Potassium voltage-gated channel subfamily G member 1

Details

Name
Potassium voltage-gated channel subfamily G member 1
Synonyms
  • kH2
  • Voltage-gated potassium channel subunit Kv6.1
Gene Name
KCNG1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0052255|Potassium voltage-gated channel subfamily G member 1 MTLLPGDNSDYDYSALSCTSDASFHPAFLPQRQAIKGAFYRRAQRLRPQDEPRQGCQPED RRRRIIINVGGIKYSLPWTTLDEFPLTRLGQLKACTNFDDILNVCDDYDVTCNEFFFDRN PGAFGTILTFLRAGKLRLLREMCALSFQEELLYWGIAEDHLDGCCKRRYLQKIEEFAEMV EREEEDDALDSEGRDSEGPAEGEGRLGRCMRRLRDMVERPHSGLPGKVFACLSVLFVTVT AVNLSVSTLPSLREEEEQGHCSQMCHNVFIVESVCVGWFSLEFLLRLIQAPSKFAFLRSP LTLIDLVAILPYYITLLVDGAAAGRRKPGAGNSYLDKVGLVLRVLRALRILYVMRLARHS LGLQTLGLTARRCTREFGLLLLFLCVAIALFAPLLYVIENEMADSPEFTSIPACYWWAVI TMTTVGYGDMVPRSTPGQVVALSSILSGILLMAFPVTSIFHTFSRSYLELKQEQERVMFR RAQFLIKTKSQLSVSQDSDILFGSASSDTRDNN
Number of residues
513
分子量
57912.07
Theoretical pI
Not Available
GO Classification
Functions
delayed rectifier potassium channel activity/potassium channel activity/voltage-gated potassium channel activity
Processes
potassium ion transmembrane transport/potassium ion transport/protein homooligomerization/regulation of delayed rectifier potassium channel activity
Components
integral component of membrane/plasma membrane/voltage-gated potassium channel complex
General Function
Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 (PubMed:19074135).
Specific Function
Delayed rectifier potassium channel activity
Pfam Domain Function
Transmembrane Regions
225-246 268-289 301-321 339-359 375-396 439-467
细胞ular Location
细胞membrane
Gene sequence
>拼箱| BSEQ0052256 |电压门控钾通道ubfamily G member 1 (KCNG1) ATGACCCTCTTACCGGGAGACAATTCTGACTACGACTACAGCGCGCTGAGCTGCACCTCG GACGCCTCCTTCCACCCGGCCTTCCTCCCGCAGCGCCAGGCCATCAAGGGCGCGTTCTAC CGCCGGGCGCAGCGGCTGCGGCCGCAGGATGAGCCCCGCCAGGGCTGTCAGCCCGAGGAC CGCCGCCGTCGGATCATCATCAACGTAGGCGGCATCAAGTACTCGCTGCCCTGGACCACG CTGGACGAGTTCCCGCTGACGCGCCTGGGCCAGCTCAAGGCCTGCACCAACTTCGACGAC ATCCTCAACGTGTGCGATGACTACGACGTCACCTGCAACGAGTTCTTCTTCGACCGCAAC CCGGGGGCCTTCGGCACTATCCTGACCTTCCTGCGCGCGGGCAAGCTGCGGCTGCTGCGC GAGATGTGCGCGCTGTCCTTCCAGGAGGAGCTGCTGTACTGGGGCATCGCGGAGGACCAC CTGGACGGCTGCTGCAAGCGCCGCTACCTGCAGAAGATTGAGGAGTTCGCGGAGATGGTG GAGCGGGAGGAAGAGGACGACGCGCTGGACAGCGAGGGCCGCGACAGCGAGGGCCCGGCC GAGGGCGAGGGCCGCCTGGGGCGCTGCATGCGGCGACTGCGCGACATGGTGGAGAGGCCG CACTCGGGGCTGCCTGGCAAGGTGTTCGCCTGCCTGTCGGTGCTCTTCGTGACCGTCACC GCCGTCAACCTCTCCGTCAGCACCTTGCCCAGCCTGAGGGAGGAGGAGGAGCAGGGCCAC TGTTCCCAGATGTGCCACAACGTCTTCATCGTGGAGTCGGTGTGCGTGGGCTGGTTCTCC CTGGAGTTCCTCCTGCGGCTCATTCAGGCGCCCAGCAAGTTCGCCTTCCTGCGGAGCCCG CTGACGCTGATCGACCTGGTGGCCATCCTGCCCTACTACATCACGCTGCTGGTGGACGGC GCCGCCGCAGGCCGTCGCAAGCCCGGCGCGGGCAACAGCTACCTGGACAAGGTGGGGCTG GTGCTGCGCGTGCTGCGGGCGCTGCGCATCCTGTACGTGATGCGCCTGGCGCGCCACTCC CTGGGGCTGCAGACGCTGGGGCTCACGGCCCGCCGCTGCACCCGCGAGTTCGGGCTCCTG CTGCTCTTCCTCTGCGTGGCCATCGCCCTCTTCGCGCCCCTGCTCTACGTCATCGAGAAC GAGATGGCCGACAGCCCCGAGTTCACCAGCATCCCTGCCTGCTACTGGTGGGCTGTCATC ACCATGACGACGGTGGGCTATGGCGACATGGTCCCCAGGAGCACCCCGGGCCAGGTAGTG GCCCTGAGCAGCATCCTGAGCGGCATCCTGCTCATGGCCTTCCCAGTCACCTCCATCTTC CACACCTTCTCCCGCTCCTACCTGGAGCTCAAGCAGGAGCAAGAGAGGGTGATGTTCCGG AGGGCGCAGTTCCTCATCAAAACCAAGTCGCAGCTGAGCGTGTCCCAGGACAGTGACATC TTGTTCGGAAGTGCCTCCTCGGACACCAGAGACAATAACTGA
