The DNA sequence and comparative analysis of human chromosome 20.
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Deloukas P, Matthews LH, Ashurst J, Burton J, Gilbert JG, Jones M, Stavrides G, Almeida JP, Babbage AK, Bagguley CL, Bailey J, Barlow KF, Bates KN, Beard LM, Beare DM, Beasley OP, Bird CP, Blakey SE, Bridgeman AM, Brown AJ, Buck D, Burrill W, Butler AP, Carder C, Carter NP, Chapman JC, Clamp M, Clark G, Clark LN, Clark SY, Clee CM, Clegg S, Cobley VE, Collier RE, Connor R, Corby NR, Coulson A, Coville GJ, Deadman R, Dhami P, Dunn M, Ellington AG, Frankland JA, Fraser A, French L, Garner P, Grafham DV, Griffiths C, Griffiths MN, Gwilliam R, Hall RE, Hammond S, Harley JL, Heath PD, Ho S, Holden JL, Howden PJ, Huckle E, Hunt AR, Hunt SE, Jekosch K, Johnson CM, Johnson D, Kay MP, Kimberley AM, King A, Knights A, Laird GK, Lawlor S, Lehvaslaiho MH, Leversha M, Lloyd C, Lloyd DM, Lovell JD, Marsh VL, Martin SL, McConnachie LJ, McLay K, McMurray AA, Milne S, Mistry D, Moore MJ, Mullikin JC, Nickerson T, Oliver K, Parker A, Patel R, Pearce TA, Peck AI, Phillimore BJ, Prathalingam SR, Plumb RW, Ramsay H, Rice CM, Ross MT, Scott CE, Sehra HK, Shownkeen R, Sims S, Skuce CD, Smith ML, Soderlund C, Steward CA, Sulston JE, Swann M, Sycamore N, Taylor R, Tee L, Thomas DW, Thorpe A, Tracey A, Tromans AC, Vaudin M, Wall M, Wallis JM, Whitehead SL, Whittaker P, Willey DL, Williams L, Williams SA, Wilming L, Wray PW, Hubbard T, Durbin RM, Bentley DR, Beck S, Rogers J
The DNA sequence and comparative analysis of human chromosome 20.
Nature. 2001 Dec 20-27;414(6866):865-71.
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11780052 [View in PubMed]
- Abstract
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The finished sequence of human chromosome 20 comprises 59,187,298 base pairs (bp) and represents 99.4% of the euchromatic DNA. A single contig of 26 megabases (Mb) spans the entire short arm, and five contigs separated by gaps totalling 320 kb span the long arm of this metacentric chromosome. An additional 234,339 bp of sequence has been determined within the pericentromeric region of the long arm. We annotated 727 genes and 168 pseudogenes in the sequence. About 64% of these genes have a 5' and a 3' untranslated region and a complete open reading frame. Comparative analysis of the sequence of chromosome 20 to whole-genome shotgun-sequence data of two other vertebrates, the mouse Mus musculus and the puffer fish Tetraodon nigroviridis, provides an independent measure of the efficiency of gene annotation, and indicates that this analysis may account for more than 95% of all coding exons and almost all genes.
