Glycylpeptide N-tetradecanoyltransferase 2

Details

Name
Glycylpeptide N-tetradecanoyltransferase 2
Synonyms
  • 2.3.1.97
  • Myristoyl-CoA:protein N-myristoyltransferase 2
  • NMT 2
  • Peptide N-myristoyltransferase 2
  • Type II N-myristoyltransferase
Gene Name
NMT2
Organism
Humans
Amino acid sequence
>lcl|BSEQ0012639|Glycylpeptide N-tetradecanoyltransferase 2 MAEDSESAASQQSLELDDQDTCGIDGDNEEETEHAKGSPGGYLGAKKKKKKQKRKKEKPN SGGTKSDSASDSQEIKIQQPSKNPSVPMQKLQDIQRAMELLSACQGPARNIDEAAKHRYQ FWDTQPVPKLDEVITSHGAIEPDKDNVRQEPYSLPQGFMWDTLDLSDAEVLKELYTLLNE NYVEDDDNMFRFDYSPEFLLWALRPPGWLLQWHCGVRVSSNKKLVGFISAIPANIRIYDS VKKMVEINFLCVHKKLRSKRVAPVLIREITRRVNLEGIFQAVYTAGVVLPKPIATCRYWH RSLNPRKLVEVKFSHLSRNMTLQRTMKLYRLPDVTKTSGLRPMEPKDIKSVRELINTYLK QFHLAPVMDEEEVAHWFLPREHIIDTFVVESPNGKLTDFLSFYTLPSTVMHHPAHKSLKA AYSFYNIHTETPLLDLMSDALILAKSKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYL YNWRCPGTDSEKVGLVLQ
Number of residues
498
分子量
56979.755
Theoretical pI
7.65
GO Classification
Functions
glycylpeptide N-tetradecanoyltransferase activity
Processes
intracellular transport of virus/N-terminal peptidyl-glycine N-myristoylation/phototransduction, visible light/regulation of rhodopsin mediated signaling pathway/rhodopsin mediated signaling pathway/viral process/viral protein processing/virion assembly
Components
cytoplasm/cytosol/extrinsic component of membrane/Golgi apparatus/plasma membrane
General Function
Glycylpeptide n-tetradecanoyltransferase activity
Specific Function
Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0012640|Glycylpeptide N-tetradecanoyltransferase 2 (NMT2) ATGAGGAGGAGACGGAGCACGCCAAAGGAAGTCCTGGAGGGTATTTGGGAGCCAAAAAGA AAAAGAAGAAACAGAAGAGAAAAAAGGAGAAACCAAATTCCGGAGGCACCAAGTCAGACT CGGCATCTGATTCCCAGGAGATTAAAATTCAGCAGCCTTCGAAACACAACACCATCTGGC AGCAGATTTCAGCGGGAGCAGCCATGGAATCCCAGTGTTCCAATGCAGAAGTTGCAGGAT ATCCAGAGAGCAATGGAGCTGCTATCCGCATGCCAGGGCCCAGCCAGGAACATTGATGAG GCTGCAAAGCACAGATACCAGTTTTGGGACACACAACCGGTACCAAAACTAGATGAAGTC ATAACATCTCATGGTGCAATTGAACCAGATAAAGACAACGTACGCCAAGAACCGTATTCT TTGCCACAGGGTTTTATGTGGGACACTTTAGACTTGAGTGATGCCGAAGTGCTCAAGGAG TTATACACGTTGTTAAATGAGAATTACGTAGAAGATGATGACAATATGTTCCGATTTGAC TATTCACCCGAGTTCCTGTTGTGGGCTCTGCGTCCACCAGGCTGGCTCCTGCAGTGGCAC TGTGGGGTCAGAGTGTCTTCAAATAAAAAACTGGTCGGGTTCATAAGTGCCATCCCAGCA AACATTCGGATTTATGACAGTGTGAAGAAGATGGTAGAAATCAACTTTCTTTGTGTTCAT AAGAAGTTGAGATCGAAACGGGTAGCCCCAGTGCTAATCCGAGAGATCACTAGAAGAGTG AACCTGGAAGGGATCTTCCAGGCTGTGTACACCGCGGGAGTGGTTCTTCCTAAGCCCATA GCCACATGCAGATACTGGCATCGATCACTAAACCCCAGAAAATTGGTAGAAGTGAAATTT TCTCACTTGAGTAGAAATATGACTTTACAGAGAACAATGAAGCTATACAGACTTCCAGAT GTTACAAAGACTTCAGGTTTGAGACCAATGGAACCAAAAGATATCAAATCAGTTCGAGAA TTAATCAACACTTACCTGAAGCAGTTTCATCTGGCTCCAGTGATGGATGAAGAGGAAGTA GCCCACTGGTTCCTCCCCCGGGAGCACATTATTGACACGTTTGTAGTGGAGAGCCCCAAC GGTAAACTGACTGATTTCCTGAGCTTCTATACGCTCCCCTCCACGGTGATGCACCACCCT GCTCACAAGAGCCTCAAAGCCGCCTACTCATTCTACAACATCCACACAGAGACGCCCCTG CTGGACCTCATGAGCGACGCGCTCATCCTGGCTAAATCGAAAGGATTTGATGTATTCAAT GCACTGGATTTGATGGAAAATAAGACATTCTTGGAAAAACTCAAGTTTGGTATAGGAGAT GGCAATTTGCAGTATTACCTGTACAATTGGAGGTGTCCAGGTACAGATTCTGAAAAGGTT GGACTAGTACTACAATAG
