An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

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Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22.

PubMed ID

24275569 [View in PubMed

]

Abstract

Protein phosphorylation is one of the most common post-translational modifications. It plays key roles in regulating diverse biological processes of liver tissues. To better understand the role of protein phosphorylation in liver functions, it is essential to perform in-depth phosphoproteome analysis of human liver. Here, an enzyme assisted reversed-phase-reversed-phase liquid chromatography (RP-RPLC) approach with both RPLC separations operated with optimized acidic mobile phase was developed. High orthogonal separation was achieved by trypsin digestion of the Glu-C generated peptides in the fractions collected from the first RPLC separation. The phosphoproteome coverage was further improved by using two types of instruments, i.e. TripleTOF 5600 and LTQ Orbitrap Velos. A total of 22,446 phosphorylation sites, corresponding to 6526 nonredundant phosphoproteins were finally identified from normal human liver tissues. Of these sites, 15,229 sites were confidently localized with Ascore>/=13. This dataset was the largest phosphoproteome dataset of human liver. It can be a public resource for the liver research community and holds promise for further biology studies. BIOLOGICAL SIGNIFICANCE: The enzyme assisted approach enabled the two RPLC separations operated both with optimized acidic mobile phases. The identifications from TripleTOF 5600 and Orbitrap Velos are highly complementary. The largest phosphoproteome dataset of human liver was generated.

DrugBank Data that Cites this Article

Polypeptides

Name	UniProt ID
Glutaminase liver isoform, mitochondrial	Q9UI32	Details
Estradiol 17-beta-dehydrogenase 2	P37059	Details
Glycogen phosphorylase, liver form	P06737	Details
NAD(P) transhydrogenase, mitochondrial	Q13423	Details
Alcohol dehydrogenase class-3	P11766	Details
Aminomethyltransferase, mitochondrial	P48728	Details
Tyrosine-protein kinase ABL1	P00519	Details
Collagen alpha-1(I) chain	P02452	Details
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial	P56181	Details
7-dehydrocholesterol reductase	Q9UBM7	Details
Dehydrogenase/reductase SDR family member 4	Q9BTZ2	Details
Insulin receptor	P06213	Details
RAF proto-oncogene serine/threonine-protein kinase	P04049	Details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial	O00217	Details
Transketolase	P29401	Details
Pyridoxal kinase	O00764	Details
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating	Q15738	Details
Pyruvate kinase PKLR	P30613	Details
Prothrombin	P00734	Details
High affinity immunoglobulin epsilon receptor subunit gamma	P30273	Details
Delta-aminolevulinic acid dehydratase	P13716	Details
Prolyl 4-hydroxylase subunit alpha-1	P13674	Details
Serine--tRNA ligase, cytoplasmic	P49591	Details
L-lactate dehydrogenase B chain	P07195	Details
Acetyl-CoA acetyltransferase, mitochondrial	P24752	Details
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	Q9HCC0	Details
Alpha-aminoadipic semialdehyde synthase, mitochondrial	Q9UDR5	Details
Growth hormone receptor	P10912	Details
SEC14-like protein 4	Q9UDX3	Details
Hypoxanthine-guanine phosphoribosyltransferase	P00492	Details
Retinoic acid receptor RXR-beta	P28702	Details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial	O95299	Details
Ferritin light chain	P02792	Details
Histidine ammonia-lyase	P42357	Details
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	Q02809	Details
Pyruvate kinase PKM	P14618	Details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5	O43920	Details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial	O75380	Details
Methylsterol monooxygenase 1	Q15800	Details
丙酮酸脱氢酶E1component subunit beta, mitochondrial	P11177	Details
Alanine--glyoxylate aminotransferase 2, mitochondrial	Q9BYV1	Details
Ketimine reductase mu-crystallin	Q14894	Details
Carcinoembryonic antigen-related cell adhesion molecule 1	P13688	Details
Adenine phosphoribosyltransferase	P07741	Details
ATP-binding cassette sub-family A member 1	O95477	Details
3-hydroxyisobutyrate dehydrogenase, mitochondrial	P31937	Details
血红蛋白亚基α	P69905	Details
Androgen receptor	P10275	Details
Aldehyde dehydrogenase, mitochondrial	P05091	Details
Alpha-aminoadipic semialdehyde dehydrogenase	P49419	Details
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	P19404	Details
AFG3-like protein 2	Q9Y4W6	Details
Tubulin beta chain	P07437	Details
NAD-dependent malic enzyme, mitochondrial	P23368	Details
Succinate-semialdehyde dehydrogenase, mitochondrial	P51649	Details
Sigma non-opioid intracellular receptor 1	Q99720	Details
Biotin--protein ligase	P50747	Details
NADH-cytochrome b5 reductase 3	P00387	Details
D-3-phosphoglycerate dehydrogenase	O43175	Details
2-oxoglutarate dehydrogenase, mitochondrial	Q02218	Details
L-serine dehydratase/L-threonine deaminase	P20132	Details
Glutamate--cysteine ligase catalytic subunit	P48506	Details
Cytochrome c oxidase subunit NDUFA4	O00483	Details
Mitochondrial peptide methionine sulfoxide reductase	Q9UJ68	Details
D-beta-hydroxybutyrate dehydrogenase, mitochondrial	Q02338	Details
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	P31040	Details
Carnitine O-palmitoyltransferase 2, mitochondrial	P23786	Details
谷氨酸脱氢酶1,线粒体	P00367	Details
Pyridoxine-5'-phosphate oxidase	Q9NVS9	Details
3-keto-steroid reductase	P56937	Details
Glutathione synthetase	P48637	Details
Bifunctional glutamate/proline--tRNA ligase	P07814	Details
Scavenger receptor class B member 1	Q8WTV0	Details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	O75489	Details
Mitochondrial ornithine transporter 1	Q9Y619	Details
Retinoic acid receptor beta	P10826	Details
Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic	P21695	Details
Plasminogen	P00747	Details
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	Details
Valine--tRNA ligase	P26640	Details
Alcohol dehydrogenase 1A	P07327	Details
Tyrosine--tRNA ligase, cytoplasmic	P54577	Details
Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q02252	Details
Microsomal triglyceride transfer protein large subunit	P55157	Details
Adrenodoxin, mitochondrial	P10109	Details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial	O43674	Details
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial	P30038	Details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10	O96000	Details
Purine nucleoside phosphorylase	P00491	Details
4-aminobutyrate aminotransferase, mitochondrial	P80404	Details
5'-AMP-activated protein kinase subunit beta-1	Q9Y478	Details
SEC14-like protein 2	O76054	Details
Beta-1,4-galactosyltransferase 1	P15291	Details
Trifunctional enzyme subunit alpha, mitochondrial	P40939	Details
Nitric oxide synthase, endothelial	P29474	Details
Gamma-glutamyl hydrolase	Q92820	Details
Neprilysin	P08473	Details
