Phenytoin-diazepam交互。
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墨菲,Wilbur K
Phenytoin-diazepam交互。
安Pharmacother。2003年5月,37 (5):659 - 63。doi: 10.1345 / aph.1C413。
- PubMed ID
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12708941 (在PubMed]
- 文摘
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目的:报告一例苯妥英的毒性可能与并发安定治疗有关。案例总结:44岁的“第一民族”人了急诊科的头痛、眼球震颤、复视、共济失调。除了长期癫痫发作,他过去病史是不起眼的。苯妥英的抗癫痫药物,苯巴比妥,拉莫三嗪已近5个月不变。总苯妥英血清浓度报道前2周住院8微g / L。入学前两天,他规定阿莫西林和安定;他否认使用非处方药物或草药。血清浓度苯妥英拉在医院是37微g / mL。苯妥英和安定都停止,症状得到解决。他的神经系统异常是由苯妥英毒性引起的与安定的交互。 DISCUSSION: The literature documenting a potential interaction between diazepam and phenytoin is conflicting. Case reports and controlled studies have demonstrated both increases and decreases in serum phenytoin concentrations when these agents were administered concomitantly. Phenytoin induces the metabolism of drugs that are substrates of CYP2C, CYP2D, and CYP3A; however, phenytoin is eliminated predominantly by CYP2C9- and CYP2C19-dependent hepatic metabolism. Diazepam is one example of a drug that is extensively metabolized by CYP2C19 and could potentially influence phenytoin elimination by acting as an alternate substrate for this isoenzyme. In our patient, the timing of drug administration, clinical and physical examination findings, and laboratory data suggest that diazepam therapy resulted in phenytoin toxicity. Use of the Naranjo probability scale indicated a probable relationship between the adverse clinical effects observed and phenytoin and diazepam coadministration in this patient. CONCLUSIONS: Phenytoin is a known inducer of drugs metabolized by CYP2C, CYP2D, and CYP3A, but its own metabolism may be altered by drugs influencing CYP2C9 or CYP2C19, such as diazepam. Agents not acting as enzyme inhibitors or inducers, but instead behaving as alternate substrates for enzyme-binding sites, may produce clinically relevant drug interactions through an underrecognized mechanism.
beplay体育安全吗DrugBank数据引用了这篇文章
- 药物酶
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药物 酶 类 生物 药理作用 行动 安定 细胞色素P450 2 c19 蛋白质 人类 未知的底物抑制剂细节 - 药物的相互作用Learn More" title="" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">
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药物 交互 整合药物之间
在您的软件的交互Fosphenytoin Halazepam 的血清浓度Fosphenytoin时可以增加与Halazepam相结合。 Fosphenytoin Camazepam 的血清浓度Fosphenytoin时可以增加与Camazepam相结合。 Fosphenytoin 地洛西泮 的血清浓度Fosphenytoin结合时可以增加地洛西泮。 Fosphenytoin 乙loflazepate 的血清浓度Fosphenytoin时可以增加与乙基loflazepate相结合。 Fosphenytoin Cloxazolam 的血清浓度Fosphenytoin时可以增加与Cloxazolam相结合。 Fosphenytoin 氟安定 的血清浓度Fosphenytoin时可以增加结合氟安定。 Fosphenytoin Cinolazepam 的血清浓度Fosphenytoin时可以增加与Cinolazepam相结合。 Fosphenytoin Pinazepam 的血清浓度Fosphenytoin时可以增加与Pinazepam相结合。 Fosphenytoin Medazepam 的血清浓度Fosphenytoin时可以增加与Medazepam相结合。 Fosphenytoin Loprazolam 的血清浓度Fosphenytoin时可以增加与Loprazolam相结合。
