时间序列建模的海洛因、吗啡药物作用。

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Tschacher W, Haemmig R, Jacobshagen N

时间序列建模的海洛因、吗啡药物作用。

精神药理学(Berl)。2003年1月,165 (2):188 - 93。Epub 2002年10月29日。

PubMed ID

12404073 (在PubMed

]

文摘

原理:临床观察和最近的发现建议接受不同的吗啡和海洛因静脉注射吸毒者在鸦片维护项目。我们推测,这是由于这些药物的感知影响的差异,尤其是如何期望和副作用的药物相互作用。目标:我们测量所需的和负面影响的患者注射大剂量的吗啡和海洛因来确定因果之间的相互作用这两种类型的效果和测试微分作用机理的假说。方法:33例(5个女性,28岁男性;平均持续时间前街海洛因使用10.7年,平均年龄30.1岁)被随机双盲的物质分配组。每个参与者的平均日剂量的海洛因条件(n = 17)是491毫克,吗啡的条件(n = 16) 597毫克。观察期间持续了3周;平均70注射。每次注射的药物后,药物效果记录系统的各个方面。评级的因素概括为“兴奋”和“负面影响”。 Time series models were computed for each participant on the basis of the factor scores, using vector autoregression (VAR). RESULTS: A highly significant difference between the substances was found in the interaction between "euphoria" and "adverse effects". Adverse effects of heroin preceded higher euphoria, whereas adverse effects of morphine preceded subsequent lower euphoria. Additionally, the finding of a higher level of adverse effects in morphine was replicated. CONCLUSIONS: Results point to different mechanisms of action of the two opioids when the perceived drug effects are evaluated in a field setting. This may explain the better acceptance of heroin in opiate-assisted treatment of intravenous drug patients. The method used can be a valuable tool for the comparison of substance groups other than opioids.

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药物

二乙酰吗啡