Chromosome Location
10
Locus
10p13
External Identifiers
Resource Link
UniProtKB ID O60551
UniProtKB Entry Name NMT2_HUMAN
GenBank Protein ID 3005065
GenBank Gene ID AF043325
HGNC ID HGNC:7858
General References
  1. Giang DK, Cravatt BF: A second mammalian N-myristoyltransferase. J Biol Chem. 1998 Mar 20;273(12):6595-8. [Article]
  2. Deloukas P, Earthrowl ME, Grafham DV, Rubenfield M, French L, Steward CA, Sims SK, Jones MC, Searle S, Scott C, Howe K, Hunt SE, Andrews TD, Gilbert JG, Swarbreck D, Ashurst JL, Taylor A, Battles J, Bird CP, Ainscough R, Almeida JP, Ashwell RI, Ambrose KD, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Bates K, Beasley H, Bray-Allen S, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Cahill P, Camire D, Carter NP, Chapman JC, Clark SY, Clarke G, Clee CM, Clegg S, Corby N, Coulson A, Dhami P, Dutta I, Dunn M, Faulkner L, Frankish A, Frankland JA, Garner P, Garnett J, Gribble S, Griffiths C, Grocock R, Gustafson E, Hammond S, Harley JL, Hart E, Heath PD, Ho TP, Hopkins B, Horne J, Howden PJ, Huckle E, Hynds C, Johnson C, Johnson D, Kana A, Kay M, Kimberley AM, Kershaw JK, Kokkinaki M, Laird GK, Lawlor S, Lee HM, Leongamornlert DA, Laird G, Lloyd C, Lloyd DM, Loveland J, Lovell J, McLaren S, McLay KE, McMurray A, Mashreghi-Mohammadi M, Matthews L, Milne S, Nickerson T, Nguyen M, Overton-Larty E, Palmer SA, Pearce AV, Peck AI, Pelan S, Phillimore B, Porter K, Rice CM, Rogosin A, Ross MT, Sarafidou T, Sehra HK, Shownkeen R, Skuce CD, Smith M, Standring L, Sycamore N, Tester J, Thorpe A, Torcasso W, Tracey A, Tromans A, Tsolas J, Wall M, Walsh J, Wang H, Weinstock K, West AP, Willey DL, Whitehead SL, Wilming L, Wray PW, Young L, Chen Y, Lovering RC, Moschonas NK, Siebert R, Fechtel K, Bentley D, Durbin R, Hubbard T, Doucette-Stamm L, Beck S, Smith DR, Rogers J: The DNA sequence and comparative analysis of human chromosome 10. Nature. 2004 May 27;429(6990):375-81. [Article]
  3. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  4. Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17. [Article]
  5. Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [Article]
  6. Thinon E, Serwa RA, Broncel M, Brannigan JA, Brassat U, Wright MH, Heal WP, Wilkinson AJ, Mann DJ, Tate EW: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells. Nat Commun. 2014 Sep 26;5:4919. doi: 10.1038/ncomms5919. [Article]

Drug Relations

Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details
DB02180 Myristoyl-Coa experimental unknown Details
DB02271 S-(2-oxo)pentadecylcoa experimental unknown Details
DB07061 1-(CYCLOHEXYLAMINO)-3-(6-METHYL-3,4-DIHYDRO-1H-CARBAZOL-9(2H)-YL)PROPAN-2-OL experimental unknown Details
DB07838 (Z)-3-BENZYL-5-(2-HYDROXY-3-NITROBENZYLIDENE)-2-THIOXOTHIAZOLIDIN-4-ONE experimental unknown Details