Carbonic anhydrase 1	P00915	Details
Diamine acetyltransferase 2	Q96F10	Details
Solute carrier family 12 member 7	Q9Y666	Details
Calcium-binding mitochondrial carrier protein Aralar2	Q9UJS0	Details
Antithrombin-III	P01008	Details
Sodium-coupled neutral amino acid transporter 3	Q99624	Details
Arginase-1	P05089	Details
4-trimethylaminobutyraldehyde dehydrogenase	P49189	Details
HCG20471, isoform CRA_c	Q5T1J1	Details
Serine hydroxymethyltransferase, mitochondrial	P34897	Details
Alanine--tRNA ligase, cytoplasmic	P49588	Details
Sorbitol dehydrogenase	Q00796	Details
Retinol-binding protein 1	P09455	Details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial	Q16795	Details
Ornithine carbamoyltransferase, mitochondrial	P00480	Details
Retinol-binding protein 4	P02753	Details
Serine--pyruvate aminotransferase	P21549	Details
3-hydroxyacyl-CoA dehydrogenase type-2	Q99714	Details
Methylmalonic aciduria type A protein, mitochondrial	Q8IVH4	Details
Carbonic anhydrase 2	P00918	Details
Cystathionine beta-synthase	P35520	Details
Corticosteroid 11-beta-dehydrogenase isozyme 1	P28845	Details
Serine hydroxymethyltransferase, cytosolic	P34896	Details
Transthyretin	P02766	Details
Glycine amidinotransferase, mitochondrial	P50440	Details
Acetyl-coenzyme A synthetase, cytoplasmic	Q9NR19	Details
Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial	Q96I99	Details
GDH/6PGL endoplasmic bifunctional protein	O95479	Details
Alcohol dehydrogenase 4	P08319	Details
Coagulation factor IX	P00740	Details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8	P51970	Details
Glycine N-methyltransferase	Q14749	Details
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial	Q16836	Details
Calcium signal-modulating cyclophilin ligand	P49069	Details
Vitamin K-dependent protein C	P04070	Details
Dihydroorotate dehydrogenase (quinone), mitochondrial	Q02127	Details
Aspartate aminotransferase, mitochondrial	P00505	Details
Kynureninase	Q16719	Details
Isovaleryl-CoA dehydrogenase, mitochondrial	P26440	Details
Ferritin heavy chain	P02794	Details
Alcohol dehydrogenase 1B	P00325	Details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7	O95182	Details
Vitamin K-dependent gamma-carboxylase	P38435	Details
S-adenosylmethionine synthase isoform type-1	Q00266	Details
Peroxisomal multifunctional enzyme type 2	P51659	Details
Retinoic acid receptor RXR-alpha	P19793	Details
Calmodulin	P0DP23	Details
Annexin A1	P04083	Details
Ornithine aminotransferase, mitochondrial	P04181	Details
L-lactate dehydrogenase A chain	P00338	Details
RAC-alpha serine/threonine-protein kinase	P31749	Details
Methionine-R-sulfoxide reductase B2, mitochondrial	Q9Y3D2	Details
丝氨酸/苏氨酸-protein kinase A-Raf	P10398	Details
Abelson tyrosine-protein kinase 2	P42684	Details
Aldo-keto reductase family 1 member C4	P17516	Details
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial	Q96RQ3	Details
4-hydroxyphenylpyruvate dioxygenase	P32754	Details
Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial	Q96EY8	Details
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	P22413	Details
Alcohol dehydrogenase 1C	P00326	Details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	Q16718	Details
Aldehyde dehydrogenase X, mitochondrial	P30837	Details
Aminoacylase-1	Q03154	Details
Threonine synthase-like 1	Q8IYQ7	Details
ATP synthase subunit delta, mitochondrial	P30049	Details
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	P49821	Details
Isoleucine--tRNA ligase, cytoplasmic	P41252	Details
Propionyl-CoA carboxylase alpha chain, mitochondrial	P05165	Details
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial	P28331	Details
Carnitine O-acetyltransferase	P43155	Details
Low-density lipoprotein receptor	P01130	Details
Serotransferrin	P02787	Details
Receptor tyrosine-protein kinase erbB-2	P04626	Details
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial	O75600	Details
Argininosuccinate lyase	P04424	Details
Nicotinate-nucleotide pyrophosphorylase [carboxylating]	Q15274	Details
Glucagon receptor	P47871	Details
Aspartyl/asparaginyl beta-hydroxylase	Q12797	Details
Aspartate aminotransferase, cytoplasmic	P17174	Details
Serum albumin	P02768	Details
Chromodomain-helicase-DNA-binding protein 1	O14646	Details
Fibrinogen alpha chain	P02671	Details
Dihydropteridine reductase	P09417	Details
Glyceraldehyde-3-phosphate dehydrogenase	P04406	Details
Methionine--tRNA ligase, cytoplasmic	P56192	Details
Propionyl-CoA carboxylase beta chain, mitochondrial	P05166	Details
Acyl carrier protein, mitochondrial	O14561	Details
Sterol 26-hydroxylase, mitochondrial	Q02318	Details
Retinal dehydrogenase 1	P00352	Details
Cationic amino acid transporter 2	P52569	Details
丙酮酸脱氢酶E1component subunit alpha, somatic form, mitochondrial	P08559	Details
Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	P45954	Details
3-hydroxy-3-methylglutaryl-coenzyme A reductase	P04035	Details
Estradiol 17-beta-dehydrogenase 8	Q92506	Details
Mitochondrial carnitine/acylcarnitine carrier protein	O43772	Details
Peroxisomal bifunctional enzyme	Q08426	Details
Heme oxygenase 2	P30519	Details
Malate dehydrogenase, cytoplasmic	P40925	Details
Integrin alpha-4	P13612	Details
Aldo-keto reductase family 1 member C3	P42330	Details
Retinol dehydrogenase 13	Q8NBN7	Details
Flavin reductase (NADPH)	P30043	Details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9	Q9Y6M9	Details
Fatty aldehyde dehydrogenase	P51648	Details
Solute carrier family 12 member 4	Q9UP95	Details
Asparagine--tRNA ligase, cytoplasmic	O43776	Details
N(G),N(G)-dimethylarginine dimethylaminohydrolase 2	O95865	Details
Choline-phosphate cytidylyltransferase A	P49585	Details
C-1-tetrahydrofolate synthase, cytoplasmic	P11586	Details
Glycine dehydrogenase (decarboxylating), mitochondrial	P23378	Details
Acetyl-CoA carboxylase 1	Q13085	Details
Hemoglobin subunit beta	P68871	Details
丝氨酸/苏氨酸-protein kinase B-raf	P15056	Details
Choline dehydrogenase, mitochondrial	Q8NE62	Details
UMP-CMP kinase	P30085	Details
Long-chain-fatty-acid--CoA ligase 1	P33121	Details
Alpha-tocopherol transfer protein	P49638	Details
UDP-glucose 6-dehydrogenase	O60701	Details
Glutathione reductase, mitochondrial	P00390	Details
GDP-L-fucose synthase	Q13630	Details
Alanine aminotransferase 1	P24298	Details
Monocarboxylate transporter 1	P53985	Details
Argininosuccinate synthase	P00966	Details
5'-AMP-activated protein kinase catalytic subunit alpha-1	Q13131	Details
Retinol-binding protein 5	P82980	Details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3	O95167	Details
Tyrosine aminotransferase	P17735	Details
Pyruvate carboxylase, mitochondrial	P11498	Details
Cysteine--tRNA ligase, cytoplasmic	P49589	Details
Acetyl-CoA carboxylase 2	O00763	Details
Bile salt export pump	O95342	Details
ADP/ATP translocase 2	P05141	Details
Inosine-5'-monophosphate dehydrogenase 2	P12268	Details
Aspartate--tRNA ligase, cytoplasmic	P14868	Details
