短期跟踪操作和不运转的人类颈动脉的动脉粥样硬化高分辨率磁共振成像。

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布朗菲尔德马丁•K D, Karmonik C,桑福德L,托雷斯L, Insull W, Morrisett J

短期跟踪操作和不运转的人类颈动脉的动脉粥样硬化高分辨率磁共振成像。

2007年世界J Surg. 4月;31 (4):723 - 32。

PubMed ID

17354027 (在PubMed

]

文摘

简介:一项研究表明磷脂(PL)的疗效与蛋白质(apoAI米兰)导致4.6%回归的动脉粥样化体积评估血管内超声(治疗作用在一组颈动脉粥样硬化患者47。这项研究的结果提出的问题仅磷脂是否能产生类似的效果。方法:回答这个问题39受试者的试验五个网站设计。狭窄> 15%的患者至少有一个颈动脉由我们接受静脉注射PL(200毫克/公斤)或安慰剂注入每周8周。墙/外墙比率,lipid-rich百分比/坏死核心,和钙化百分比比例测量血管壁的磁共振成像(MRI)在0、4、8、14周。结果:其中7名患者评估的substudy我们网站允许比较五个维度的unoperated-unoperated颈双和两个operated-unoperated双。在病人1,核磁共振测量不运转的左,不运转的右颈动脉跟踪尽早研究几乎相同。两个颈动脉显示类似数量的增加总墙(+ 61%比56%),正常的墙(+ 51%比49%),和斑块(+ 99%比85%)。颈动脉显示类似的内腔体积减少(-11%比-17%)。其他四个unoperated-unoperated颈双显示尺寸变化在14周病人1的类似。 In patient 2, who underwent left endarterectomy, the operated carotid had a total artery volume of 2300 mm(3), about twofold greater than the unoperated carotid (1100 mm(3)). Operated and unoperated carotid measurements tracked in parallel. The unoperated carotid had volume increases of 25% (+200 mm(3)) in total wall, +19% (+100 mm(3)) in normal wall, and 43% (+75 mm(3)) in plaque. The operated carotid lumen showed no significant changes. Patient 7, who also underwent left endarterectomy, exhibited carotid changes similar to those of patient 2. CONCLUSIONS: Individual unoperated carotid pairs have volumes that track almost identically. In unilateral operated carotid pairs, the operated artery has 1.5- to 2.0-fold greater volume than unoperated carotids. In each of our two unilaterally operated patients, the operated carotid had decreased plaque volume (-3%, -58%), whereas the unoperated carotid had increased plaque volume (+43%, +7%). Among the five unoperated patients, one pair had 85%/99% increase in plaque volume; one pair had -15%/-10% decrease; and the other three pairs had intermediate changes. This study provides additional support to the view that unoperated human carotid arteries are bilaterally symmetrical.

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