震颤的治疗。
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施耐德SA Deuschl G
震颤的治疗。
神经病治疗。2014年1月,11 (1):128 - 38。doi: 10.1007 / s13311 - 013 - 0230 - 5。
- PubMed ID
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24142589 (在PubMed]
- 文摘
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地震是一种运动过度的运动障碍,其特征是节奏振荡的一个或多个身体部位。它可以被禁用,可能影响生活质量。各种病因亚型的地震识别,特发性震颤(ET)和帕金森震颤是最常见的。这里我们回顾当前文献关于ET和头部震颤治疗和语音震颤,以及矛盾的震颤、直立性震颤、地震由于多发性硬化症(MS)或脑干和丘脑病变,神经性震颤、和功能(心因性)震颤,总结主要发现。大多数研究可供等,只有少数研究特别关注其他地震形式。对照试验外等是罕见的,因此大部分的建议是基于一个低水平的证据。等、普萘洛尔和普里米酮被认为是首选的药物平均效应值减少大约50%的震颤。托吡酯的疗效还支持通过大型双盲安慰剂对照试验,而其他药物没有支持的证据。平均效应值约90%的脑深部电刺激在细胞核ventralbeplayappis中间部或丘脑核可能是最有效的治疗;然而,没有对照试验是用于严重影响病人。 Dystonic limb tremor may respond to anticholinergics. Botulinum toxin improves head and voice tremor. Gabapentin and clonazepam are often recommended for orthostatic tremor. MS tremor responds only poorly to drug treatment. For patients with severe MS tremor, thalamic deep brain stimulation has been recommended. Patients with functional tremor may benefit from antidepressants and are best be treated in a multidisciplinary setting. Several tremor syndromes can already be treated with success. But new drugs specifically designed for tremor treatment are needed. ET is most likely covering different entities and their delineation may also improve treatment. Modern study designs and long-term studies are needed.
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