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial	Q8N5Z0	Details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	O75306	Details
Sodium/potassium-transporting ATPase subunit alpha-1	P05023	Details
Dihydrolipoyl dehydrogenase, mitochondrial	P09622	Details
Histidine--tRNA ligase, cytoplasmic	P12081	Details
Biliverdin reductase A	P53004	Details
Fibroblast growth factor receptor 2	P21802	Details
ATPase ASNA1	O43681	Details
Sodium/hydrogen exchanger 1	P19634	Details
Phenylalanine-4-hydroxylase	P00439	Details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12	Q9UI09	Details
Thromboxane A2 receptor	P21731	Details
Short-chain specific acyl-CoA dehydrogenase, mitochondrial	P16219	Details
Methionine synthase reductase	Q9UBK8	Details
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	O94760	Details
Epidermal growth factor receptor	P00533	Details
Leucine--tRNA ligase, cytoplasmic	Q9P2J5	Details
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial	P51553	Details
5'-AMP-activated protein kinase subunit beta-2	O43741	Details
Farnesyl pyrophosphate synthase	P14324	Details
Methylmalonyl-CoA mutase, mitochondrial	P22033	Details
Malate dehydrogenase, mitochondrial	P40926	Details
Nicotinamide N-methyltransferase	P40261	Details
Multidrug resistance-associated protein 1	P33527	Details
Cystathionine gamma-lyase	P32929	Details
Glucocorticoid receptor	P04150	Details
Glutathione S-transferase kappa 1	Q9Y2Q3	Details
Glutathione S-transferase P	P09211	Details
Glutathione S-transferase omega-1	P78417	Details
Glutathione peroxidase 1	P07203	Details
Formimidoyltransferase-cyclodeaminase	O95954	Details
Delta-1-pyrroline-5-carboxylate synthase	P54886	Details
Glutaminase kidney isoform, mitochondrial	O94925	Details
Proto-oncogene tyrosine-protein kinase Src	P12931	Details
Betaine--homocysteine S-methyltransferase 1	Q93088	Details
Macrophage colony-stimulating factor 1 receptor	P07333	Details
Dipeptidyl peptidase 4	P27487	Details
Perilipin-3	O60664	Details
L-xylulose reductase	Q7Z4W1	Details
Dual specificity mitogen-activated protein kinase kinase 1	Q02750	Details
Protein kinase C beta type	P05771	Details
Lanosterol 14-alpha demethylase	Q16850	Details
Lysosomal alpha-glucosidase	P10253	Details
Trifunctional purine biosynthetic protein adenosine-3	P22102	Details
Bile salt sulfotransferase	Q06520	Details
DNA (cytosine-5)-methyltransferase 1	P26358	Details
Cartilage oligomeric matrix protein	P49747	Details
Calpastatin	P20810	Details
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]	P35558	Details
Peroxiredoxin-5, mitochondrial	P30044	Details
Sepiapterin reductase	P35270	Details
Alpha-2-macroglobulin	P01023	Details
Hepatocyte growth factor receptor	P08581	Details
Apolipoprotein A-II	P02652	Details
Mitogen-activated protein kinase 1	P28482	Details
Sulfotransferase 1A1	P50225	Details
Serum paraoxonase/arylesterase 1	P27169	Details
Protein AMBP	P02760	Details
Cytosolic 10-formyltetrahydrofolate dehydrogenase	O75891	Details
Phosphatidylcholine transfer protein	Q9UKL6	Details
Cathepsin B	P07858	Details
Cathepsin D	P07339	Details
Vitamin K-dependent protein S	P07225	Details
Platelet basic protein	P02775	Details
Bifunctional epoxide hydrolase 2	P34913	Details
Alpha-1-antitrypsin	P01009	Details
Cyclic AMP-responsive element-binding protein 1	P16220	Details
Fatty acid synthase	P49327	Details
Dihydropyrimidine dehydrogenase [NADP(+)]	Q12882	Details
Lactoylglutathione lyase	Q04760	Details
Thiamine transporter 2	Q9BZV2	Details
Apoptosis-inducing factor 1, mitochondrial	O95831	Details
DNA topoisomerase 1	P11387	Details
Beta-glucuronidase	P08236	Details
Insulin receptor substrate 1	P35568	Details
Catenin beta-1	P35222	Details
Thiopurine S-methyltransferase	P51580	Details
17-beta-hydroxysteroid dehydrogenase type 6	O14756	Details
Protein deglycase DJ-1	Q99497	Details
Lactotransferrin	P02788	Details
Glycine--tRNA ligase	P41250	Details
Solute carrier organic anion transporter family member 1B1	Q9Y6L6	Details
Cytochrome b-c1 complex subunit 1, mitochondrial	P31930	Details
Cytochrome c	P99999	Details
Calnexin	P27824	Details
Peptidyl-prolyl cis-trans isomerase A	P62937	Details
Rho-associated protein kinase 1	Q13464	Details
Kininogen-1	P01042	Details
Mitogen-activated protein kinase 14	Q16539	Details
G1/S-specific cyclin-D1	P24385	Details
地下室membrane-specific硫酸乙酰肝素proteoglycan core protein	P98160	Details
Ferrochelatase, mitochondrial	P22830	Details
Protein-glutamine gamma-glutamyltransferase 2	P21980	Details
Solute carrier organic anion transporter family member 2B1	O94956	Details
Solute carrier family 2, facilitated glucose transporter member 2	P11168	Details
Solute carrier family 2, facilitated glucose transporter member 1	P11166	Details
Choline transporter-like protein 1	Q8WWI5	Details
Angiotensinogen	P01019	Details
Canalicular multispecific organic anion transporter 2	O15438	Details
Glycogen synthase kinase-3 beta	P49841	Details
Vitronectin	P04004	Details
Canalicular multispecific organic anion transporter 1	Q92887	Details
Somatostatin	P61278	Details
Tyrosine-protein phosphatase non-receptor type 11	Q06124	Details
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1	P16118	Details
Aminopeptidase N	P15144	Details
Intercellular adhesion molecule 1	P05362	Details
Nuclear factor NF-kappa-B p105 subunit	P19838	Details
5'-nucleotidase	P21589	Details
78 kDa glucose-regulated protein	P11021	Details
Microtubule-associated protein 2	P11137	Details
CD44 antigen	P16070	Details
Apolipoprotein E	P02649	Details
Heat shock protein HSP 90-alpha	P07900	Details
Protein kinase C alpha type	P17252	Details
Phospholipid hydroperoxide glutathione peroxidase, mitochondrial	P36969	Details
Ceruloplasmin	P00450	Details
Vitamin D-binding protein	P02774	Details
Protein-L-isoaspartate(D-aspartate) O-methyltransferase	P22061	Details
Methylated-DNA--protein-cysteine methyltransferase	P16455	Details
Beta-hexosaminidase subunit beta	P07686	Details
Inhibitor of nuclear factor kappa-B kinase subunit beta	O14920	Details
Endoplasmin	P14625	Details
Microtubule-associated protein 1A	P78559	Details
Annexin A2	P07355	Details
RAC-beta serine/threonine-protein kinase	P31751	Details
Cytochrome b5	P00167	Details
14-3-3 protein zeta/delta	P63104	Details
Prosaposin	P07602	Details
Phosphatidylethanolamine-binding protein 1	P30086	Details
Fibronectin	P02751	Details
Quinone oxidoreductase	Q08257	Details
3-phosphoinositide-dependent protein kinase 1	O15530	Details
Fatty acid-binding protein, adipocyte	P15090	Details
Glucose-6-phosphate isomerase	P06744	Details
Fibroblast growth factor receptor 4	P22455	Details
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial	P33316	Details
Protein S100-A12	P80511	Details
Catalase	P04040	Details
血清艾米loid P-component	P02743	Details
m7GpppX diphosphatase	Q96C86	Details
Thymidylate kinase	P23919	Details
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q13370	Details
