Antiemetics

Name
Antiemetics
Accession Number
DBCAT000454
Description

Drugs used to prevent NAUSEA or VOMITING.

Drugs
Drug Drug Description
Trimethobenzamide An antiemetic used to treat postoperative nausea and vomiting and nausea associated with gastroenteritis.
Meclizine A histamine H1 antagonist used to treat nausea, vomiting, and dizziness associated with motion sickness.
Lorazepam A short-acting benzodiazepine commonly used to treat panic disorders, severe anxiety, and seizures.
Olanzapine An antipsychotic drug used in the management of schizophrenia, bipolar 1 disorder, and agitation associated with these disorders.
Doxylamine An antihistamine used to treat insomnia and allergy symptoms and is used with pyridoxine in the treatment of nausea and vomiting in pregnancy.
Thiethylperazine A drug used for the treatment of nausea and vomiting.
Promazine A phenothiazine used to manage schizophrenia.
Prochlorperazine A phenothiazine derivative used in the treatment of schizophrenia and anxiety and to relieve severe nausea and vomiting.
Droperidol A butyrophenone derivative and dopamine antagonist used to prevent and treat postoperative nausea and vomiting.
Chlorpromazine A phenothiazine antipsychotic used to treat nausea, vomiting, preoperative anxiety, schizophrenia, bipolar disorder, and severe behavioral problems in children.
Nabilone A synthetic delta-9-THC used in the treatment of anorexia and weight loss in HIV patients as well as nausea and vomiting in cancer chemotherapy.
Haloperidol An antipsychotic agent used to treat schizophrenia and other psychoses, as well as symptoms of agitation, irritability, and delirium.
Triflupromazine Used mainly in the management of psychoses. Also used to control nausea and vomiting.
Aprepitant A substance P/neurokinin 1 receptor antagonist used to treat nausea and vomiting caused by chemotherapy and surgery.
Dolasetron An antinauseant and antiemetic used in chemotherapy and postoperatively.
Trifluoperazine A phenothiazine used to treat depression, anxiety, and agitation.
Granisetron A 5HT3 antagonist used to treat nausea and vomiting in cancer therapy and postoperatively.
Ondansetron A serotonin 5-HT3 receptor antagonist used to prevent nausea and vomiting in cancer chemotherapy and postoperatively.
Methylprednisolone A corticosteroid used to treat inflammation or immune reactions across a variety of organ systems, endocrine conditions, and neoplastic diseases.
Dimenhydrinate A medication used to prevent and treat nausea, vomiting, vertigo, and motion sickness.
Cyclizine An antihistamine and antiemetic drug used for the prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness, and vertigo.
Domperidone A dopamine receptor antagonist used as a peristaltic stimulant and anti-emetic agent for dyspepsia, indigestion, epigastric pain, nausea, and vomiting.
Diphenidol An antiemetic agent used for the prevention and symptomatic treatment of nausea and vomiting associated with various conditions as Meniere's disease and surgery of the middle and inner ear.
Metoclopramide An antiemetic agent and dopamine D2 antagonist used in the treatment of gastroesophageal reflux disease, prevention of nausea and vomiting, and to stimulate gastric emptying.
Dexamethasone A glucocorticoid available in various modes of administration that is used for the treatment of various inflammatory conditions, including bronchial asthma, as well as endocrine and rheumatic disorders.
Alizapride A dopamine antagonist used to prevent nausea and vomiting associated with medical procedures, surgeries, and cancer therapies.
Dexanabinol Investigated for use/treatment in traumatic brain injuries and neurologic disorders.
Casopitant Investigated for use/treatment in urinary incontinence and adverse effects (chemotherapy).
Fosaprepitant An antiemetic drug used in combination with other antiemetic agents for the prevention of acute and delayed nausea and vomiting caused by chemotherapy.
Bromopride A substituted benzamide, closely related to metoclopramide, used as an antiemetic.
