药物动力学的氯胺酮及其代谢物、norketamine丸的氯胺酮静注后,isoflurane-anesthetized狗。

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Pypendop BH, Ilkiw我

药物动力学的氯胺酮及其代谢物、norketamine丸的氯胺酮静注后,isoflurane-anesthetized狗。

J兽医研究》2005年12月,66 (12):2034 - 8。doi: 10.2460 / ajvr.2005.66.2034。

PubMed ID

16379643 (在PubMed

]

文摘

目的:确定氯胺酮的药物动力学和norketamine isoflurane-anesthetized狗。Animals-6狗。过程:异氟烷的最小肺泡浓度(MAC)决定在每一个狗。异氟烷浓度被设定在0.75倍个人的MAC和氯胺酮(3毫克/公斤)是管理IV。收集血液样本在不同时期后,克他命管理。血立刻离心机,和等离子体和冷冻,直到分开分析。氯胺酮和norketamine浓度测定血浆样品的液相色谱-光谱法的使用。氯胺酮浓度时间数据安装在舱模型。Norketamine浓度时间数据被使用noncompartmental检查分析。结果:异氟烷的MAC是1.43 + / - 0.18%(平均+ / - SD)。2-compartment模型最好描述克他命的性格。 The apparent volume of distribution of the central compartment, the apparent volume of distribution at steady state, and the clearance were 371.3 +/- 162 mL/kg, 4,060.3 +/- 2,405.7 mL/kg, and 58.2 +/- 17.3 mL/min/kg, respectively. Norketamine rapidly appeared in plasma following ketamine administration and had a terminal half-life of 63.6 +/- 23.9 minutes. A large variability in plasma concentrations, and therefore pharmacokinetic parameters, was observed among dogs for ketamine and norketamine. CONCLUSIONS AND CLINICAL RELEVANCE: In isofluraneanesthetized dogs, a high variability in the disposition of ketamine appears to exist among individuals. The disposition of ketamine may be difficult to predict in clinical patients.

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