P2Y purinoceptor 1

Details

Name
P2Y purinoceptor 1
Synonyms
  • ADP receptor
  • P2Y1
  • Purinergic receptor
Gene Name
P2RY1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0052215|P2Y purinoceptor 1 MTEVLWPAVPNGTDAAFLAGPGSSWGNSTVASTAAVSSSFKCALTKTGFQFYYLPAVYIL VFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFG DAMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLKSLGRLKKKNAICISVLVWLIVV VAISPILFYSGTGVRKNKTITCYDTTSDEYLRSYFIYSMCTTVAMFCVPLVLILGCYGLI VRALIYKDLDNSPLRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLDFQTPAMCAFND RVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKASRRSEANLQSKSEDMTLN ILPEFKQNGDTSL
Number of residues
373
分子量
42071.08
理论π
Not Available
GO Classification
Functions
A1 adenosine receptor binding/ADP binding/ADP-activated adenosine receptor activity/ATP binding/ATP-activated adenosine receptor activity/G protein-coupled purinergic nucleotide receptor activity/protein heterodimerization activity/scaffold protein binding/signaling receptor activity
Processes
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway/aging/cell surface receptor signaling pathway/cellular response to ATP/cellular response to purine-containing compound/eating behavior/G protein-coupled receptor signaling pathway/神经胶质细胞迁移/negative regulation of binding/negative regulation of norepinephrine secretion/phospholipase C-activating G protein-coupled receptor signaling pathway/platelet activation/positive regulation of cytosolic calcium ion concentration/positive regulation of ERK1 and ERK2 cascade/positive regulation of hormone secretion/positive regulation of inositol trisphosphate biosynthetic process/positive regulation of ion transport/positive regulation of penile erection/positive regulation of protein phosphorylation/positive regulation of transcription by RNA polymerase II/protein localization to plasma membrane/regulation of blood vessel diameter/regulation of cell shape/regulation of presynaptic cytosolic calcium ion concentration/regulation of signaling receptor activity/regulation of synaptic vesicle exocytosis/relaxation of muscle/response to growth factor/response to mechanical stimulus/sensory perception of pain/signal transduction involved in regulation of gene expression
Components
apical plasma membrane/basolateral plasma membrane/cell/cell body/cell surface/cilium/dendrite/glutamatergic synapse/integral component of plasma membrane/integral component of presynaptic active zone membrane/mitochondrion/plasma membrane/postsynaptic density/postsynaptic membrane
General Function
Receptor for extracellular adenine nucleotides such as ADP (PubMed:9442040, PubMed:9038354, PubMed:25822790). In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately platelet aggregation (PubMed:9442040).
Specific Function
A1 adenosine receptor binding
Pfam Domain Function
Transmembrane Regions
52-74 88-109 126-147 167-188 215-237 261-284 304-325