Ramosetron A selective 5-HT3 antagonist used as an antiemetic for chemotherapy- and postoperative-associated nausea and vomiting. It may also possess efficacy in irritable bowel syndrome.
Peppermint oil An ingredient used in a variety of natural health products and is not an approved medication.
Tropisetron A 5HT-3 receptor antagonist used as an antiemetic in the treatment of chemotherapy-induced nausea and vomiting.
Vofopitant Vofopitant has been used in trials studying the treatment of PTSD, Primary Insomnia, and Sleep Initiation and Maintenance Disorders.
Clebopride A dopamine antagonist used to treat symptoms associated with functional gastrointestinal disorders. Clebopride may also be used to treat nausea and vomiting associated with chemotherapy.
Metopimazine Not Annotated
Dixyrazine Not Annotated
Palonosetron A serotonin antagonist used in the prophylaxis or management of vomiting that results from emetogenic chemotherapy, and for the management of postoperative nausea and vomiting.
Diphenhydramine A H1 receptor antihistamine used in the treatment of seasonal allergies, and various allergic reactions including sneezing, runny nose, itchy/watery eyes, itching of nose or throat, pruritus, urticaria, insect bites/stings, and allergic rashes.
Scopolamine A belladonna alkaloid with anticholinergic effects indicated for the treatment of nausea and vomiting associated with motion sickness and postoperative nausea and vomiting (PONV).
Maropitant Maropitant, used as maropitant citrate, is a neurokinin receptor antagonist, which was developed by Zoetis specifically for the treatment of motion sickness and vomiting in dogs. It was approved by...
Amisulpride 多巴胺D2受体拮抗剂用于胎面tment of acute and chronic schizophrenia, and in the prevention and treatment of postoperative nausea and vomiting in adults.
Azasetron Not Annotated
Alosetron A 5-HT3 antagonist used to treat diarrhea-predominant IBS.
Drugs & Drug Targets
Drug Target Type
Meclizine Histamine H1 receptor target
Meclizine Nuclear receptor subfamily 1 group I member 3 target
Meclizine 阶段chrome P450 2D6 enzyme
Meclizine Serum albumin carrier
Lorazepam UDP-glucuronosyltransferase 2B15 enzyme
Lorazepam GABA(A) Receptor target
Lorazepam 阶段chrome P450 3A4 enzyme
Lorazepam GABA(A) Receptor Benzodiazepine Binding Site target
Olanzapine Dopamine D1 receptor target
Olanzapine Muscarinic acetylcholine receptor M1 target
Olanzapine Muscarinic acetylcholine receptor M3 target
Olanzapine 5-hydroxytryptamine receptor 2A target
Olanzapine Dopamine D4 receptor target
Olanzapine Histamine H1 receptor target
Olanzapine Muscarinic acetylcholine receptor M4 target
Olanzapine Muscarinic acetylcholine receptor M2 target
Olanzapine Dopamine D2 receptor target
Olanzapine 5-hydroxytryptamine receptor 2C target
Olanzapine Dopamine D3 receptor target
Olanzapine Alpha-1B adrenergic receptor target
Olanzapine 阶段chrome P450 1A2 enzyme
Olanzapine 5-hydroxytryptamine receptor 3A target
Olanzapine 5-hydroxytryptamine receptor 6 target
Olanzapine Alpha-1A adrenergic receptor target
