3-keto-steroid reductase

Details

Name
3-keto-steroid reductase
Synonyms
  • 1.1.1.270
  • 17-beta-HSD 7
  • 17-beta-hydroxysteroid dehydrogenase 7
  • Estradiol 17-beta-dehydrogenase 7
  • SDR37C1
  • Short chain dehydrogenase/reductase family 37C member 1
Gene Name
HSD17B7
Organism
Humans
Amino acid sequence
>lcl|BSEQ0000367|3-keto-steroid reductase MRKVVLITGASSGIGLALCKRLLAEDDELHLCLACRNMSKAEAVCAALLASHPTAEVTIV QVDVSNLQSVFRASKELKQRFQRLDCIYLNAGIMPNPQLNIKALFFGLFSRKVIHMFSTA EGLLTQGDKITADGLQEVFETNVFGHFILIRELEPLLCHSDNPSQLIWTSSRSARKSNFS LEDFQHSKGKEPYSSSKYATDLLSVALNRNFNQQGLYSNVACPGTALTNLTYGILPPFIW TLLMPAILLLRFFANAFTLTPYNGTEALVWLFHQKPESLNPLIKYLSATTGFGRNYIMTQ KMDLDEDTAEKFYQKLLELEKHIRVTIQKTDNQARLSGSCL
Number of residues
341
分子的重量t
38205.77
Theoretical pI
8.21
GO Classification
Functions
3-keto sterol reductase activity/estradiol 17-beta-dehydrogenase activity
Processes
cholesterol biosynthetic process/estrogen biosynthetic process/small molecule metabolic process
Components
endoplasmic reticulum membrane/integral component of membrane/plasma membrane
General Function
Estradiol 17-beta-dehydrogenase activity
Specific Function
Responsible for the reduction of the keto group on the C-3 of sterols.
Pfam Domain Function
Transmembrane Regions
230-250
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0010193|3-keto-steroid reductase (HSD17B7) ATGCGAAAGGTGGTTTTGATCACCGGGGCTAGCAGTGGCATTGGCCTGGCCCTCTGCAAG CGGCTGCTGGCGGAAGATGATGAGCTTCATCTGTGTTTGGCGTGCAGGAACATGAGCAAG GCAGAAGCTGTCTGTGCTGCTCTGCTGGCCTCTCACCCCACTGCTGAGGTCACCATTGTC CAGGTGGATGTCAGCAACCTGCAGTCGGTCTTCCGGGCCTCCAAGGAACTTAAGCAAAGG TTTCAGAGATTAGACTGTATATATCTAAATGCTGGGATCATGCCTAATCCACAACTAAAT ATCAAAGCACTTTTCTTTGGCCTCTTTTCAAGAAAAGTGATTCATATGTTCTCCACAGCT GAAGGCCTGCTGACCCAGGGTGATAAGATCACTGCTGATGGACTTCAGGAGGTGTTTGAG ACCAATGTCTTTGGCCATTTTATCCTGGTAAAGAAGCTGTGGGCTTAA
Chromosome Location
1
Locus
1q23
External Identifiers
Resource Link
UniProtKB ID P56937
UniProtKB Entry Name DHB7_HUMAN
GenBank Protein ID 6721095
GenBank Gene ID AF098786
GenAtlas ID HSD17B7
HGNC ID HGNC:5215
General References
  1. Krazeisen A, Breitling R, Imai K, Fritz S, Moller G, Adamski J: Determination of cDNA, gene structure and chromosomal localization of the novel human 17beta-hydroxysteroid dehydrogenase type 7(1). FEBS Lett. 1999 Oct 29;460(2):373-9. [Article]
  2. Torn S, Nokelainen P, Kurkela R, Pulkka A, Menjivar M, Ghosh S, Coca-Prados M, Peltoketo H, Isomaa V, Vihko P: Production, purification, and functional analysis of recombinant human and mouse 17beta-hydroxysteroid dehydrogenase type 7. Biochem Biophys Res Commun. 2003 May 23;305(1):37-45. [Article]
  3. Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome Res. 2003 Oct;13(10):2265-70. Epub 2003 Sep 15. [Article]
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Drug Relations

Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details
DB00157 NADH approved, nutraceutical unknown Details