内源性性激素和心血管疾病发病率在男性。
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阿勒夫J, Pencina MJ,阿明年代,南BH,本杰明EJ, Murabito JM,王TJ,克纳普PE、RB Sr,达哈年代,Vasan RS
内源性性激素和心血管疾病发病率在男性。
安实习生地中海。2006年8月1日,145 (3):176 - 84。
- PubMed ID
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16880459 (在PubMed]
- 文摘
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背景:数据表明内源性性激素(睾酮、硫酸脱氢表雄酮(硫酸脱氢表雄酮(dhea - s)和雌二醇)影响心血管疾病(CVD)的危险因素和血管功能。然而,前瞻性研究性激素有关心血管疾病发病率在男性产生了不一致的结果。目的:研究协会循环男性性激素水平与心血管疾病风险。设计:前瞻性队列研究。设置:在马萨诸塞州弗雷明汉以社区为基础的研究。参与者:2084中年白人男性没有心血管疾病的基线。测量:作者用多变量Cox回归与基线水平的睾丸素,硫酸脱氢表雄酮(dhea - s,雌二醇心血管疾病的发病率(冠状动脉、脑血管或周围性血管疾病或心力衰竭)在10年的随访。结果:随访期间,386人(18.5%)经历了第一次CVD事件。对基线标准心血管疾病风险因素调整后,高雌二醇水平降低心血管疾病的风险(风险比/ SD增加日志雌二醇,0.90(95%可信区间,0.82 - 0.99);P = 0.035)。 The authors observed effect modification by age: Higher estradiol levels were associated with lower CVD risk in older (median age >56 years) men (hazard ratio per SD increment, 0.86 [CI, 0.78 to 0.96]; P = 0.005) but not in younger (median age < or =56 years) men (hazard ratio per SD increment, 1.11 [CI, 0.89 to 1.38]; P = 0.36). The association of higher estradiol level with lower CVD incidence remained robust in time-dependent Cox models (updating standard CVD risk factors during follow-up). Serum testosterone and DHEA-S levels were not statistically significantly associated with incident CVD. LIMITATIONS: Sex hormone levels were measured only at baseline, and the findings may not be generalizable to women and nonwhite people. CONCLUSIONS: In the community-based sample, a higher serum estradiol level was associated with lower risk for CVD events in older men. The findings are consistent with the hypothesis that endogenous estrogen has vasculoprotective influences in men.
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