Olanzapine Dopamine D5 receptor target
Olanzapine Serum albumin carrier
Olanzapine Alpha-1-acid glycoprotein 1 carrier
Olanzapine Dimethylaniline monooxygenase [N-oxide-forming] 3 enzyme
Olanzapine 阶段chrome P450 2D6 enzyme
Olanzapine P-glycoprotein 1 transporter
Olanzapine 阶段chrome P450 2C19 enzyme
Olanzapine D(1) dopamine receptor target
Olanzapine Beta adrenergic receptor target
Olanzapine 5-hydroxytryptamine receptor 1 target
Olanzapine GABA(A) Receptor Benzodiazepine Binding Site target
Olanzapine 阶段chrome P450 2C9 enzyme
Olanzapine UDP-glucuronosyltransferase 1-4 enzyme
Olanzapine 阶段chrome P450 3A4 enzyme
Olanzapine 阶段chrome P450 3A Subfamily enzyme
Doxylamine Histamine H1 receptor target
Doxylamine Muscarinic acetylcholine receptor target
Doxylamine CYP2B protein enzyme
Doxylamine Nuclear receptor subfamily 1 group I member 3 target
Doxylamine Serum albumin carrier
Thiethylperazine Dopamine D2 receptor target
Promazine Dopamine D2 receptor target
Promazine 5-hydroxytryptamine receptor 2A target
Promazine 5-hydroxytryptamine receptor 2C target
Promazine Alpha-1A adrenergic receptor target
Promazine Muscarinic acetylcholine receptor M1 target
Promazine Histamine H1 receptor target
Promazine 阶段chrome P450 2C19 enzyme
Promazine 阶段chrome P450 1A2 enzyme
Promazine 阶段chrome P450 3A4 enzyme
Promazine 阶段chrome P450 2C9 enzyme
Promazine 阶段chrome P450 2D6 enzyme
Prochlorperazine Dopamine D2 receptor target
Prochlorperazine 阶段chrome P450 2D6 enzyme
Prochlorperazine Histamine H1 receptor target
Prochlorperazine Alpha-1 adrenergic receptors target
Prochlorperazine Alpha-2 adrenergic receptors target
Droperidol Dopamine D2 receptor target
Droperidol Alpha-1A adrenergic receptor target
Chlorpromazine Dopamine D2 receptor target
Chlorpromazine 5-hydroxytryptamine receptor 2A target
Chlorpromazine 阶段chrome P450 2D6 enzyme
Chlorpromazine Cholinesterase enzyme
Chlorpromazine 阶段chrome P450 1A2 enzyme
Chlorpromazine Serum albumin carrier
Chlorpromazine P-glycoprotein 1 transporter
Chlorpromazine Dopamine D1 receptor target
Chlorpromazine 5-hydroxytryptamine receptor 1A target
Chlorpromazine Alpha-1A adrenergic receptor target
Chlorpromazine Alpha-1B adrenergic receptor target
Chlorpromazine 阶段chrome P450 2E1 enzyme
Chlorpromazine 阶段chrome P450 3A4 enzyme
Chlorpromazine Histamine H1 receptor target
Chlorpromazine Potassium voltage-gated channel subfamily H member 2 target
Chlorpromazine D(1) dopamine receptor target
Chlorpromazine Dopamine D3 receptor target
Chlorpromazine Dopamine D4 receptor target
Chlorpromazine Dopamine D5 receptor target
Chlorpromazine 5-hydroxytryptamine receptor 2C target
Chlorpromazine 5-hydroxytryptamine 2 receptor target
Chlorpromazine Alpha-1 adrenergic receptors target
Chlorpromazine Alpha-2 adrenergic receptors target
Chlorpromazine Muscarinic acetylcholine receptor M1 target
Chlorpromazine Muscarinic acetylcholine receptor M3 target
Chlorpromazine Sphingomyelin phosphodiesterase target
Chlorpromazine Calmodulin target
Chlorpromazine alpha1-acid glycoprotein target
Chlorpromazine 5-hydroxytryptamine receptor 6 target
