Altretamine是一种有效的姑息治疗复发性卵巢上皮癌患者。

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马利克IA

Altretamine是一种有效的姑息治疗复发性卵巢上皮癌患者。

日本J肿瘤防治杂志。2001;2月31 (2):69 - 73。

PubMed ID

11302345 (在PubMed

]

文摘

背景:复发性卵巢上皮癌患者的管理是很困难的。虽然有几个代理活跃,反应是短暂的,只有少数的病人中观察到。这些药物的副作用是实质性的。需要更有效和更少的有毒的疗法。Altretamine是耐受性良好口服剂以最小的毒性。只有少数试验评估其疗效在复发性卵巢上皮癌的一个代理。方法:前瞻性研究复发性卵巢上皮癌患者能够采取口服药物和有足够的骨髓,肝脏和肾脏功能。所有先前接受至少一个以铂为基础的化疗方案和复发或未能达到一个适当的反应。结果:17例进行了研究。最常见的组织学亚型浆液腺癌。 Seven patients had platinum refractory disease. The mean duration of therapy was 6.1 months. Six patients (35%) achieved complete or partial remission, time to progression was 6.0 months and mean overall survival was 15.1 months. Toxicity was primarily nausea, vomiting and asthenia and was easily manageable. CONCLUSION: Altretamine is an acceptable and apparently less toxic alternative to other cytotoxic drugs used for palliation of patients with recurrent epithelial ovarian cancer.

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药物

Altretamine