增加多巴胺能和5-hydroxytryptaminergic活动在雄性大鼠大脑长期治疗后合成雄激素类固醇。

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Thiblin我,芬恩,罗斯某人,Stenfors C

增加多巴胺能和5-hydroxytryptaminergic活动在雄性大鼠大脑长期治疗后合成雄激素类固醇。

Br J杂志。1999年3月,126 (6):1301 - 6。

PubMed ID

10217522 (在PubMed

]

文摘

1。用四个不同的治疗组大鼠的影响(AAS)的合成雄激素类固醇(睾丸激素,诺龙,methandrostenolone oxymetholone)对5 -羟色胺(5 -)和多巴胺(DA)神经元在大脑不同区域检查。原子吸收光谱法是六次注射1周的间隔和老鼠最后牺牲了2天后注入。5及其代谢物5-hydroxyindoleacetic酸(5-HIAA), DA及其代谢物3 4-dihydroxyphenylacetic酸(DOPAC)和高香草酸(HVA)测量。对DA和5的合成速率的影响被分析为3的积累,4-dihydroxyphenyl-alanine(多巴)和5-hydroxytryptophan (5-HTP),分别与nsd氨基酸脱羧酶的抑制后- 1015 (3-hydroxy-benzylhydrazine盐酸盐)。此外,单胺氧化酶(MAO)活性在下丘脑分析。2。DOPAC + HVA / DA比率增加纹状体中所有治疗组。然而,合成率达只methandrostenolone治疗组显著增加。3所示。 The 5-HIAA/5-HT ratio was increased in all treatment groups in the hippocampus, in the frontal cortex in the methandrostenolone-treated animals and in the hypothalamus in the testosterone- and oxymetholone-treated rats, while the 5-HT synthesis rate was not affected by the AAS-treatments. 4. The MAO-A activity was increased in the oxymetholone-treated rats while the other treatment groups were unaffected. The MAO-B activity was not changed. 5. The results indicate that relatively high doses of AAS increase dopaminergic and 5-hydroxytryptaminergic metabolism in male rat brain, probably due to enhanced turnover in these monaminergic systems.

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药物酶

药物	酶	类	生物	药理作用	行动
Oxymetholone	胺氧化酶(flavin-containing)	蛋白质	人类	未知的	诱导物	细节