Chromosome Location
20
Locus
20q13.13
External Identifiers
Resource Link
UniProtKB ID Q9UIX4
UniProtKB Entry Name KCNG1_HUMAN
HGNC ID HGNC: 6248
General References
  1. Su K, Kyaw H, Fan P, Zeng Z, Shell BK, Carter KC, Li Y: Isolation, characterization, and mapping of two human potassium channels. Biochem Biophys Res Commun. 1997 Dec 29;241(3):675-81. [Article]
  2. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
  3. Deloukas P, Matthews LH, Ashurst J, Burton J, Gilbert JG, Jones M, Stavrides G, Almeida JP, Babbage AK, Bagguley CL, Bailey J, Barlow KF, Bates KN, Beard LM, Beare DM, Beasley OP, Bird CP, Blakey SE, Bridgeman AM, Brown AJ, Buck D, Burrill W, Butler AP, Carder C, Carter NP, Chapman JC, Clamp M, Clark G, Clark LN, Clark SY, Clee CM, Clegg S, Cobley VE, Collier RE, Connor R, Corby NR, Coulson A, Coville GJ, Deadman R, Dhami P, Dunn M, Ellington AG, Frankland JA, Fraser A, French L, Garner P, Grafham DV, Griffiths C, Griffiths MN, Gwilliam R, Hall RE, Hammond S, Harley JL, Heath PD, Ho S, Holden JL, Howden PJ, Huckle E, Hunt AR, Hunt SE, Jekosch K, Johnson CM, Johnson D, Kay MP, Kimberley AM, King A, Knights A, Laird GK, Lawlor S, Lehvaslaiho MH, Leversha M, Lloyd C, Lloyd DM, Lovell JD, Marsh VL, Martin SL, McConnachie LJ, McLay K, McMurray AA, Milne S, Mistry D, Moore MJ, Mullikin JC, Nickerson T, Oliver K, Parker A, Patel R, Pearce TA, Peck AI, Phillimore BJ, Prathalingam SR, Plumb RW, Ramsay H, Rice CM, Ross MT, Scott CE, Sehra HK, Shownkeen R, Sims S, Skuce CD, Smith ML, Soderlund C, Steward CA, Sulston JE, Swann M, Sycamore N, Taylor R, Tee L, Thomas DW, Thorpe A, Tracey A, Tromans AC, Vaudin M, Wall M, Wallis JM, Whitehead SL, Whittaker P, Willey DL, Williams L, Williams SA, Wilming L, Wray PW, Hubbard T, Durbin RM, Bentley DR, Beck S, Rogers J: The DNA sequence and comparative analysis of human chromosome 20. Nature. 2001 Dec 20-27;414(6866):865-71. [Article]
  4. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  5. Mederos Y Schnitzler M, Rinne S, Skrobek L, Renigunta V, Schlichthorl G, Derst C, Gudermann T, Daut J, Preisig-Muller R: Mutation of histidine 105 in the T1 domain of the potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4. J Biol Chem. 2009 Feb 13;284(7):4695-704. doi: 10.1074/jbc.M808786200. Epub 2008 Dec 11. [Article]

Drug Relations

Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details
DB00228 Enflurane approved, investigational, vet_approved unknown inhibitoractivator Details
DB01069 Promethazine approved, investigational unknown inducer Details
DB01110 Miconazole approved, investigational, vet_approved unknown inhibitor Details