喹硫平治疗帕金森病的精神病。

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Shotbolt P,撒母耳,大卫

喹硫平治疗帕金森病的精神病。

其他副词神经Disord。2010年11月,3 (6):339 - 50。doi: 10.1177 / 1756285610389656。

PubMed ID

21179595 (在PubMed

]

文摘

精神病(妄想和幻觉)是一种常见的帕金森病(PD)的nonmotor特性。使用旧的典型抗精神病药物导致运动症状恶化。非典型性抗精神病药物的介绍了一系列的治疗选择。这些药物包括氯氮平、利培酮、奥氮平、阿立哌唑和喹硫平。都有被用来治疗精神病PD有不同的成功。氯氮平与证明是唯一的药物功效。我们复习喹硫平的疗效的证据。八项研究评估喹硫平在191名患者中使用,以改善精神病记录152年(80%)。除了开放性研究,有两单盲随机试验比较喹硫平与氯氮平。这些研究表明,喹硫平氯氮平在控制精神病也有类似的功效。 Following the promising results of the open-label and clozapine comparison studies, five randomized, controlled trials (RCTs) have been performed to further establish the efficacy of quetiapine. Unfortunately, the results have been disappointing. The only positive placebo-controlled study excluded patients with delusions, which seem to be harder to treat than hallucinations. The four negative RCTs discussed seriously undermine the evidence from the open-label studies. The differences in design and interpretation of the RCTs emphasizes the need for further large, well-controlled trials, using strict inclusion criteria, appropriate psychosis rating scales, carer input and clinical significance. Currently, many physicians continue to cautiously offer a trial of low-dose quetiapine empirically. Clozapine should be considered in patients who can tolerate the required blood monitoring.

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药物

喹硫平