnia who have difficulties initiating sleep.

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药物

Zaleplon