脱氢表雄酮对肌肉力量的影响,老年人的身体功能:系统回顾。

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贝克西城,卡兰,肯尼

脱氢表雄酮对肌肉力量的影响,老年人的身体功能:系统回顾。

J Geriatr Soc。2011年6月,59岁(6):997 - 1002。doi: 10.1111 / j.1532-5415.2011.03410.x。Epub 2011年6月7日。

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21649617 (在PubMed

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文摘

目的:评价研究评估的影响脱氢表雄酮(DHEA)补充在老年人身体成分和物理性能。设计:系统回顾从数据库搜索,识别出的医学文献引用列表,和最近的会议论文集的定性评估所需的端点。设置:不适用。参与者:50岁以上的成年人。口服补充脱氢表雄酮干预:有或没有伴随的运动。测量:肌肉力量、身体功能和物理性能。结果:155年合格的研究中,八个参与者(n = 661)符合入选标准。研究不同的包括人口、随访期间,干预措施(例如,运动)。七个研究检验措施的肌肉力量。一个研究表明改善握力,一个显示改善胸部按压,两个显示改善腿出版社,和一个显示改善膝盖扩展和弯曲。 Nevertheless, similar numbers of studies had negative results for each of these endpoints. Five studies examined measures of physical function and performance. Only one study showed improvement in a composite score measuring physical performance; the rest reported no differences between DHEA and control for any end point. CONCLUSION: Overall, the benefit of DHEA on muscle strength and physical function in older adults remains inconclusive. Some measures of muscle strength may improve, although consensus was not reached. DHEA does not appear to routinely benefit measures of physical function or performance. Further large clinical trials are necessary to better identify the clinical role of DHEA supplementation in this population.

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