Targeting peroxisome proliferator-activated receptors (PPARs): development of modulators.

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Pirat C, Farce A, Lebegue N, Renault N, Furman C, Millet R, Yous S, Speca S, Berthelot P, Desreumaux P, Chavatte P

Targeting peroxisome proliferator-activated receptors (PPARs): development of modulators.

J Med Chem. 2012 May 10;55(9):4027-61. doi: 10.1021/jm101360s. Epub 2012 Feb 27.

PubMed ID

22260081 [View in PubMed

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Abstract

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DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
alpha-Linolenic acid	Peroxisome proliferator-activated receptor gamma	Kd (nM)	2000	N/A	N/A	Details
Clofibrate	Peroxisome proliferator-activated receptor alpha	EC 50 (nM)	55000	N/A	N/A	Details
GW-590735	Peroxisome proliferator-activated receptor alpha	EC 50 (nM)	4	N/A	N/A	Details
Icosapent	Peroxisome proliferator-activated receptor gamma	Kd (nM)	2000	N/A	N/A	Details