Bifunctional purine biosynthesis protein PURH	P31939	Details
Isocitrate dehydrogenase [NADP] cytoplasmic	O75874	Details
Adenylate kinase isoenzyme 1	P00568	Details
Pleckstrin homology domain-containing family A member 4	Q9H4M7	Details
Apolipoprotein(a)	P08519	Details
Non-secretory ribonuclease	P10153	Details
Acetyl-CoA acetyltransferase, cytosolic	Q9BWD1	Details
MAP kinase-activated protein kinase 2	P49137	Details
Protein kinase C theta type	Q04759	Details
Tubulin alpha-1C chain	Q9BQE3	Details
Tubulin alpha-4A chain	P68366	Details
Tyrosine-protein kinase HCK	P08631	Details
UDP-N-acetylhexosamine pyrophosphorylase	Q16222	Details
丝氨酸/苏氨酸-protein phosphatase PP1-gamma catalytic subunit	P36873	Details
Lanosterol synthase	P48449	Details
Histidine triad nucleotide-binding protein 1	P49773	Details
UDP-glucose 4-epimerase	Q14376	Details
Complement C1s subcomponent	P09871	Details
Methionine aminopeptidase 2	P50579	Details
DNA repair protein XRCC4	Q13426	Details
Coatomer subunit gamma-1	Q9Y678	Details
Cathepsin S	P25774	Details
Sialic acid-binding Ig-like lectin 7	Q9Y286	Details
Ribonuclease UK114	P52758	Details
Leukotriene A-4 hydrolase	P09960	Details
Fructose-bisphosphate aldolase A	P04075	Details
Adenosylhomocysteinase	P23526	Details
Ras-related protein Rab-9A	P51151	Details
Poly [ADP-ribose] polymerase 1	P09874	Details
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial	P11310	Details
Enoyl-CoA delta isomerase 1, mitochondrial	P42126	Details
Death-associated protein kinase 1	P53355	Details
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1	Q9HAN9	Details
Early endosome antigen 1	Q15075	Details
Hydroxyacylglutathione hydrolase, mitochondrial	Q16775	Details
Macrophage migration inhibitory factor	P14174	Details
TGF-beta receptor type-2	P37173	Details
Galectin-10	Q05315	Details
Thromboxane-A synthase	P24557	Details
Heat shock protein HSP 90-beta	P08238	Details
Cyclin-dependent kinase 7	P50613	Details
Glutaryl-CoA dehydrogenase, mitochondrial	Q92947	Details
Peroxiredoxin-2	P32119	Details
Catechol O-methyltransferase	P21964	Details
Fibrinogen beta chain	P02675	Details
Fibrinogen gamma chain	P02679	Details
Complement C1r subcomponent	P00736	Details
Laminin subunit alpha-5	O15230	Details
Tetranectin	P05452	Details
Keratin, type II cytoskeletal 8	P05787	Details
Laminin subunit beta-1	P07942	Details
Laminin subunit gamma-1	P11047	Details
Calreticulin	P27797	Details
Prolow-density lipoprotein receptor-related protein 1	Q07954	Details
Nidogen-1	P14543	Details
Syndecan-2	P34741	Details
Phytanoyl-CoA dioxygenase, peroxisomal	O14832	Details
Asialoglycoprotein receptor 2	P07307	Details
Protein ERGIC-53	P49257	Details
Multiple coagulation factor deficiency protein 2	Q8NI22	Details
Retinoblastoma-associated protein	P06400	Details
Synaptotagmin-like protein 4	Q96C24	Details
Serine protease hepsin	P05981	Details
Neuropilin-1	O14786	Details
Collagen alpha-1(III) chain	P02461	Details
Cathepsin L1	P07711	Details
Collagen alpha-2(I) chain	P08123	Details
Serpin B6	P35237	Details
Proline synthase co-transcribed bacterial homolog protein	O94903	Details
Glycogen phosphorylase, brain form	P11216	Details
Aromatic-L-amino-acid decarboxylase	P20711	Details
Pyridoxal-dependent decarboxylase domain-containing protein 1	Q6P996	Details
5-phosphohydroxy-L-lysine phospho-lyase	Q8IUZ5	Details
Molybdenum cofactor sulfurase	Q96EN8	Details
Serine dehydratase-like	Q96GA7	Details
O-phosphoseryl-tRNA(Sec) selenium transferase	Q9HD40	Details
Methylmalonic aciduria and homocystinuria type C protein	Q9Y4U1	Details
Cholinesterase	P06276	Details
Phospholipase D1	Q13393	Details
Glutathione S-transferase A2	P09210	Details
Thymidine phosphorylase	P19971	Details
Fatty-acid amide hydrolase 1	O00519	Details
Amine oxidase [flavin-containing] B	P27338	Details
Amine oxidase [flavin-containing] A	P21397	Details
Xanthine dehydrogenase/oxidase	P47989	Details
Cyclin-dependent kinase 9	P50750	Details
Multifunctional protein ADE2	P22234	Details
CAD protein	P27708	Details
Adenylosuccinate synthetase isozyme 2	P30520	Details
Aspartate--tRNA ligase, mitochondrial	Q6PI48	Details
Adenylosuccinate synthetase isozyme 1	Q8N142	Details
N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)	Q96HD9	Details
Phosphoribosylformylglycinamidine synthase	O15067	Details
Glutamine synthetase	P15104	Details
Glutamine--tRNA ligase	P47897	Details
S-methylmethionine--homocysteine S-methyltransferase BHMT2	Q9H2M3	Details
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	O14521	Details
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	P21912	Details
Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial	P53597	Details
Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial	Q9P2R7	Details
N-acetyl-D-glucosamine kinase	Q9UJ70	Details
5-oxoprolinase	O14841	Details
Probable glutamate--tRNA ligase, mitochondrial	Q5JPH6	Details
Mitochondrial glutamate carrier 2	Q9H1K4	Details
Mitochondrial glutamate carrier 1	Q9H936	Details
Aspartyl aminopeptidase	Q9ULA0	Details
Microsomal glutathione S-transferase 3	O14880	Details
Thioredoxin domain-containing protein 12	O95881	Details
Glutathione S-transferase A1	P08263	Details
Microsomal glutathione S-transferase 1	P10620	Details
S-formylglutathione hydrolase	P10768	Details
Glutaredoxin-1	P35754	Details
Microsomal glutathione S-transferase 2	Q99735	Details
Phosphatidylserine synthase 2	Q9BVG9	Details
Sphingomyelin phosphodiesterase 3	Q9NY59	Details
Glycine cleavage system H protein, mitochondrial	P23434	Details
Bile acid-CoA:amino acid N-acyltransferase	Q14032	Details
Glycine N-acyltransferase	Q6IB77	Details
Glycine N-acyltransferase-like protein 1	Q969I3	Details
Peroxisomal sarcosine oxidase	Q9P0Z9	Details
Alanine--tRNA ligase, mitochondrial	Q5JTZ9	Details
Short-chain dehydrogenase/reductase 3	O75911	Details
Retinol dehydrogenase 11	Q8TC12	Details
Isoleucine--tRNA ligase, mitochondrial	Q9NSE4	Details
Peptidyl-prolyl cis-trans isomerase B	P23284	Details
Peptidyl-prolyl cis-trans isomerase G	Q13427	Details
Probable proline--tRNA ligase, mitochondrial	Q7L3T8	Details
Probable asparagine--tRNA ligase, mitochondrial	Q96I59	Details
蛋白酶体亚基beta type-5	P28074	Details
Guanylate kinase	Q16774	Details
Cytochrome P450 3A5	P20815	Details
NADPH--cytochrome P450 reductase	P16435	Details
Histone deacetylase 1	Q13547	Details
Histone deacetylase 2	Q92769	Details
Histone deacetylase 6	Q9UBN7	Details
DNA-dependent protein kinase catalytic subunit	P78527	Details
丝氨酸/苏氨酸-protein kinase mTOR	P42345	Details
Nuclear factor NF-kappa-B p100 subunit	Q00653	Details
Superoxide dismutase [Cu-Zn]	P00441	Details
NF-kappa-B essential modulator	Q9Y6K9	Details
Furin	P09958	Details
40S ribosomal protein SA	P08865	Details
Disintegrin and metalloproteinase domain-containing protein 10	O14672	Details
Nicotinamide phosphoribosyltransferase	P43490	Details
DNA-(apurinic or apyrimidinic site) lyase	P27695	Details
Protein kinase C delta type	Q05655	Details