Chlorpromazine 5-hydroxytryptamine receptor 7 target
Chlorpromazine Histamine H4 receptor target
Chlorpromazine Bile salt export pump transporter
Nabilone Cannabinoid receptor 2 target
Nabilone Cannabinoid receptor 1 target
Nabilone 阶段chrome P450 2E1 enzyme
Nabilone 阶段chrome P450 2C8 enzyme
Nabilone 阶段chrome P450 2C9 enzyme
Nabilone 阶段chrome P450 3A4 enzyme
Nabilone 阶段chrome P450 2J2 enzyme
Haloperidol Dopamine D2 receptor target
Haloperidol Glutamate receptor ionotropic, NMDA 2B target
Haloperidol Dopamine D1 receptor target
Haloperidol 阶段chrome P450 1A2 enzyme
Haloperidol 阶段chrome P450 2D6 enzyme
Haloperidol 5-hydroxytryptamine receptor 2A target
Haloperidol Dopamine D3 receptor target
Haloperidol 阶段chrome P450 3A4 enzyme
Haloperidol 阶段chrome P450 3A5 enzyme
Haloperidol 阶段chrome P450 3A7 enzyme
Haloperidol P-glycoprotein 1 transporter
Haloperidol Carbonyl reductase [NADPH] 1 enzyme
Haloperidol UDP-glucuronosyltransferase 1-9 enzyme
Haloperidol 阶段chrome P450 2C19 enzyme
Haloperidol 阶段chrome P450 2C9 enzyme
Haloperidol Melanin-concentrating hormone receptor 1 target
Haloperidol Synaptic vesicular amine transporter target
Haloperidol 5-hydroxytryptamine receptor 2C target
Haloperidol Sigma non-opioid intracellular receptor 1 target
Haloperidol Histamine H1 receptor target
Haloperidol Muscarinic acetylcholine receptor M3 target
Haloperidol Alpha-1A adrenergic receptor target
Haloperidol Alpha-2A adrenergic receptor target
Haloperidol Alpha-2B adrenergic receptor target
Haloperidol Alpha-2C adrenergic receptor target
Haloperidol 5-hydroxytryptamine receptor 1A target
Haloperidol 5-hydroxytryptamine receptor 6 target
Haloperidol 5-hydroxytryptamine receptor 7 target
Haloperidol 阶段chrome P450 1A1 enzyme
Triflupromazine Dopamine D1 receptor target
Triflupromazine Dopamine D2 receptor target
Triflupromazine Muscarinic acetylcholine receptor M1 target
Triflupromazine Muscarinic acetylcholine receptor M2 target
Triflupromazine 5-hydroxytryptamine receptor 2B target
Triflupromazine P-glycoprotein 1 transporter
Triflupromazine Cholinesterase enzyme
Aprepitant Neurokinin 1 receptor target
Aprepitant 阶段chrome P450 3A4 enzyme
Aprepitant 阶段chrome P450 2C9 enzyme
Aprepitant 阶段chrome P450 2C19 enzyme
Dolasetron 5-hydroxytryptamine receptor 3A target
Dolasetron 阶段chrome P450 3A4 enzyme
Dolasetron 阶段chrome P450 2D6 enzyme
Dolasetron 阶段chrome P450 2C9 enzyme
Trifluoperazine Dopamine D2 receptor target
Trifluoperazine Alpha-1A adrenergic receptor target
Trifluoperazine Neuron-specific vesicular protein calcyon target
Trifluoperazine Xanthine dehydrogenase/oxidase enzyme
Trifluoperazine UDP-glucuronosyltransferase 1-4 enzyme
Trifluoperazine 阶段chrome P450 1A2 enzyme
Trifluoperazine P-glycoprotein 1 transporter
Trifluoperazine Calmodulin target
Trifluoperazine Troponin C, slow skeletal and cardiac muscles target
Trifluoperazine Protein S100-A4 target
Granisetron 5-hydroxytryptamine receptor 3A target
Granisetron 阶段chrome P450 3A4 enzyme
Granisetron 阶段chrome P450 1A1 enzyme
