在急性,单用奎硫平治疗广泛性焦虑障碍:随机对照试验的系统性回顾和荟萃分析。

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Maneeton N, Maneeton B, Woottiluk P, Likhitsathian年代,Suttajit年代,Boonyanaruthee V, Srisurapanont M

在急性,单用奎硫平治疗广泛性焦虑障碍:随机对照试验的系统性回顾和荟萃分析。

药物洗脱支架重击。2016年1月12日;10:259 - 76。doi: 10.2147 / DDDT.S89485。eCollection 2016。

PubMed ID

26834458 (在PubMed

]

文摘

背景:一些研究表明喹硫平的疗效治疗广泛性焦虑障碍(GAD)。摘要目的:本研究的目的是系统地复习效果,奎硫平在成人患者的可接受性和耐受性。迦得。方法:斯高帕斯、MEDLINE、CINAHL Cochrane中央注册的对照试验,2015年4月ClinicalTrials.gov数据库搜索。迦得的所有随机对照试验(相关的)被认为是包括在这个荟萃分析。奎硫平广泛性焦虑症患者提供端点的所有相关的结果相关的严重焦虑,响应速度,缓解率、整体的停药率,或因不良事件包括停药率。报告版本合适的临床研究进行了探讨,和重要的数据提取。测量的有效性结果由mean-changed分数等级量表的焦虑,和响应速度。结果:共有2248个随机的参与者包括三个相关的。quetiapine-treated的汇集mean-changed分数组比安慰剂组和与选择性5 -羟色胺再摄取抑制剂(SSRIs)。不幸的是,响应和缓解率只有50和150毫克/天quetiapine-XR(延长释放)优于安慰剂。 Their response and remission rates were comparable to SSRIs. The rates of pooled overall discontinuation and discontinuation due to adverse events of quetiapine-XR were greater than placebo. Only the overall discontinuation rate of quetiapine-XR at 50 and 150 mg/day and the discontinuation rate due to adverse events of quetiapine-XR at 50 mg/day were comparable to SSRIs. CONCLUSION: Based on this meta-analysis, quetiapine-XR is efficacious in the treatment of GAD in adult patients. Despite its low acceptability and tolerability, the use of 50-150 mg/day quetiapine-XR for adult GAD patients may be considered as an alternative treatment. Further well-defined studies should be conducted to warrant these outcomes.

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药物

喹硫平