DNA topoisomerase 2-beta	Q02880	Details
Fructose-1,6-bisphosphatase 1	P09467	Details
Cytochrome P450 1A2	P05177	Details
Histamine N-methyltransferase	P50135	Details
Squalene synthase	P37268	Details
Ephrin type-B receptor 4	P54760	Details
Plasma protease C1 inhibitor	P05155	Details
Keratin, type II cytoskeletal 7	P08729	Details
E3 ubiquitin-protein ligase UBR4	Q5T4S7	Details
NAD-dependent protein deacetylase sirtuin-1	Q96EB6	Details
Protein disulfide-isomerase	P07237	Details
Voltage-dependent anion-selective channel protein 1	P21796	Details
Voltage-dependent anion-selective channel protein 2	P45880	Details
N-terminal kinase-like protein	Q96KG9	Details
Prostaglandin E synthase 3	Q15185	Details
Wiskott-Aldrich syndrome protein	P42768	Details
Histone-lysine N-methyltransferase SETD7	Q8WTS6	Details
C-terminal-binding protein 1	Q13363	Details
Cytochrome P450 3A4	P08684	Details
Peripheral plasma membrane protein CASK	O14936	Details
Gephyrin	Q9NQX3	Details
Liver carboxylesterase 1	P23141	Details
U1 small nuclear ribonucleoprotein A	P09012	Details
ATP-dependent Clp protease proteolytic subunit, mitochondrial	Q16740	Details
Protein S100-A11	P31949	Details
Peroxisomal trans-2-enoyl-CoA reductase	Q9BY49	Details
Cytochrome P450 2C9	P11712	Details
Ig gamma-1 chain C region	P01857	Details
Copper transport protein ATOX1	O00244	Details
Estradiol 17-beta-dehydrogenase 11	Q8NBQ5	Details
Beta-2-glycoprotein 1	P02749	Details
Zinc-alpha-2-glycoprotein	P25311	Details
Cytochrome P450 2C8	P10632	Details
Sulfite oxidase, mitochondrial	P51687	Details
Protein S100-A6	P06703	Details
Nucleoside diphosphate kinase A	P15531	Details
2,4-dienoyl-CoA reductase, mitochondrial	Q16698	Details
Hepatocyte nuclear factor 4-gamma	Q14541	Details
Trafficking protein particle complex subunit 3	O43617	Details
Complement component C8 gamma chain	P07360	Details
ADP-ribosylation factor 4	P18085	Details
Nucleoside diphosphate kinase B	P22392	Details
Galactokinase	P51570	Details
Axin-1	O15169	Details
Hydroxymethylglutaryl-CoA lyase, mitochondrial	P35914	Details
Cytochrome P450 2A6	P11509	Details
Calpain-1 catalytic subunit	P07384	Details
NAD-dependent protein deacylase sirtuin-5, mitochondrial	Q9NXA8	Details
Scavenger receptor cysteine-rich type 1 protein M130	Q86VB7	Details
Leptin receptor	P48357	Details
Cytochrome c oxidase subunit 2	P00403	Details
Thioredoxin reductase 2, mitochondrial	Q9NNW7	Details
Amyloid beta A4 protein	P05067	Details
Puromycin-sensitive aminopeptidase	P55786	Details
Bcl-2-like protein 2	Q92843	Details
Bcl2-associated agonist of cell death	Q92934	Details
cAMP-dependent protein kinase type II-alpha regulatory subunit	P13861	Details
cAMP-dependent protein kinase type I-alpha regulatory subunit	P10644	Details
High mobility group protein B1	P09429	Details
Heat shock protein beta-1	P04792	Details
Apolipoprotein A-I	P02647	Details
Complement C3	P01024	Details
T-cell surface glycoprotein CD3 zeta chain	P20963	Details
Signal transducer and activator of transcription 3	P40763	Details
Ribosome-binding protein 1	Q9P2E9	Details
Microtubule-associated protein 4	P27816	Details
Pro-neuropeptide Y	P01303	Details
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2	P16615	Details
HLA class I histocompatibility antigen, A-3 alpha chain	P04439	Details
Alpha-mannosidase 2	Q16706	Details
Transmembrane anterior posterior transformation protein 1 homolog	Q6NXT6	Details
Parathyroid hormone/parathyroid hormone-related peptide receptor	Q03431	Details
Casein kinase I isoform epsilon	P49674	Details
Heat shock factor protein 1	Q00613	Details
Monocyte differentiation antigen CD14	P08571	Details
Histone deacetylase 4	P56524	Details
Histone deacetylase 5	Q9UQL6	Details
Histone deacetylase 7	Q8WUI4	Details
Histone deacetylase 10	Q969S8	Details
Cytochrome P450 2E1	P05181	Details
Cytochrome P450 2C19	P33261	Details
UDP-glucuronosyltransferase 1-9	O60656	Details
Aldehyde oxidase	Q06278	Details
Adenosine kinase	P55263	Details
UDP-glucuronosyltransferase 1-1	P22309	Details
Cytochrome P450 1A1	P04798	Details
UDP-glucuronosyltransferase 1-4	P22310	Details
Alcohol dehydrogenase 6	P28332	Details
Cytochrome P450 2B6	P20813	Details
6-phosphogluconate dehydrogenase, decarboxylating	P52209	Details
Prostaglandin reductase 2	Q8N8N7	Details
Serum paraoxonase/lactonase 3	Q15166	Details
V-type proton ATPase catalytic subunit A	P38606	Details
Integrin beta-1	P05556	Details
Dimethylaniline monooxygenase [N-oxide-forming] 3	P31513	Details
3-oxo-5-beta-steroid 4-dehydrogenase	P51857	Details
DNA polymerase epsilon subunit 4	Q9NR33	Details
Cation-independent mannose-6-phosphate receptor	P11717	Details
Carbonic anhydrase 3	P07451	Details
Carbonic anhydrase 5A, mitochondrial	P35218	Details
Carbonic anhydrase 14	Q9ULX7	Details
Solute carrier family 22 member 1	O15245	Details
Monocarboxylate transporter 10	Q8TF71	Details
Solute carrier organic anion transporter family member 1B3	Q9NPD5	Details
Copper-transporting ATPase 1	Q04656	Details
UDP-glucuronosyltransferase 2B7	P16662	Details
UDP-glucuronosyltransferase 2B17	O75795	Details
UDP-glucuronosyltransferase 2B4	P06133	Details
Cytochrome P450 2J2	P51589	Details
Matrix metalloproteinase-15	P51511	Details
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	P63092	Details
Nuclear receptor coactivator 2	Q15596	Details
Nuclear receptor-interacting protein 1	P48552	Details
丝氨酸/苏氨酸-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform	P30153	Details
Disintegrin and metalloproteinase domain-containing protein 17	P78536	Details
cAMP-dependent protein kinase catalytic subunit alpha	P17612	Details
Hydroxyacid oxidase 1	Q9UJM8	Details
S-phase kinase-associated protein 1	P63208	Details
Heat shock cognate 71 kDa protein	P11142	Details
Beta-2-microglobulin	P61769	Details
Glycylpeptide N-tetradecanoyltransferase 2	O60551	Details
Low molecular weight phosphotyrosine protein phosphatase	P24666	Details
Calcium/calmodulin-dependent protein kinase type II subunit beta	Q13554	Details
Prostaglandin reductase 1	Q14914	Details
丝氨酸/苏氨酸-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform	P63151	Details
Malonyl-CoA-acyl载体蛋白transacylase,麻省理工学院ochondrial	Q8IVS2	Details
ADP-ribosylation factor 1	P84077	Details
60S ribosomal protein L23	P62829	Details
60S ribosomal protein L19	P84098	Details
60S ribosomal protein L23a	P62750	Details
60S ribosomal protein L8	P62917	Details
60S ribosomal protein L3	P39023	Details
60S ribosomal protein L11	P62913	Details
NHP2-like protein 1	P55769	Details
ATP synthase subunit alpha, mitochondrial	P25705	Details
ATP synthase subunit beta, mitochondrial	P06576	Details
ATP synthase subunit gamma, mitochondrial	P36542	Details
Triosephosphate isomerase	P60174	Details
Cytochrome c1, heme protein, mitochondrial	P08574	Details
Cytochrome b-c1 complex subunit 2, mitochondrial	P22695	Details
Cytochrome b-c1 complex subunit 7	P14927	Details
