Semenogelin-2

Details

Name
Semenogelin-2
Synonyms
  • Semenogelin II
  • SGII
Gene Name
SEMG2
Organism
Humans
Amino acid sequence
>lcl|BSEQ0052389|Semenogelin-2 MKSIILFVLSLLLILEKQAAVMGQKGGSKGQLPSGSSQFPHGQKGQHYFGQKDQQHTKSK GSFSIQHTYHVDINDHDWTRKSQQYDLNALHKATKSKQHLGGSQQLLNYKQEGRDHDKSK GHFHMIVIHHKGGQAHHGTQNPSQDQGNSPSGKGLSSQCSNTEKRLWVHGLSKEQASASG AQKGRTQGGSQSSYVLQTEELVVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHP AHQDRLQHGPKDIFTTQDELLVYNKNQHQTKNLSQDQEHGRKAHKISYPSSRTEERQLHH GEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHLNC GEKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEERRLNS GEKDVQKGVSKGSISIQTEEKIHGKSQNQVTIPSQDQEHGHKENKMSYQSSSTEERRLNY GGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNAKGKSGQSADSKQDLLSH EQKGRYKQESSESHNIVITEHEVAQDDHLTQQYNEDRNPIST
Number of residues
582
Molecular Weight
65444.485
Theoretical pI
Not Available
GO Classification
Functions
protease binding/zinc ion binding
Processes
antibacterial humoral response/coagulation/negative regulation of flagellated sperm motility/positive regulation of serine-type endopeptidase activity/sperm capacitation
Components
extracellular exosome/extracellular space/核
General Function
Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa.
Specific Function
Protease binding
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Secreted
Gene sequence
>拼箱| BSEQ0052390 | Semenogelin-2 (SEMG2)ATGAAGTCCATCATCCTCTTTGTCCTTTCCCTGCTCCTTATCTTGGAGAAGCAAGCAGCT GTGATGGGACAAAAAGGTGGATCAAAAGGCCAATTGCCAAGCGGATCTTCCCAATTTCCA CATGGACAAAAGGGCCAGCACTATTTTGGACAAAAAGACCAACAACATACTAAATCCAAA GGCAGTTTTTCTATTCAACACACATATCATGTAGACATCAATGATCATGACTGGACCCGA AAAAGTCAGCAATATGATTTGAATGCCCTACATAAGGCGACAAAATCAAAACAACACCTA GGTGGAAGTCAACAACTGCTCAATTATAAACAAGAAGGCAGAGACCATGATAAATCAAAA GGTCATTTTCACATGATAGTTATACATCATAAAGGAGGCCAAGCTCATCATGGGACACAA AATCCTTCTCAAGATCAGGGGAATAGCCCATCTGGAAAGGGATTATCCAGTCAATGTTCA AACACAGAAAAAAGGCTATGGGTTCATGGACTAAGTAAAGAACAAGCTTCAGCCTCTGGT GCACAAAAAGGTAGAACACAAGGTGGATCCCAAAGCAGTTATGTTCTCCAAACTGAAGAA CTAGTAGTTAACAAACAACAACGTGAGACTAAAAATTCTCATCAAAATAAAGGGCATTAC CAAAATGTGGTTGACGTGAGAGAGGAACATTCAAGTAAACTACAAACTTCACTCCATCCT GCACATCAAGACAGACTCCAACATGGACCCAAAGACATTTTTACTACCCAAGATGAGCTC CTAGTATATAACAAGAATCAACACCAGACAAAAAATCTCAGTCAAGATCAAGAGCATGGC CGGAAGGCACATAAAATATCATACCCGTCTTCACGTACAGAAGAAAGACAACTTCACCAT GGAGAAAAGAGTGTACAGAAAGATGTATCCAAAGGCAGCATTTCTATCCAAACTGAAGAG AAAATACATGGCAAGTCTCAAAACCAGGTAACAATTCATAGTCAAGATCAAGAGCATGGC CATAAGGAAAATAAAATATCATACCAATCTTCAAGTACAGAAGAAAGACATCTCAACTGT GGAGAAAAGGGCATCCAGAAAGGTGTATCCAAAGGCAGTATTTCGATCCAAACTGAAGAG CAAATACATGGCAAGTCTCAAAACCAGGTAAGAATTCCTAGTCAAGCTCAAGAGTATGGC CATAAGGAAAATAAAATATCATACCAATCTTCGAGTACAGAAGAAAGACGTCTCAACAGT GGAGAAAAGGATGTACAGAAAGGTGTATCCAAAGGCAGTATTTCTATCCAAACTGAAGAG AAAATACATGGCAAGTCTCAAAACCAGGTAACAATTCCTAGTCAAGATCAAGAGCATGGC CATAAGGAAAATAAAATGTCATACCAATCTTCAAGTACAGAAGAAAGACGACTCAACTAT GGAGGAAAGAGCACGCAGAAAGATGTATCCCAAAGCAGTATTTCTTTCCAAATTGAAAAG CTAGTAGAAGGCAAGTCTCAAATCCAGACACCAAATCCTAATCAAGATCAATGGTCTGGC CAAAATGCAAAAGGAAAGTCTGGTCAATCTGCAGATAGCAAACAAGACCTACTCAGTCAT GAACAAAAAGGCAGATACAAACAGGAATCCAGTGAGTCACATAATATTGTAATTACTGAG CATGAGGTTGCCCAAGATGATCATTTGACACAACAATATAATGAAGACAGAAATCCAATA TCTACATAG
Chromosome Location
20
Locus
20q13.12