DrugBank Data that Cites this Article
- Polypeptides
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Name UniProt ID Tubulin beta-1 chain Q9H4B7 Details Solute carrier family 12 member 5 Q9H2X9 Details Matrix metalloproteinase-9 P14780 Details Prostacyclin synthase Q16647 Details Cysteine desulfurase, mitochondrial Q9Y697 Details Glutathione synthetase P48637 Details Acetyl-coenzyme A synthetase, cytoplasmic Q9NR19 Details Synaptosomal-associated protein 25 P60880 Details Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial O43837 Details Spermine oxidase Q9NWM0 Details Solute carrier family 13 member 3 Q8WWT9 Details Tyrosine-protein phosphatase non-receptor type 1 P18031 Details Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 Details Alpha-1D adrenergic receptor P25100 Details Acetyl-coenzyme A synthetase 2-like, mitochondrial Q9NUB1 Details Oxytocin-neurophysin 1 P01178 Details Proto-oncogene tyrosine-protein kinase Src P12931 Details Neuronal acetylcholine receptor subunit alpha-4 P43681 Details Potassium voltage-gated channel subfamily KQT member 2 O43526 Details Phosphoenolpyruvate carboxykinase, cytosolic [GTP] P35558 Details Histamine H3 receptor Q9Y5N1 Details DNA topoisomerase 1 P11387 Details Aurora kinase A O14965 Details Protein-glutamine gamma-glutamyltransferase 2 P21980 Details Major prion protein P04156 Details Bactericidal permeability-increasing protein P17213 Details Thrombomodulin P07204 Details Endothelial protein C receptor Q9UNN8 Details Tumor necrosis factor receptor superfamily member 5 P25942 Details Casein kinase II subunit alpha P68400 Details Protein-glutamine gamma-glutamyltransferase E Q08188 Details Tyrosine-protein kinase HCK P08631 Details Adenosylhomocysteinase P23526 Details M-phase inducer phosphatase 2 P30305 Details Laminin subunit alpha-5 O15230 Details Neuroendocrine convertase 2 P16519 Details Glycogen phosphorylase, brain form P11216 Details Serine palmitoyltransferase 3 Q9NUV7 Details Adenosine deaminase P00813 Details Protein-glutamine gamma-glutamyltransferase 6 O95932 Details 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial Q07973 Details Vesicular inhibitory amino acid transporter Q9H598 Details Nociceptin receptor P41146 Details Growth/differentiation factor 5 P43026 Details Lethal(3)malignant brain tumor-like protein 1 Q9Y468 Details Ribosome-binding protein 1 Q9P2E9 Details Bcl-2-like protein 1 Q07817 Details Troponin C, skeletal muscle P02585 Details Solute carrier organic anion transporter family member 4A1 Q96BD0 Details Matrix metalloproteinase-24 Q9Y5R2 Details Guanine nucleotide-binding protein G(s) subunit alpha isoforms short P63092 Details Hydroxyacid oxidase 1 Q9UJM8 Details 蛋白酶体子unit alpha type-7 O14818 Details Hepatocyte nuclear factor 4-alpha P41235 Details Nuclear receptor coactivator 5 Q9HCD5 Details Destrin P60981 Details Inosine triphosphate pyrophosphatase Q9BY32 Details Uridine-cytidine kinase-like 1 Q9NWZ5 Details Sialoadhesin Q9BZZ2 Details Potassium voltage-gated channel subfamily B member 1 Q14721 Details Protein-tyrosine kinase 6 Q13882 Details Myosin light chain kinase 2, skeletal/cardiac muscle Q9H1R3 Details Solute carrier family 2, facilitated glucose transporter member 10 O95528 Details CCAAT/enhancer-binding protein beta P17676 Details Semenogelin-1 P04279 Details Lysosomal protective protein P10619 Details Eukaryotic translation initiation factor 6 P56537 Details 14-3-3 protein beta/alpha P31946 Details Alternative prion protein F7VJQ1 Details Copine-1 Q99829 Details Minor histocompatibility antigen H13 Q8TCT9 Details Tumor protein D54 O43399 Details Proliferating cell nuclear antigen P12004 Details Somatostatin receptor type 4 P31391 Details Serine/threonine-protein kinase 35 Q8TDR2 Details Serine/threonine-protein kinase PAK 5 Q9P286 Details Tyrosine-protein kinase Srms Q9H3Y6 Details Phospholipid transfer protein P55058 Details Melanocortin receptor 3 P41968 Details Potassium voltage-gated channel subfamily S member 1 Q96KK3 Details Potassium voltage-gated channel subfamily G member 1 Q9UIX4 Details Solute carrier family 23 member 2 Q9UGH3 Details Semenogelin-2 Q02383 Details DNA (cytosine-5)-methyltransferase 3B Q9UBC3 Details Bone morphogenetic protein 2 P12643 Details