隔日给药的功效和每日剂量阿托伐他汀。

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贾法里,Ebrahimi R, Ahmadi-Kashani M,巴里H,巴希尔M

隔日给药的功效和每日剂量阿托伐他汀。

J Cardiovasc杂志。2003年6月,8 (2):123 - 6。

PubMed ID

12808485 (在PubMed

]

文摘

背景:阿托伐他汀的合成抑制剂3-hydroxy-3-methylglutaryl辅酶a还原酶(β)。在安慰剂对照试验,它已被证明显著降低低密度脂蛋白胆固醇摄入量有关,总胆固醇和甘油三酯。这个试验的疗效相比阿托伐他汀日常行政与隔日给药。方法:这是一个随机、前瞻性、nonblinded对照临床试验。54个患者低密度脂蛋白胆固醇的100 - 200 mg / dL被录取。基线空腹血脂(总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和甘油三酯),肝功能测试(天冬氨酸氨基转移酶和丙氨酸转氨酶)和肌酸激酶。病人被随机分为三个剂量阿托伐他汀组。每天我收到10毫克的阿托伐他汀组,第二组收到10毫克每隔一天,第三组接受20毫克每隔一天。与阿托伐他汀治疗6周后,空腹血脂,肝功能测试,肌酸激酶浓度被重绘。治疗依从性评估在每个访问。 RESULTS: Of the 54 patients enrolled, 46 completed the study. All three regimens significantly reduced total cholesterol and low-density lipoprotein cholesterol compared to baseline. No statistically significant differences existed between the three groups in regards to total, or a percentage, decrease in total cholesterol and low-density lipoprotein cholesterol at 6 weeks compared to baseline. All regimens were well tolerated and none of the patients had a significant elevation of liver enzymes or creatine kinase during the course of the study. CONCLUSION: Alternate-day dosing of atorvastatin is an efficacious and safe alternative to daily dosing.

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药物靶点

药物	目标	类	生物	药理作用	行动
阿托伐他汀	3-hydroxy-3-methylglutaryl-coenzyme一个还原酶	蛋白质	人类	是的	抑制剂	细节