干扰素治疗慢性丙型肝炎的副作用。
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Dusheiko G
干扰素治疗慢性丙型肝炎的副作用。
国际肝病杂志，1997年9月26日(3增刊1):112S-121S。
- PubMed ID
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9305675 (PubMed视图］
- 摘要
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α干扰素已被广泛用于治疗慢性丙型肝炎病毒感染。这些干扰素包括重组干扰素、纯化的天然白细胞和淋巴母细胞干扰素。Alpha干扰素通过皮下注射或肌肉注射，每天或每周注射三次，为期6至24个月。α干扰素的一系列广泛的不良反应已被描述。一些副作用，如发烧，头痛疲劳，关节痛和肌痛是常见的，特别是在最初的注射。干扰素的这些早期副作用是可预测的，大多数患者都会遇到。这些药物可能不需要调整剂量，但对很大一部分患者来说可能存在问题。在2% - 10%的患者中，其他不良事件影响可能需要调整剂量甚至停止治疗。神经精神方面的副作用，如抑郁和易怒，可能是最麻烦的;它们的机制还没有被很好地理解。 Granulocytes, platelets, and red blood cell counts decrease during treatment, but the decreases are usually mild, although they can be dose limiting if cell counts are low initially. Interferon has important immunomodulatory properties, and treatment can induce autoimmune phenomena, the most frequent being autoimmune thyroiditis with either hypothyroidism or hyperthyroidism, especially in predisposed patients. Other autoimmune disease can be aggravated by interferon therapy. Severe and even life-threatening side effects of interferon occur in 0.1% to 1% of patients; these include thyroid, visual, auditory, renal, and cardiac impairment, and pulmonary interstitial fibrosis. Some of these side effects may be irreversible. Higher doses of interferon (above 5 million units three times weekly) cause higher rates of adverse events than standard doses. Contraindications to alpha interferon have been recognized.
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