Ondansetron 5-hydroxytryptamine receptor 3A target
Ondansetron 阶段chrome P450 3A4 enzyme
Ondansetron 阶段chrome P450 1A2 enzyme
Ondansetron 阶段chrome P450 2D6 enzyme
Ondansetron 阶段chrome P450 3A5 enzyme
Ondansetron 阶段chrome P450 3A7 enzyme
Ondansetron 5-hydroxytryptamine receptor 4 target
Ondansetron 5-hydroxytryptamine receptor 1A target
Ondansetron 5-hydroxytryptamine receptor 1B target
Ondansetron Mu-type opioid receptor target
Ondansetron 阶段chrome P450 2C9 enzyme
Ondansetron 阶段chrome P450 2E1 enzyme
Methylprednisolone Glucocorticoid receptor target
Methylprednisolone 阶段chrome P450 3A4 enzyme
Methylprednisolone P-glycoprotein 1 transporter
Methylprednisolone 阶段chrome P450 3A Subfamily enzyme
Methylprednisolone 阶段chrome P450 2A6 enzyme
Methylprednisolone 阶段chrome P450 1B1 enzyme
Methylprednisolone 阶段chrome P450 2B6 enzyme
Methylprednisolone 阶段chrome P450 2C8 enzyme
Methylprednisolone 阶段chrome P450 2C9 enzyme
Methylprednisolone 阶段chrome P450 2C19 enzyme
Methylprednisolone Annexin A1 target
Methylprednisolone 20-ketosteroid reductase (20-hydroxysteroid dehydrogenase) enzyme
Methylprednisolone 11beta-hydroxysteroid dehydrogenase enzyme
Methylprednisolone Serum albumin carrier
Dimenhydrinate Histamine H1 receptor target
Cyclizine Histamine H1 receptor target
Cyclizine Estrogen sulfotransferase target
Cyclizine 阶段chrome P450 2C9 enzyme
Cyclizine Serum albumin carrier
Domperidone Dopamine D2 receptor target
Domperidone 阶段chrome P450 3A4 enzyme
Domperidone 阶段chrome P450 3A5 enzyme
Domperidone 阶段chrome P450 3A7 enzyme
Domperidone P-glycoprotein 1 transporter
Domperidone 阶段chrome P450 1A2 enzyme
Domperidone 阶段chrome P450 2B6 enzyme
Domperidone 阶段chrome P450 2C8 enzyme
Domperidone 阶段chrome P450 2D6 enzyme
Domperidone Dopamine D3 receptor target
Diphenidol Muscarinic acetylcholine receptor M2 target
Diphenidol Muscarinic acetylcholine receptor M1 target
Diphenidol Muscarinic acetylcholine receptor M3 target
Metoclopramide Muscarinic acetylcholine receptor M1 target
Metoclopramide Dopamine D2 receptor target
Metoclopramide 阶段chrome P450 2D6 enzyme
Metoclopramide 5-hydroxytryptamine receptor 4 target
Metoclopramide 5-hydroxytryptamine receptor 3A target
Metoclopramide 阶段chrome P450 3A4 enzyme
Metoclopramide 阶段chrome P450 1A2 enzyme
Metoclopramide P-glycoprotein 1 transporter
Metoclopramide Alpha-1-acid glycoprotein 1 carrier
Dexamethasone Glucocorticoid receptor target
Dexamethasone Annexin A1 target
Dexamethasone Nitric oxide synthase, inducible target
Dexamethasone Nuclear receptor subfamily 0 group B member 1 target
Dexamethasone 阶段chrome P450 3A4 enzyme
Dexamethasone 阶段chrome P450 3A5 enzyme
Dexamethasone 阶段chrome P450 3A7 enzyme
Dexamethasone Bile salt export pump transporter
Dexamethasone P-glycoprotein 1 transporter
Dexamethasone Canalicular multispecific organic anion transporter 1 transporter
Dexamethasone Solute carrier organic anion transporter family member 1A2 transporter
Dexamethasone ATP-binding cassette sub-family G member 2 transporter
Dexamethasone Steroid 17-alpha-hydroxylase/17,20 lyase enzyme
Dexamethasone 阶段chrome P450 1A1 enzyme