Cytochrome b-c1 complex subunit 9	Q9UDW1	Details
Cytosol aminopeptidase	P28838	Details
Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial	Q16134	Details
Protein kinase C iota type	P41743	Details
Myosin-14	Q7Z406	Details
蛋白酶体亚基alpha type-1	P25786	Details
蛋白酶体亚基alpha type-2	P25787	Details
蛋白酶体亚基alpha type-3	P25788	Details
蛋白酶体亚基alpha type-4	P25789	Details
蛋白酶体亚基alpha type-5	P28066	Details
蛋白酶体亚基alpha type-6	P60900	Details
蛋白酶体亚基alpha type-7	O14818	Details
蛋白酶体亚基beta type-3	P49720	Details
蛋白酶体亚基beta type-4	P28070	Details
蛋白酶体亚基beta type-7	Q99436	Details
Retinoid-inducible serine carboxypeptidase	Q9HB40	Details
Pro-cathepsin H	P09668	Details
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	P13073	Details
Cytochrome c oxidase subunit 5A, mitochondrial	P20674	Details
Cytochrome c oxidase subunit 5B, mitochondrial	P10606	Details
Cytochrome c oxidase subunit 6B1	P14854	Details
Fatty acid-binding protein, liver	P07148	Details
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Q13627	Details
Hepatocyte nuclear factor 4-alpha	P41235	Details
STE20-like serine/threonine-protein kinase	Q9H2G2	Details
Calcium/calmodulin-dependent protein kinase type IV	Q16566	Details
Dual specificity protein kinase CLK3	P49761	Details
Isopentenyl-diphosphate Delta-isomerase 1	Q13907	Details
Nuclear receptor coactivator 5	Q9HCD5	Details
Hydroxymethylglutaryl-CoA synthase, cytoplasmic	Q01581	Details
HLA class I histocompatibility antigen, B-27 alpha chain	P01889	Details
Calcium/calmodulin-dependent protein kinase type II subunit delta	Q13557	Details
丝氨酸/苏氨酸-protein kinase 26	Q9P289	Details
Methionine aminopeptidase 1	P53582	Details
Profilin-1	P07737	Details
Peroxisomal acyl-coenzyme A oxidase 1	Q15067	Details
D-amino-acid oxidase	P14920	Details
Calpain small subunit 1	P04632	Details
Tyrosine-protein kinase JAK1	P23458	Details
Annexin A5	P08758	Details
MKL/myocardin-like protein 1	Q969V6	Details
Gelsolin	P06396	Details
Cofilin-1	P23528	Details
Rho-associated protein kinase 2	O75116	Details
Enoyl-CoA delta isomerase 2, mitochondrial	O75521	Details
ADP-ribosylation factor 6	P62330	Details
Actin-related protein 2/3 complex subunit 1B	O15143	Details
Actin-related protein 2	P61160	Details
Actin-related protein 3	P61158	Details
Actin-related protein 2/3 complex subunit 2	O15144	Details
Actin-related protein 2/3 complex subunit 3	O15145	Details
Actin-related protein 2/3 complex subunit 5	O15511	Details
Ribosomal protein S6 kinase alpha-1	Q15418	Details
Elongation factor 2	P13639	Details
Myosin regulatory light chain 12A	P19105	Details
Tyrosine-protein kinase Lyn	P07948	Details
SRSF protein kinase 2	P78362	Details
Calcium/calmodulin-dependent protein kinase type 1D	Q8IU85	Details
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	Q6NVY1	Details
Glycylpeptide N-tetradecanoyltransferase 1	P30419	Details
Afadin	P55196	Details
丙酮酸脱氢酶(acetyl-transferring)亲属ase isozyme 2, mitochondrial	Q15119	Details
Protein S100-A4	P26447	Details
Alcohol dehydrogenase [NADP(+)]	P14550	Details
CREB-binding protein	Q92793	Details
Iodotyrosine deiodinase 1	Q6PHW0	Details
Acyl-coenzyme A thioesterase 13	Q9NPJ3	Details
Mediator of RNA polymerase II transcription subunit 1	Q15648	Details
Calcium/calmodulin-dependent protein kinase type II subunit gamma	Q13555	Details
tRNA-splicing ligase RtcB homolog	Q9Y3I0	Details
Epsin-1	Q9Y6I3	Details
Superoxide dismutase [Mn], mitochondrial	P04179	Details
Phosphoglycerate kinase 1	P00558	Details
Thiosulfate sulfurtransferase	Q16762	Details
Citrate synthase, mitochondrial	O75390	Details
Beta-enolase	P13929	Details
Phosphoglucomutase-1	P36871	Details
Vimentin	P08670	Details
Uridine 5'-monophosphate synthase	P11172	Details
Cytochrome b5 type B	O43169	Details
cAMP-dependent protein kinase catalytic subunit beta	P22694	Details
Acyl-CoA-binding protein	P07108	Details
腺苷酸激酶2,线粒体	P54819	Details
NADPH:adrenodoxin oxidoreductase, mitochondrial	P22570	Details
Mannose-binding protein C	P11226	Details
Ras-related protein Rab-7a	P51149	Details
Myosin-11	P35749	Details
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	P51178	Details
Galectin-1	P09382	Details
Cation-dependent mannose-6-phosphate受体	P20645	Details
Enoyl-CoA hydratase, mitochondrial	P30084	Details
Signal recognition particle 14 kDa protein	P37108	Details
Aconitate hydratase, mitochondrial	Q99798	Details
Vesicle-fusing ATPase	P46459	Details
Decorin	P07585	Details
Hepatocyte nuclear factor 1-alpha	P20823	Details
Poly(A) polymerase alpha	P51003	Details
Radixin	P35241	Details
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	P26572	Details
6-pyruvoyl tetrahydrobiopterin synthase	Q03393	Details
3-ketoacyl-CoA thiolase, peroxisomal	P09110	Details
Inositol 1,4,5-trisphosphate receptor type 1	Q14643	Details
V-type proton ATPase subunit C 1	P21283	Details
Isocitrate dehydrogenase [NADP], mitochondrial	P48735	Details
Fumarylacetoacetase	P16930	Details
Palmitoyl-protein thioesterase 1	P50897	Details
Elongation factor Tu, mitochondrial	P49411	Details
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	Q9NTG7	Details
Gamma-enolase	P09104	Details
T-complex protein 1 subunit gamma	P49368	Details
Pterin-4-alpha-carbinolamine dehydratase	P61457	Details
GTP-binding nuclear protein Ran	P62826	Details
N-acylneuraminate cytidylyltransferase	Q8NFW8	Details
Fructose-bisphosphate aldolase B	P05062	Details
Carboxypeptidase D	O75976	Details
Acylphosphatase-2	P14621	Details
14-3-3 protein epsilon	P62258	Details
[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	O14874	Details
Transitional endoplasmic reticulum ATPase	P55072	Details
Ubiquitin-like modifier-activating enzyme 1	P22314	Details
Hydroxyacid oxidase 2	Q9NYQ3	Details
Sorting nexin-3	O60493	Details
FAD-linked sulfhydryl oxidase ALR	P55789	Details
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5	O60264	Details
Catechol O-methyltransferase domain-containing protein 1	Q86VU5	Details
Spectrin beta chain, non-erythrocytic 1	Q01082	Details
Spliceosome RNA helicase DDX39B	Q13838	Details
Selenocysteine lyase	Q96I15	Details
Versican core protein	P13611	Details
Ribosomal protein S6 kinase alpha-4	O75676	Details
Hepatocyte growth factor-regulated tyrosine kinase substrate	O14964	Details
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase	Q9BV57	Details
丝氨酸/苏氨酸-protein kinase TAO2	Q9UL54	Details
GTP-binding protein SAR1b	Q9Y6B6	Details
ADP-ribosylation factor-like protein 3	P36405	Details
Peroxiredoxin-6	P30041	Details
Carbamoyl-phosphate synthase [ammonia], mitochondrial	P31327	Details
Coagulation factor XII	P00748	Details
Electrogenic sodium bicarbonate cotransporter 1	Q9Y6R1	Details
UDP-glucuronosyltransferase 1-6	P19224	Details
UDP-glucuronosyltransferase 2B15	P54855	Details
Neutral alpha-glucosidase AB	Q14697	Details
Deoxycytidylate deaminase	P32321	Details
Sodium/nucleoside cotransporter 1	O00337	Details
Cocaine esterase	O00748	Details
