NAV

Propanidid

This drug entry is astuband has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Propanidid
DrugBank Accession Number
DB13234
Background

An intravenous anesthetic that has been used for rapid induction of anesthesia and for maintenance of anesthesia of short duration. (From Martindale, The Extra Pharmacopoeia, 30th ed, p918)

Type
Small Molecule
Groups
Experimental
Structure
 3D
Similar Structures
Weight
Average: 337.416
Monoisotopic: 337.188922973
Chemical Formula
C18H27NO5
Synonyms
  • Propanidid
  • Propanidido
  • Propanididum
External IDs
  • BAYER 1420
  • BAYER-1420
  • FBA 1420
  • FBA-1420
  • TH-2180
  • WH 5668
  • WH-5668

Pharmacology

Indication

Not Available

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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRsBrowse all" title="" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">
Not Available

Interactions

Drug InteractionsLearn More" title="" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction
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interactions in your software
1,2-Benzodiazepine The risk or severity of adverse effects can be increased when 1,2-Benzodiazepine is combined with Propanidid.
Acetazolamide The risk or severity of adverse effects can be increased when Acetazolamide is combined with Propanidid.
Acetophenazine The risk or severity of adverse effects can be increased when Acetophenazine is combined with Propanidid.
Agomelatine The risk or severity of adverse effects can be increased when Agomelatine is combined with Propanidid.
Alfentanil The risk or severity of adverse effects can be increased when Alfentanil is combined with Propanidid.
Alimemazine The risk or severity of adverse effects can be increased when Alimemazine is combined with Propanidid.
Almotriptan The risk or severity of adverse effects can be increased when Almotriptan is combined with Propanidid.
Alosetron The risk or severity of adverse effects can be increased when Alosetron is combined with Propanidid.
Alprazolam The risk or severity of adverse effects can be increased when Alprazolam is combined with Propanidid.
Alverine The risk or severity of adverse effects can be increased when Alverine is combined with Propanidid.
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Food Interactions
Not Available

Products

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International/Other Brands
Epontol

Categories

ATC Codes
N01AX04 — Propanidid
Drug Categories
Chemical TaxonomyProvided byClassyfire
Description
This compound belongs to the class of organic compounds known as anisoles. These are organic compounds containing a methoxybenzene or a derivative thereof.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Phenol ethers
Sub Class
Anisoles
Direct Parent
Anisoles
Alternative Parents
Phenoxy compounds/Methoxybenzenes/Alkyl aryl ethers/Tertiary carboxylic acid amides/Carboxylic acid esters/Monocarboxylic acids and derivatives/Organopnictogen compounds/Organonitrogen compounds/Organic oxides/Hydrocarbon derivatives
show 1 more
Substituents
Alkyl aryl ether/Anisole/Aromatic homomonocyclic compound/Carbonyl group/Carboxamide group/Carboxylic acid derivative/Carboxylic acid ester/Ether/Hydrocarbon derivative/Methoxybenzene
show 10 more
Molecular Framework
Aromatic homomonocyclic compounds
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
AO82L471NS
CAS number
1421-14-3
InChI Key
KEJXLQUPYHWCNM-UHFFFAOYSA-N
InChI
InChI=1S/C18H27NO5/c1-5-10-23-18(21)12-14-8-9-15(16(11-14)22-4)24-13-17(20)19(6-2)7-3/h8-9,11H,5-7,10,12-13H2,1-4H3
IUPAC Name
propyl 2-{4-[(diethylcarbamoyl)methoxy]-3-methoxyphenyl}acetate
SMILES
CCCOC(=O)CC1=CC(OC)=C(OCC(=O)N(CC)CC)C=C1

References

一般引用
Not Available
ChemSpider
14283
RxNav
8758
ChEBI
135432
ChEMBL
CHEMBL2105345
ZINC
ZINC000002039588
Wikipedia
Propanidid

Clinical Trials

Clinical TrialsLearn More" title="" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">
Phase Status Purpose Conditions Count

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
Property Value Source
Water Solubility 0.229 mg/mL ALOGPS
logP 2.8 ALOGPS
logP 2.15 Chemaxon
logS -3.2 ALOGPS
pKa (Strongest Acidic) 16.59 Chemaxon
pKa (Strongest Basic) -4.6 Chemaxon
Physiological Charge 0 Chemaxon
Hydrogen Acceptor Count 4 Chemaxon
Hydrogen Donor Count 0 Chemaxon
Polar Surface Area 65.07 Å2 Chemaxon
Rotatable Bond Count 11 Chemaxon
Refractivity 91.53 m3·mol-1 Chemaxon
Polarizability 37.52 Å3 Chemaxon
Number of Rings 1 Chemaxon
Bioavailability 1 Chemaxon
Rule of Five Yes Chemaxon
Ghose Filter Yes Chemaxon
Veber's Rule No Chemaxon
MDDR-like规则 No Chemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Spectrum Spectrum Type Splash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS Not Available

Drug created at June 23, 2017 20:38 / Updated at February 21, 2021 18:54