高压氧提高效率5-aminosalicylic酸在大鼠乙酸段结肠炎。
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Gorgulu年代,Yagci G, Kaymakcioglu N, Ozkara M,库尔特·B, Ozcan,岩石O, Sadir年代,猛烈的风暴T
高压氧提高效率5-aminosalicylic酸在大鼠乙酸段结肠炎。
挖说科学。2006年3月,51 (3):480 - 7。
- PubMed ID
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16614956 (在PubMed]
- 文摘
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本研究的目的是评估高压氧的效率,结合5-aminosalicylic酸乙酸段结肠炎模型中,一个著名的实验模型大鼠的炎症性肠病。老鼠被随机分为五组。noncolitis对照组,老鼠等渗盐水,而其他组老鼠被intracolonic政府4%的醋酸。在组2,未经处理的对照组,没有额外的治疗应用。组3、4和5高压氧,5-aminosalicylic酸。和5-aminosalicylic酸+高压氧疗法是应用,分别。政府的醋酸在所有动物引起炎症反应。组织病理组2的得分显著高于其他组。5-Aminosalicylic酸和高压氧显著降低病理评分(P < 0.05)。髓过氧化物酶活性也显著减少了5-aminosalicylic酸(P < 0.05),但不是高压氧。 The most prominent ameliorative effect, however, was seen in group 5 and the histopathologic score and myeloperoxidase activity were significantly lower than in groups 3 (P < 0.05) and 4 (P < 0.001). Hydroxyproline level also increased significantly in group 5, but not in groups 3 and 4 (P < 0.001). These findings indicate that hyperbaric oxygen therapy is effective in reducing the extent of colitis induced by acetic acid, although it is not as potent as 5-aminosalicylic acid. The combination of hyperbaric oxygen and 5-aminosalicylic acid, however, led to a much more prominent reduction in the severity of colitis. Hyperbaric oxygen may have a promising place in the treatment of inflammatory bowel disease.