Phylloquinone omega-hydroxylase CYP4F2	P78329	Details
蛋白酶体亚基beta type-10	P40306	Details
蛋白酶体亚基beta type-8	P28062	Details
Tyrosine-protein kinase FRK	P42685	Details
Breakpoint cluster region protein	P11274	Details
Dual specificity mitogen-activated protein kinase kinase 2	P36507	Details
Mitogen-activated protein kinase kinase kinase 2	Q9Y2U5	Details
Anoctamin-1	Q5XXA6	Details
ATP-binding cassette sub-family G member 8	Q9H221	Details
RalA-binding protein 1	Q15311	Details
Ethanolamine-phosphate cytidylyltransferase	Q99447	Details
Metallothionein-2	P02795	Details
Adenylate kinase 4, mitochondrial	P27144	Details
Solute carrier family 2, facilitated glucose transporter member 9	Q9NRM0	Details
血清艾米loid A-1 protein	P0DJI8	Details
Transferrin receptor protein 1	P02786	Details
Transferrin receptor protein 2	Q9UP52	Details
Serine-protein kinase ATM	Q13315	Details
Ribosomal protein S6 kinase alpha-3	P51812	Details
Protein kinase C zeta type	Q05513	Details
Membrane-associated progesterone receptor component 1	O00264	Details
Sodium channel protein type 7 subunit alpha	Q01118	Details
Cytochrome b-245 heavy chain	P04839	Details
5'-AMP-activated protein kinase subunit gamma-1	P54619	Details
5'-AMP-activated protein kinase subunit gamma-2	Q9UGJ0	Details
Inositol 1,4,5-trisphosphate receptor type 2	Q14571	Details
Inositol 1,4,5-trisphosphate receptor type 3	Q14573	Details
Cyclic AMP-dependent transcription factor ATF-2	P15336	Details
Cyclic AMP-dependent transcription factor ATF-7	P17544	Details
Complement component 1 Q subcomponent-binding protein, mitochondrial	Q07021	Details
Intracellular hyaluronan-binding protein 4	Q5JVS0	Details
Stabilin-2	Q8WWQ8	Details
Thioredoxin	P10599	Details
Sodium/potassium-transporting ATPase subunit beta-1	P05026	Details
Arsenite methyltransferase	Q9HBK9	Details
载脂蛋白D	P05090	Details
Ig alpha-1 chain C region	P01876	Details
Ig mu chain C region	P01871	Details
Histone H1.4	P10412	Details
Cytoplasmic aconitate hydratase	P21399	Details
Regucalcin	Q15493	Details
Chloride intracellular channel protein 1	O00299	Details
Casein kinase II subunit beta	P67870	Details
C-type lectin domain family 14 member A	Q86T13	Details
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	P60484	Details
Selenoprotein P	P49908	Details
Mitogen-activated protein kinase kinase kinase MLT	Q9NYL2	Details
Dihydropyrimidinase-related protein 2	Q16555	Details
Alpha-enolase	P06733	Details
Protein PML	P29590	Details
Copper chaperone for superoxide dismutase	O14618	Details
Endonuclease 8-like 2	Q969S2	Details
Nucleolar and coiled-body phosphoprotein 1	Q14978	Details
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1	Q15750	Details
Apoptosis regulatory protein Siva	O15304	Details
Utrophin	P46939	Details
Peroxiredoxin-1	Q06830	Details
Apolipoprotein B receptor	Q0VD83	Details
Apolipoprotein C-II	P02655	Details
Apolipoprotein C-III	P02656	Details
Hydroxyacid-oxoacid transhydrogenase, mitochondrial	Q8IWW8	Details
Tricarboxylate transport protein, mitochondrial	P53007	Details
Sodium-dependent phosphate transporter 2	Q08357	Details
Cytochrome c oxidase copper chaperone	Q14061	Details
Sorcin	P30626	Details
Calcineurin B homologous protein 1	Q99653	Details
Translationally-controlled tumor protein	P13693	Details
Nucleobindin-1	Q02818	Details
Nucleobindin-2	P80303	Details
Calmodulin-2	P0DP24	Details
Calmodulin-3	P0DP25	Details
Calreticulin-3	Q96L12	Details
Protein S100-A8	P05109	Details
60 kDa heat shock protein, mitochondrial	P10809	Details
40S ribosomal protein S2	P15880	Details
Heterogeneous nuclear ribonucleoproteins A2/B1	P22626	Details
Heterogeneous nuclear ribonucleoprotein H	P31943	Details
Heterogeneous nuclear ribonucleoprotein H3	P31942	Details
Heterogeneous nuclear ribonucleoprotein L	P14866	Details
Splicing factor, proline- and glutamine-rich	P23246	Details
Receptor of activated protein C kinase 1	P63244	Details
Alpha-actinin-1	P12814	Details
Annexin A4	P09525	Details
Stress-induced-phosphoprotein 1	P31948	Details
Eukaryotic translation initiation factor 6	P56537	Details
Eukaryotic initiation factor 4A-I	P60842	Details
14-3-3 protein beta/alpha	P31946	Details
Hepatoma-derived growth factor	P51858	Details
Proteasome activator complex subunit 1	Q06323	Details
Phosphoglycerate mutase 1	P18669	Details
Ran-specific GTPase-activating protein	P43487	Details
Protein disulfide-isomerase A3	P30101	Details
Serpin B9	P50453	Details
Phosphatidylinositol 4-kinase type 2-beta	Q8TCG2	Details
Integrin alpha-5	P08648	Details
Cystatin-B	P04080	Details
Protein S100-A9	P06702	Details
Huntingtin	P42858	Details
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1	Q8N1G2	Details
巨噬细胞受体马可	Q9UEW3	Details
Minor histocompatibility antigen H13	Q8TCT9	Details
Prohibitin-2	Q99623	Details
Flap endonuclease 1	P39748	Details
Eukaryotic translation initiation factor 3 subunit F	O00303	Details
RuvB-like 2	Q9Y230	Details
Splicing factor 3B subunit 3	Q15393	Details
ATP synthase subunit e, mitochondrial	P56385	Details
ATP synthase subunit g, mitochondrial	O75964	Details
Diablo homolog, mitochondrial	Q9NR28	Details
Heterogeneous nuclear ribonucleoprotein F	P52597	Details
Heterogeneous nuclear ribonucleoprotein K	P61978	Details
Heat shock 70 kDa protein 4	P34932	Details
10 kDa heat shock protein, mitochondrial	P61604	Details
Heat shock protein 105 kDa	Q92598	Details
Nuclear migration protein nudC	Q9Y266	Details
26S protease regulatory subunit 6A	P17980	Details
Protein S100-A10	P60903	Details
Splicing factor 3A subunit 3	Q12874	Details
Tumor protein D54	O43399	Details
Tropomyosin alpha-1 chain	P09493	Details
Tropomyosin alpha-3 chain	P06753	Details
Tropomyosin alpha-4 chain	P67936	Details
Ubiquitin carboxyl-terminal hydrolase 14	P54578	Details
14-3-3 protein eta	Q04917	Details
14-3-3 protein theta	P27348	Details
Proliferating cell nuclear antigen	P12004	Details
Alpha-1B-glycoprotein	P04217	Details
Alpha-2-HS-glycoprotein	P02765	Details
Apolipoprotein A-IV	P06727	Details
C4b-binding protein alpha chain	P04003	Details
Complement component C8 beta chain	P07358	Details
Complement component C9	P02748	Details
Complement factor H	P08603	Details
Complement factor I	P05156	Details
Clusterin	P10909	Details
Chromobox protein homolog 5	P45973	Details
Inter-alpha-trypsin inhibitor heavy chain H2	P19823	Details
Keratin, type II cytoskeletal 1	P04264	Details
角蛋白,我cyt类型oskeletal 10	P13645	Details
Keratin, type II cytoskeletal 2 epidermal	P35908	Details
角蛋白,我cyt类型oskeletal 9	P35527	Details
Leucine-rich alpha-2-glycoprotein	P02750	Details
Lumican	P51884	Details
Apolipoprotein L1	O14791	Details
Complement component C8 alpha chain	P07357	Details
Dermcidin	P81605	Details
Desmoplakin	P15924	Details
Hornerin	Q86YZ3	Details
Inter-alpha-trypsin inhibitor heavy chain H1	P19827	Details
Inter-alpha-trypsin inhibitor heavy chain H4	Q14624	Details
Junction plakoglobin	P14923	Details
角蛋白,我cyt类型oskeletal 14	P02533	Details
