常见血清肌酸磷酸激酶和乳酸脱氢酶增加在地奥司明疗法:两个案例报告。
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米兰G,里昂,Fucile C, Zuccoli ML, Stimamiglio,马特利,Mattioli F
常见血清肌酸磷酸激酶和乳酸脱氢酶增加在地奥司明疗法:两个案例报告。
J地中海众议员2014年6月16日,8:194。doi: 10.1186 / 1752-1947-8-194。
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24934505 (在PubMed]
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简介:短期地奥司明管理通常被认为是安全的,只有轻微副作用(胃和腹痛、腹泻、皮肤疾病,和头痛)偶尔观察到。在四年时间内,全科医生注意到17例轻度,diosmin-induced副作用,其中两个显示特别感兴趣。案例介绍:案例1:一位55岁的白人妇女患有慢性腿部静脉功能不全。医生给她开了地奥司明450毫克,一天两次。经过5天的治疗,她腿痛(肌痛),和地奥司明疗法被停职。她自发的尝试毒品重新和她的腿疼痛再次出现。因此,她接受了血液分析显示,肌酸磷酸激酶水平的高度。肌酸磷酸激酶值归一化只有经过长时间的停药的治疗。案例2:一个79岁的白人男子被诊断出患有急性痔的综合征。经过21天的连续地奥司明治疗,检测到了血清乳酸脱氢酶含量增加。 In both cases a comprehensive analysis of all possible causes for enzyme elevation was made. CONCLUSIONS: A feasible hypothesis to explain these rare effects could be that exaggerated adrenergic activity occurred on microcirculation, leading to an excessive peripheral vasoconstriction and subsequent ischemic damage. An individual predisposition is strongly suggested. A concurrence of events was probably responsible for the elevation of nonspecific tissue necrosis markers. Physicians and patients must be aware of these rare, but possible, adverse drug reactions.
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