喹硫平的多个剂量药物动力学和它的一些代谢产物在中国患有精神分裂症。

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肯塔基州李,李X,陈锌、彭,李张BK,高清

喹硫平的多个剂量药物动力学和它的一些代谢产物在中国患有精神分裂症。

学报杂志。2004年3月,25 (3):390 - 4。

PubMed ID

15000896 (在PubMed

]

文摘

目的:研究喹硫平的多个剂量药物动力学及其亚砜-糠酸,7-hydroxy-N-dealkyl-metabolites中国患有精神分裂症。方法:21例(11女性和10个男性)有喹硫平每天两次来控制症状。剂量达到200毫克每日两次后,血液采样研究药物动力学。喹硫平的血浆浓度及其代谢物被HPLC-MS化验。结果:喹硫平的主要药代动力学参数,7-hydroxy-N-dealkyl-quetiapine,喹硫平亚砜,7-hydroxy-quetiapine如下:最高温度分别为2.0(0.3 - -5.0),4.0(1.5 - -6.0),3.0(0.5 - -5.0),和3.0 (0.5 - -5.0)h分别;t1/2(7 + / 3),(9.4 + / - -2.7),(7 + / 3),和(8 + / 5)h,分别;Cmax (SS)(678 + / -325),(19 + / 5)(451 + / -216),和(58 + / -22)microg / L,分别;Cmin (SS)(51 + / -68)(3.3 + / - -1.6),(35 + / -36),和(5 + / 4)microg / L,分别;骑兵(SS)(295 + / -144),(13 + / 4)(209 + / -71),和(28 + / 9)微/ L,分别;AUC(经历)(SS)(3538 + / - 1 728),(153 + / -44),(2512 + / -854)和(335 + / -104)microg.h.L(1),分别; AUC(0-infinite)(SS) were (5,534+/-4 198), (287+/-107), (3,858+/-2 012), and (529+/-262) microg.h.L(-1), respectively; Ke were (0.11+/-0.03), (0.079+/-0.019), (0.11+/-0.03), and (0.103+/-0.028) h(-1), respectively; CL/F and V/F of quetiapine were (67+/-25) L.h(-1) and (672+/-394) L, respectively. The plasma concentrations for the four compounds reached a steady state within 48 h at the dose of 200 mg initiation. These parameters were not statistically different between genders. CONCLUSIONS: Quetiapine was absorbed quickly, distributed widely, and metabolized mainly to be quetiapine sulfoxide. The elimination speeds of quetiapine and its three metabolites were similar. Gender had no effect on the pharmacokinetics of quetiapine and its metabolites. The clinical dosage regime caused no drug accumulation.

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药物

喹硫平