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0052216|P2Y purinoceptor 1 (P2RY1) ATGACCGAGGTGCTGTGGCCGGCTGTCCCCAACGGGACGGACGCTGCCTTCCTGGCCGGT CCGGGTTCGTCCTGGGGGAACAGCACGGTCGCCTCCACTGCCGCCGTCTCCTCGTCGTTC AAATGCGCCTTGACCAAGACGGGCTTCCAGTTTTACTACCTGCCGGCTGTCTACATCTTG GTATTCATCATCGGCTTCCTGGGCAACAGCGTGGCCATCTGGATGTTCGTCTTCCACATG AAGCCCTGGAGCGGCATCTCCGTGTACATGTTCAATTTGGCTCTGGCCGACTTCTTGTAC GTGCTGACTCTGCCAGCCCTGATCTTCTACTACTTCAATAAAACAGACTGGATCTTCGGG GATGCCATGTGTAAACTGCAGAGGTTCATCTTTCATGTGAACCTCTATGGCAGCATCTTG TTTCTGACATGCATCAGTGCCCACCGGTACAGCGGTGTGGTGTACCCCCTCAAGTCCCTG GGCCGGCTCAAAAAGAAGAATGCGATCTGTATCAGCGTGCTGGTGTGGCTCATTGTGGTG GTGGCGATCTCCCCCATCCTCTTCTACTCAGGTACCGGGGTCCGCAAAAACAAAACCATC ACCTGTTACGACACCACCTCAGACGAGTACCTGCGAAGTTATTTCATCTACAGCATGTGC ACGACCGTGGCCATGTTCTGTGTCCCCTTGGTGCTGATTCTGGGCTGTTACGGATTAATT GTGAGAGCTTTGATTTACAAAGATCTGGACAACTCTCCTCTGAGGAGAAAATCGATTTAC CTGGTAATCATTGTACTGACTGTTTTTGCTGTGTCTTACATCCCTTTCCATGTGATGAAA ACGATGAACTTGAGGGCCCGGCTTGATTTTCAGACCCCAGCAATGTGTGCTTTCAATGAC AGGGTTTATGCCACGTATCAGGTGACAAGAGGTCTAGCAAGTCTCAACAGTTGTGTGGAC CCCATTCTCTATTTCTTGGCGGGAGATACTTTCAGAAGGAGACTCTCCCGAGCCACAAGG AAAGCTTCTAGAAGAAGTGAGGCAAATTTGCAATCCAAGAGTGAAGACATGACCCTCAAT ATTTTACCTGAGTTCAAGCAGAATGGAGATACAAGCCTGTGA
Chromosome Location
3
Locus
3q25.2
External Identifiers
Resource Link
UniProtKB ID P47900
UniProtKB Entry Name P2RY1_HUMAN
HGNC ID HGNC:8539
General References
  1. Leon C, Vial C, Cazenave JP, Gachet C: Cloning and sequencing of a human cDNA encoding endothelial P2Y1 purinoceptor. Gene. 1996 Jun 1;171(2):295-7. [Article]
  2. Ayyanathan K, Webbs TE, Sandhu AK, Athwal RS, Barnard EA, Kunapuli SP: Cloning and chromosomal localization of the human P2Y1 purinoceptor. Biochem Biophys Res Commun. 1996 Jan 26;218(3):783-8. [Article]
  3. 詹森R, Communi D, Pirotton S, Samson M, Parmentier M, Boeynaems JM: Cloning and tissue distribution of the human P2Y1 receptor. Biochem Biophys Res Commun. 1996 Apr 25;221(3):588-93. [Article]
  4. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  5. Jin J, Daniel JL, Kunapuli SP: Molecular basis for ADP-induced platelet activation. II. The P2Y1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets. J Biol Chem. 1998 Jan 23;273(4):2030-4. [Article]
  6. Leon C, Hechler B, Vial C, Leray C, Cazenave JP, Gachet C: The P2Y1 receptor is an ADP receptor antagonized by ATP and expressed in platelets and megakaryoblastic cells. FEBS Lett. 1997 Feb 10;403(1):26-30. doi: 10.1016/s0014-5793(97)00022-7. [Article]
  7. Zahedi RP, Lewandrowski U, Wiesner J, Wortelkamp S, Moebius J, Schutz C, Walter U, Gambaryan S, Sickmann A: Phosphoproteome of resting human platelets. J Proteome Res. 2008 Feb;7(2):526-34. Epub 2007 Dec 19. [Article]
  8. Zhang D, Gao ZG, Zhang K, Kiselev E, Crane S, Wang J, Paoletta S, Yi C, Ma L, Zhang W, Han GW, Liu H, Cherezov V, Katritch V, Jiang H, Stevens RC, Jacobson KA, Zhao Q, Wu B: Two disparate ligand-binding sites in the human P2Y1 receptor. Nature. 2015 Apr 16;520(7547):317-21. doi: 10.1038/nature14287. Epub 2015 Mar 30. [Article]

Drug Relations

Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details
DB01069 Promethazine approved, investigational unknown inhibitor Details