Albumin-bound基础胰岛素类似物(地特胰岛素发生和NN344):类似的活动时间配置文件变化但低于2型糖尿病的胰岛素。
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克莱恩O, Lynge J是Endahl L, Damholt B, Nosek L, Heise T
Albumin-bound基础胰岛素类似物(地特胰岛素发生和NN344):类似的活动时间配置文件变化但低于2型糖尿病的胰岛素。
糖尿病ob金属底座。2007;9 (3):290 - 9。
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17391154 (在PubMed]
- 文摘
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目的:本研究比较了活动时间的小说albumin-bound基础胰岛素类似物NN344与地特胰岛素发生,在2型糖尿病患者胰岛素。方法:27来男性2型糖尿病患者(体重指数30.8 + / - 2.6公斤/米(2)(+ / -其中的意思。)、血红蛋白(1 c) 7.6 + / - 1.1%)加入这个随机、双盲试验和参与六euglycaemic葡萄糖钳实验(目标血糖(BG) 5更易/ l)。在三个实验参与者收到NN344剂量的0.8,1.6和2.8计量单位(DU) (1 DU对应6 nmol NN344)每公斤体重。在其他三个实验中,参与者收到了0.4、0.8和1.4 U /公斤地特胰岛素发生或胰岛素。胰岛素制剂的特点对于其对葡萄糖输注率的影响(女孩)(在特定时间的行动和受试)和主客体之间的可变性,BG、c -肽、游离脂肪酸(FFA)、内源性葡萄糖生产(出路和外围葡萄糖吸收(PGU) 24 h post-dose。结果:平均GIR概要文件为所有三个准备形似/平整度和显示增加效应(GIR曲线下的面积:AUC-GIR(总))与增加剂量(低剂量:647 + / - 580,882 + / - 634,571 + / - 647毫克/公斤(地特胰岛素发生与NN344与胰岛素];中等剂量:1203 + / - 816,1720 + / - 1109,1393 + / - 1203毫克/公斤,高剂量:2171 + / - 1344,3119 + / - 1549,2952 + / - 2028毫克/公斤;p = 0.48)。行动的持续时间增加而增加剂量的胰岛素制剂,没有重大区别治疗。BG仍低于7更易/ l几乎所有的实验。 Within-subject variability was lower for the albumin-bound insulin analogues, insulin detemir and NN344, than for insulin glargine (p < 0.0001). Between-subject variability did not differ between treatments, nor did the effects on BG, C-peptide, FFA, EGP or PGU. CONCLUSIONS: In individuals with type 2 diabetes, the time-action profiles and the duration of action of the albumin-bound insulin analogues, insulin detemir and NN344, were comparable with those of insulin glargine, whereas within-subject variability in the metabolic effect was significantly lower. Therefore, insulin detemir and NN344 seem to be as well suited as insulin glargine for once-daily administration in type 2 diabetes. The better predictability may be an important characteristic of the albumin-bound analogues as insulin detemir has already been shown to improve hypoglycaemia.