角蛋白,我cyt类型oskeletal 16	P08779	Details
Keratin, type II cytoskeletal 5	P13647	Details
Keratin, type II cytoskeletal 6A	P02538	Details
Far upstream element-binding protein 2	Q92945	Details
ATP synthase subunit O, mitochondrial	P48047	Details
Cysteine and glycine-rich protein 1	P21291	Details
Filamin-A	P21333	Details
Heterogeneous nuclear ribonucleoprotein D0	Q14103	Details
Heterochromatin protein 1-binding protein 3	Q5SSJ5	Details
Ras GTPase-activating-like protein IQGAP1	P46940	Details
Nucleophosmin	P06748	Details
60S ribosomal protein L10	P27635	Details
60S ribosomal protein L18	Q07020	Details
60S ribosomal protein L35	P42766	Details
60S ribosomal protein L4	P36578	Details
40S ribosomal protein S13	P62277	Details
40S ribosomal protein S17	P08708	Details
40S ribosomal protein S18	P62269	Details
40S ribosomal protein S28	P62857	Details
40S ribosomal protein S5	P46782	Details
40S ribosomal protein S6	P62753	Details
40S ribosomal protein S8	P62241	Details
40S ribosomal protein S9	P46781	Details
Splicing factor 1	Q15637	Details
Serine/arginine-rich splicing factor 4	Q08170	Details
Transgelin-2	P37802	Details
Zyxin	Q15942	Details
Serine/arginine-rich splicing factor 1	Q07955	Details
Survival motor neuron protein	B4DP61	Details
Transient receptor potential cation channel subfamily V member 2	Q9Y5S1	Details
Transgelin	Q01995	Details
Myosin-9	P35579	Details
Bone morphogenetic protein receptor type-2	Q13873	Details
Beta-ureidopropionase	Q9UBR1	Details
Macrophage mannose receptor 1	P22897	Details
Nuclear receptor subfamily 1 group D member 1	P20393	Details
Splicing factor 3B subunit 1	O75533	Details
丝氨酸/苏氨酸-protein kinase TAO1	Q7L7X3	Details
丝氨酸/苏氨酸-protein kinase TAO3	Q9H2K8	Details
丝氨酸/苏氨酸-protein kinase tousled-like 2	Q86UE8	Details
TRAF2 and NCK-interacting protein kinase	Q9UKE5	Details
Non-receptor tyrosine-protein kinase TNK1	Q13470	Details
AP2-associated protein kinase 1	Q2M2I8	Details
BMP-2-inducible protein kinase	Q9NSY1	Details
Calcium/calmodulin-dependent protein kinase type 1	Q14012	Details
Calcium/calmodulin-dependent protein kinase kinase 1	Q8N5S9	Details
Calcium/calmodulin-dependent protein kinase kinase 2	Q96RR4	Details
Interferon-induced, double-stranded RNA-activated protein kinase	P19525	Details
Tyrosine-protein kinase Fes/Fps	P07332	Details
Cyclin-G-associated kinase	O14976	Details
Glycogen synthase kinase-3 alpha	P49840	Details
Homeodomain-interacting protein kinase 2	Q9H2X6	Details
丝氨酸/苏氨酸-protein kinase SIK3	Q9Y2K2	Details
丝氨酸/苏氨酸-protein kinase LATS1	O95835	Details
Leucine-rich repeat serine/threonine-protein kinase 2	Q5S007	Details
Mitogen-activated protein kinase kinase kinase 11	Q16584	Details
Mitogen-activated protein kinase kinase kinase kinase 2	Q12851	Details
Mitogen-activated protein kinase kinase kinase kinase 4	O95819	Details
Mitogen-activated protein kinase kinase kinase kinase 5	Q9Y4K4	Details
CLIP-associating protein 1	Q7Z460	Details
Misshapen-like kinase 1	Q8N4C8	Details
Myosin light chain kinase, smooth muscle	Q15746	Details
丝氨酸/苏氨酸-protein kinase Nek1	Q96PY6	Details
丝氨酸/苏氨酸-protein kinase Nek3	P51956	Details
丝氨酸/苏氨酸-protein kinase Nek9	Q8TD19	Details
丝氨酸/苏氨酸-protein kinase OSR1	O95747	Details
丝氨酸/苏氨酸-protein kinase PAK 1	Q13153	Details
丝氨酸/苏氨酸-protein kinase PAK 2	Q13177	Details
丝氨酸/苏氨酸-protein kinase PAK 4	O96013	Details
Phosphatidylinositol 4-kinase beta	Q9UBF8	Details
丝氨酸/苏氨酸-protein kinase N1	Q16512	Details
丝氨酸/苏氨酸-protein kinase N2	Q16513	Details
cGMP-dependent protein kinase 2	Q13237	Details
丝氨酸/苏氨酸-protein kinase PRP4 homolog	Q13523	Details
Receptor-interacting serine/threonine-protein kinase 1	Q13546	Details
Receptor-interacting serine/threonine-protein kinase 2	O43353	Details
丝氨酸/苏氨酸-protein kinase SIK2	Q9H0K1	Details
丝氨酸/苏氨酸-protein kinase 10	O94804	Details
Epoxide hydrolase 1	P07099	Details
Alpha-methylacyl-CoA racemase	D6RB81	Details
Insulin-like growth factor-binding protein 1	P08833	Details
Insulin-like growth factor-binding protein 2	P18065	Details
Insulin-like growth factor-binding protein 4	P22692	Details
Inositol polyphosphate 1-phosphatase	P49441	Details
Phosphoenolpyruvate carboxykinase [GTP], mitochondrial	Q16822	Details
Exportin-1	O14980	Details
POU domain, class 2, transcription factor 1	P14859	Details
NAD-dependent protein deacetylase sirtuin-2	Q8IXJ6	Details
HLA class II histocompatibility antigen, DR alpha chain	P01903	Details
N-sulphoglucosamine sulphohydrolase	P51688	Details
Prohibitin	P35232	Details
Dystrophin	P11532	Details
Aflatoxin B1 aldehyde reductase member 3	O95154	Details
P2X purinoceptor 7	Q99572	Details
Histone-lysine N-methyltransferase EZH1	Q92800	Details
ATP-citrate synthase	P53396	Details
Very long-chain acyl-CoA synthetase	O14975	Details
Ectonucleoside triphosphate diphosphohydrolase 5	O75356	Details
Zinc transporter 9	Q6PML9	Details
Zinc transporter SLC39A7	Q92504	Details
Zinc transporter ZIP14	Q15043	Details
Apolipoprotein B-100	P04114	Details
Hemopexin	P02790	Details
Histidine-rich glycoprotein	P04196	Details
Haptoglobin	P00738	Details
Receptor tyrosine-protein kinase erbB-3	P21860	Details
Serum paraoxonase/arylesterase 2	Q15165	Details
Diacylglycerol kinase zeta	Q13574	Details
Tyrosine-protein phosphatase non-receptor type 12	Q05209	Details
V-type proton ATPase 116 kDa subunit a isoform 1	Q93050	Details
V-type proton ATPase subunit E 1	P36543	Details
V-type proton ATPase subunit H	Q9UI12	Details
Mitochondrial potassium channel	Q96ER9	Details
Plasma membrane calcium-transporting ATPase 1	P20020	Details
Plasma membrane calcium-transporting ATPase 2	Q01814	Details
Plasma membrane calcium-transporting ATPase 4	P23634	Details
Beta-galactosidase	P16278	Details
Interleukin-6 receptor subunit beta	P40189	Details
Sphingosine kinase 2	Q9NRA0	Details
Immunoglobulin heavy constant gamma 3	P01860	Details
Leucyl-cystinyl aminopeptidase	Q9UIQ6	Details
Molybdopterin synthase catalytic subunit	O96007	Details
Receptor protein-tyrosine kinase	Q504U8	Details
3-ketoacyl-CoA thiolase, mitochondrial	P42765	Details
Potassium-transporting ATPase alpha chain 2	P54707	Details
HLA class I histocompatibility antigen, C alpha chain	P10321	Details
Arylacetamide deacetylase	P22760	Details
Eukaryotic translation initiation factor 4E-binding protein 1	Q13541	Details
Lysine-specific histone demethylase 1A	O60341	Details
Signal transducer and activator of transcription 1-alpha/beta	P42224	Details
Histone acetyltransferase p300	Q09472	Details
Dual specificity mitogen-activated protein kinase kinase 4	P45985	Details
cAMP-dependent protein kinase type I-beta regulatory subunit	P31321	Details
3-oxoacyl-[acyl-carrier-protein] reductase	Q8N4T8	Details
CD276 antigen	Q5ZPR3	Details
Cytochrome P450 7B1	O75881	Details
Perilipin-1	O60240	Details
Adenylate cyclase type 6	O43306	Details
Adenylate cyclase type 9	O60503	Details
IgG receptor FcRn large subunit p51	P55899	Details
Asialoglycoprotein receptor 1	P07306	Details