前瞻性研究膳食脂肪和年龄相关性黄斑变性的风险。

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曹E,挂着年代,威利•WC, Spiegelman D, Rimm EB, Seddon JM,科迪兹GA, Hankinson SE

前瞻性研究膳食脂肪和年龄相关性黄斑变性的风险。

是中国减轻。2001年2月,73 (2):209 - 18。

PubMed ID

11157315 (在PubMed

]

文摘

背景:总脂肪摄入量之间的关系和特定类型的脂肪和年龄相关性黄斑变性(AMD)仍不清楚。目的:我们的目的是检查前瞻性脂肪摄入量之间的关系和AMD。设计:我们进行了一项前瞻性随访研究参与者的护士健康研究和健康专业随访研究。在基线(1984对女性和1986名男性),这项研究包括42743名女性和29746名男性>或y = 50岁没有AMD的诊断之后,直到1996年。脂肪摄入食物频率问卷评估。结果:我们应计567 AMD患者视力丧失的20/30或更糟。多元相对危险度(RR)的最高与最低者总脂肪摄入量为1.54(95%置信区间CI: 1.17, 2.01;趋势P = 0.008)。亚麻酸与AMD的风险呈正相关(顶部和底部的纤维RR: 1.49;95%置信区间:1.15,1.94; P for trend = 0.0009). Docosahexaenoic acid had a modest inverse relation with AMD (top versus bottom quintile of RR: 0.70; 95% CI: 0.52, 0.93; P for trend = 0.05), and >4 servings of fish/wk was associated with a 35% lower risk of AMD compared with < or = 3 servings/mo (RR: 0.65; 95% CI: 0.46, 0.91; P for trend = 0.009). CONCLUSIONS: Total fat intake was positively associated with risk of AMD, which may have been due to intakes of individual fatty acids, such as linolenic acid, rather than to total fat intakes per se. A high intake of fish may reduce the risk of AMD.

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药物

亚麻酸