Dexamethasone 阶段chrome P450 2A6 enzyme
Dexamethasone 阶段chrome P450 2B6 enzyme
Dexamethasone 阶段chrome P450 2C19 enzyme
Dexamethasone 阶段chrome P450 2C8 enzyme
Dexamethasone 阶段chrome P450 2E1 enzyme
Dexamethasone 阶段chrome P450 3A43 enzyme
Dexamethasone 阶段chrome P450 4A11 enzyme
Dexamethasone Nuclear receptor subfamily 1 group I member 2 target
Dexamethasone 阶段chrome P450 11B1, mitochondrial enzyme
Dexamethasone Serum albumin carrier
Dexamethasone Corticosteroid 11-beta-dehydrogenase isozyme 2 enzyme
Dexamethasone Corticosteroid 11-beta-dehydrogenase isozyme 1 enzyme
Dexamethasone Solute carrier family 22 member 8 transporter
Alizapride Dopamine D2 receptor target
Dexanabinol Tumor necrosis factor target
Casopitant 阶段chrome P450 3A4 target
Casopitant Neurokinin 1 receptor target
Fosaprepitant 阶段chrome P450 3A4 enzyme
Fosaprepitant 阶段chrome P450 2C9 enzyme
Bromopride Dopamine D2 receptor target
Ramosetron 5-hydroxytryptamine receptor 3A target
Ramosetron 阶段chrome P450 1A2 enzyme
Peppermint oil 阶段chrome P450 1A2 enzyme
Peppermint oil 阶段chrome P450 3A4 enzyme
Tropisetron 5-hydroxytryptamine receptor 3A target
Vofopitant Neurokinin 1 receptor target
Palonosetron 5-hydroxytryptamine receptor 3A target
Palonosetron 阶段chrome P450 2D6 enzyme
Palonosetron 阶段chrome P450 3A4 enzyme
Palonosetron 阶段chrome P450 1A2 enzyme
Diphenhydramine Histamine H1 receptor target
Diphenhydramine 阶段chrome P450 2D6 enzyme
Diphenhydramine 阶段chrome P450 2C9 enzyme
Diphenhydramine 阶段chrome P450 2C19 enzyme
Diphenhydramine Solute carrier family 22 member 2 transporter
Diphenhydramine Solute carrier family 22 member 5 transporter
Diphenhydramine Prostaglandin G/H synthase 1 enzyme
Diphenhydramine Muscarinic acetylcholine receptor M2 target
Scopolamine Muscarinic acetylcholine receptor M1 target
Scopolamine Sucrase-isomaltase, intestinal target
Scopolamine Muscarinic acetylcholine receptor M2 target
Scopolamine Muscarinic acetylcholine receptor M3 target
Scopolamine Muscarinic acetylcholine receptor M4 target
Scopolamine Muscarinic acetylcholine receptor M5 target
Scopolamine Neuronal acetylcholine receptor subunit alpha-4 target
Scopolamine Neuronal acetylcholine receptor subunit beta-2 target
Scopolamine 阶段chrome P450 3A4 enzyme
Amisulpride Dopamine D2 receptor target
Amisulpride Dopamine D3 receptor target
Amisulpride 5-hydroxytryptamine receptor 7 target
Amisulpride 5-hydroxytryptamine receptor 2A target
Amisulpride Erythrocyte carrier
Amisulpride Multidrug and toxin extrusion protein 1 transporter
Amisulpride Multidrug and toxin extrusion protein 2 transporter
Amisulpride P-glycoprotein 1 transporter
Amisulpride ATP-binding cassette sub-family G member 2 transporter
Amisulpride 溶质载体家庭22个成员1 transporter
Amisulpride Mu-type opioid receptor target
Amisulpride Delta-type opioid receptor target
Amisulpride Kappa-type opioid receptor target
Alosetron 5-hydroxytryptamine receptor 3A target
Alosetron 阶段chrome P450 1A2 enzyme
Alosetron 阶段chrome P450 2C9 enzyme
Alosetron 阶段chrome P450 3A4 enzyme
Alosetron 阶段chrome P450 2E1 enzyme