协会的血清雌激素酮水平与日本女性在绝经后雌激素受体阳性乳腺癌的风险。

文章的细节

引用

复制到剪贴板

三好Y, Y痰迹,田口T,玉城丹尼Y,野口勇

协会的血清雌激素酮水平与日本女性在绝经后雌激素受体阳性乳腺癌的风险。

癌症研究杂志2003年6月,9(6):2229 - 33所示。

PubMed ID

12796390 (在PubMed

]

文摘

目的:一些报告展示了高血清雌激素水平之间的关系,在绝经后妇女患乳腺癌的风险。假设乳腺癌发生在绝经后妇女血清雌激素水平高的更可能是雌激素受体(ER)阳性。因此,我们调查是否高血清雌激素酮(E(1)水平与绝经后妇女雌激素受体阳性乳腺癌风险有关。实验设计:一项病例对照研究对71例绝经后乳腺癌患者和73名对照(绝经后健康女性)。血清E(1)水平研究协会与乳腺癌的风险调整后的各种流行病学危险因素。此外,乳腺癌的临床病理的特点引起的高水平的E (1)。结果:女性的高tertile E(1)水平显著(P < 0.01),增加乳腺癌的风险比女性低tertile(比值比(或),4.14;95%可信区间(CI), 1.44 - -11.87)。子集分析根据ER状况表明,妇女的高tertile E(1)水平有一个明显的风险增加雌激素受体阳性乳腺癌(OR, 23.79;95%置信区间,3.50 - -161.59),但不是为er阴性乳腺癌(OR, 1.45; 95% CI, 0.41-5.15) as compared with women in the low tertile. Tumor size and lymph node status were not significantly different between women in the high tertile and those in the intermediate and low tertiles. But the frequency of low-histological-grade tumors and ER-positive tumors (88 and 67%, respectively) showed a greater trend toward an increase (P = 0.06 and P = 0.07, respectively) in women in the high tertile than those (69 and 46%, respectively) in the intermediate and low tertiles. In addition, ER levels in ER-positive tumors were significantly (P < 0.05) higher in women in the high tertile (245.3 +/- 37.1 fmol/mg protein) than those in the intermediate and low tertiles (134.0 +/- 31.3 fmol/mg protein). CONCLUSIONS: Postmenopausal women with high serum E(1) levels have a significantly increased risk for ER-positive, but not ER-negative, breast cancer. Breast cancers arising in women with high E(1) levels show a high ER positivity as well as high ER content. Measurement of serum E(1) levels would be clinically useful in the selection of postmenopausal women who can benefit from prophylactic use of tamoxifen because tamoxifen can prevent ER-positive, but not ER-negative, breast cancer.

beplay体育安全吗DrugBank数据引用了这篇文章

药物

雌激素酮