External Identifiers
Resource Link
UniProtKB ID Q02383
UniProtKB Entry Name SEMG2_HUMAN
HGNC ID HGNC:10743
General References
  1. Lilja H, Lundwall A: Molecular cloning of epididymal and seminal vesicular transcripts encoding a semenogelin-related protein. Proc Natl Acad Sci U S A. 1992 May 15;89(10):4559-63. doi: 10.1073/pnas.89.10.4559. [Article]
  2. Ulvsback M, Lazure C, Lilja H, Spurr NK, Rao VV, Loffler C, Hansmann I, Lundwall A: Gene structure of semenogelin I and II. The predominant proteins in human semen are encoded by two homologous genes on chromosome 20. J Biol Chem. 1992 Sep 5;267(25):18080-4. [Article]
  3. Jensen-Seaman MI, Li WH: Evolution of the hominoid semenogelin genes, the major proteins of ejaculated semen. J Mol Evol. 2003 Sep;57(3):261-70. [Article]
  4. Deloukas P, Matthews LH, Ashurst J, Burton J, Gilbert JG, Jones M, Stavrides G, Almeida JP, Babbage AK, Bagguley CL, Bailey J, Barlow KF, Bates KN, Beard LM, Beare DM, Beasley OP, Bird CP, Blakey SE, Bridgeman AM, Brown AJ, Buck D, Burrill W, Butler AP, Carder C, Carter NP, Chapman JC, Clamp M, Clark G, Clark LN, Clark SY, Clee CM, Clegg S, Cobley VE, Collier RE, Connor R, Corby NR, Coulson A, Coville GJ, Deadman R, Dhami P, Dunn M, Ellington AG, Frankland JA, Fraser A, French L, Garner P, Grafham DV, Griffiths C, Griffiths MN, Gwilliam R, Hall RE, Hammond S, Harley JL, Heath PD, Ho S, Holden JL, Howden PJ, Huckle E, Hunt AR, Hunt SE, Jekosch K, Johnson CM, Johnson D, Kay MP, Kimberley AM, King A, Knights A, Laird GK, Lawlor S, Lehvaslaiho MH, Leversha M, Lloyd C, Lloyd DM, Lovell JD, Marsh VL, Martin SL, McConnachie LJ, McLay K, McMurray AA, Milne S, Mistry D, Moore MJ, Mullikin JC, Nickerson T, Oliver K, Parker A, Patel R, Pearce TA, Peck AI, Phillimore BJ, Prathalingam SR, Plumb RW, Ramsay H, Rice CM, Ross MT, Scott CE, Sehra HK, Shownkeen R, Sims S, Skuce CD, Smith ML, Soderlund C, Steward CA, Sulston JE, Swann M, Sycamore N, Taylor R, Tee L, Thomas DW, Thorpe A, Tracey A, Tromans AC, Vaudin M, Wall M, Wallis JM, Whitehead SL, Whittaker P, Willey DL, Williams L, Williams SA, Wilming L, Wray PW, Hubbard T, Durbin RM, Bentley DR, Beck S, Rogers J: The DNA sequence and comparative analysis of human chromosome 20. Nature. 2001 Dec 20-27;414(6866):865-71. [Article]
  5. Schneider K, Kausler W, Tripier D, Jouvenal K, Spiteller G: [Isolation and structure determination of two peptides occurring in human seminal plasma]. Biol Chem Hoppe Seyler. 1989 Apr;370(4):353-6. [Article]
  6. Malm J, Hellman J, Magnusson H, Laurell CB, Lilja H: Isolation and characterization of the major gel proteins in human semen, semenogelin I and semenogelin II. Eur J Biochem. 1996 May 15;238(1):48-53. doi: 10.1111/j.1432-1033.1996.0048q.x. [Article]
  7. Kise H, Nishioka J, Kawamura J, Suzuki K: Characterization of semenogelin II and its molecular interaction with prostate-specific antigen and protein C inhibitor. Eur J Biochem. 1996 May 15;238(1):88-96. [Article]

Drug Relations

Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details
DB14533 Zinc chloride approved, investigational unknown cofactor Details
DB14548 Zinc sulfate, unspecified form approved, experimental unknown cofactor Details