Reaction:Ethinylestradiolto1 product

Reaction
Reaction type
2-hydroxylation
Direction
Major circulating metabolite?
No
Spontaneous?
No
交流tivity
unknown
References
  1. Stegeman BH, Vos HL, Helmerhorst FM, Rosendaal FR, Reitsma PH, van Hylckama Vlieg A: Genetic variation in the first-pass metabolism of ethinylestradiol, sex hormone binding globulin levels and venous thrombosis risk. Eur J Intern Med. 2017 Jul;42:54-60. doi: 10.1016/j.ejim.2017.05.019. Epub 2017 Jun 1. [Article]
  2. Ezuruike U, Humphries H, Dickins M, Neuhoff S, Gardner I, Rowland Yeo K: Risk-Benefit Assessment of Ethinylestradiol Using a Physiologically Based Pharmacokinetic Modeling Approach. Clin Pharmacol Ther. 2018 Dec;104(6):1229-1239. doi: 10.1002/cpt.1085. Epub 2018 Apr 27. [Article]
  3. Bolt HM, Kappus H, Kasbohrer R: Metabolism of 17 alpha-ethinylestradiol by human liver microsomes in vitro: aromatic hydroxylation and irreversible protein binding of metabolites. J Clin Endocrinol Metab. 1974 Dec;39(6):1072-80. doi: 10.1210/jcem-39-6-1072. [Article]
Comments
Not Available
Enzymes
Enzyme Km Vmax Role
Cytochrome P450 3A4 Not Available Not Available confirmed
Cytochrome P450 2C8 Not Available Not Available confirmed
Cytochrome P450 2C9 Not Available Not Available confirmed
Cytochrome P450 1A2 Not Available Not Available confirmed
Cytochrome P450 3A5 Not Available Not Available confirmed