Opiate Alkaloids

Name
Opiate Alkaloids
Accession Number
DBCAT000692
Description

Alkaloids found in OPIUM from PAPAVER that induce analgesic and narcotic effects by action upon OPIOID RECEPTORS.

Drugs
Drug Drug Description
Morphine An opioid agonist used for the relief of moderate to severe acute and chronic pain.
Codeine An opioid analgesic used to treat moderate to severe pain when the use of an opioid is indicated.
Hydromorphone An opioid analgesic used to treat moderate to severe pain when the use of an opioid is indicated.
Oxycodone An opioid used in the management of moderate to severe pain.
Dextromethorphan An NMDA receptor antagonist used to treat cases of dry cough.
Hydrocodone An opioid agonist used as an analgesic and antitussive agent.
Papaverine An alkaloid used to treat many types of smooth muscle spasms such as "vascular spasms" associated with acute myocardial infarction and angina pectoris, as well as "visceral spasms".
Naloxone An opioid receptor antagonist used to rapidly reverse an opioid overdose. Also included in some drug formulations as an abuse deterrent to prevent injection.
Noscapine A non-sedating isoquinoline alkaloid used primarily for its antitussive properties.
Drotaverine A phosphodiesterase-4 inhibitor used to alleviate gastrointestinal and genitourinary smooth muscle spasms.
Samidorphan A novel opioid-system modulator, similar to naltrexone, that functions primarily as a μ-opioid receptor antagonist in vivo and is used primarily in combination with antipsychotics to reduce their metabolic dysfunction-associated adverse effects.
Levallorphan For the complete or partial reversal of narcotic depression, including respiratory depression, induced by opioids.
部torphanol An opioid agonist-antagonist used to treat moderate to severe pain.
Pentazocine An analgesic used to treat moderate to severe pain.
Naltrexone A narcotic antagonist used in opioid overdose.
Nalbuphine An opioid agonist-antagonist used to treat pain, for pre and postoperative analgesia, and for analgesia in labor and delivery.
Levorphanol An opioid analgesic used to treat moderate to severe pain.
部prenorphine A partial opioid agonist used for management of severe pain that is not responsive to alternative treatments. Also used for maintenance treatment of opioid addiction.
Oxymorphone An opioid analgesic used in the management of moderate-to-severe pain and for analgesic therapies.
5-Methoxy-N,N-diisopropyltryptamine 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT) is a tryptamine derivative and shares many similarities with schedule I tryptamine hallucinogens such as alpha-ethyltryptamine, N,N-dimethyltryptamine, N,N-diethyltryptamine, bufotenine, psilocybin and psilocin. Since 1999, there has been a...
Dihydroetorphine Not Available
Diamorphine An opioid analgesic agent used in the relief of severe pain associated with surgical procedures, myocardial infarction or pain in the terminally ill and for the relief of dyspnea in acute pulmonary edema.
Ethylmorphine An opioid analgesic and antitussive agent used to reduce coughs caused by colds and lung infections in combination with codeine.
Cyprenorphine Not Available
Etorphine Etorphine is only available for its use in veterinary. This main usage is related to the immobilization of large mammals.
Desomorphine Not Available
Drotebanol Not Available
Diprenorphine Diprenorphine is indicated to reverse the effects of powerful opioids including etorphine and carfentanil, often used for tranquilizing large animals. This drug is not approved for use in humans.
Dihydrocodeine An opioid analgesic agent used for the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate.
Dihydromorphine Dihydromorphine is an opioid analgesic used for moderate to severe pain relief.
Nalmefene An opioid antagonist used to reduce alcohol consumption in adults with alcohol dependence and treat and prevent opioid overdose.
Morphine glucuronide Investigated for use/treatment in pain (acute or chronic).
Methylnaltrexone A μ-opioid antagonist used for the treatment of opioid-induced constipation in palliative patients that are inadequately responding to laxative therapy.
Naloxegol A peripherally-selective opioid antagonist used to treat opioid-induced constipation (OIC) in adult patients with chronic non-cancer pain.
Pholcodine An opioid antitussive used to suppress unproductive coughing.
Nalorphine Used to reverse opioid overdose.
Naldemedine An opioid antagonist used to to treat opioid-induced constipation.
Moxaverine Moxaverine has been investigated for the treatment of Retina, Ocular Physiology, and Regional Blood Flow.
Nicomorphine Not Annotated
Nalfurafine Not Annotated
Phenazocine Not Annotated
Dimemorfan Not Annotated
Loxicodegol Loxicodegol was developed as an opioid analgesic with low abuse potential for use in treating chronic pain . An application has been filed for FDA approval of Loxicodegol for use...
Dextrorphan Not Annotated
Sinomenine Not Annotated
Drugs & Drug Targets
Drug Target Type
Morphine Mu-type opioid receptor target
Morphine Delta-type opioid receptor target
Morphine Kappa-type opioid receptor target
Morphine P-glycoprotein 1 transporter
Morphine Cytochrome P450 2C8 enzyme
Morphine Cytochrome P450 3A4 enzyme
Morphine UDP-glucuronosyltransferase 2B7 enzyme
Morphine UDP-glucuronosyltransferase 1-1 enzyme
Morphine UDP-glucuronosyltransferase 1-8 enzyme
Morphine UDP-glucuronosyltransferase 2B15 enzyme
Morphine UDP-glucuronosyltransferase 2B4 enzyme
Morphine UDP-glucuronosyltransferase 1-3 enzyme
Morphine Lymphocyte antigen 96 target
Morphine Serum albumin carrier
Codeine Mu-type opioid receptor target
Codeine Delta-type opioid receptor target
Codeine Kappa-type opioid receptor target
Codeine Cytochrome P450 2D6 enzyme
Codeine Cytochrome P450 3A4 enzyme
Codeine 溶质载体家庭22个成员1 transporter
Codeine UDP-glucuronosyltransferase 2B7 enzyme
Codeine UDP-glucuronosyltransferase 2B4 enzyme
Hydromorphone Mu-type opioid receptor target
Hydromorphone Delta-type opioid receptor target
Hydromorphone Kappa-type opioid receptor target
Hydromorphone Cytochrome P450 2C9 enzyme
Hydromorphone UDP-glucuronosyltransferase 1-3 enzyme
Hydromorphone UDP-glucuronosyltransferase 2B7 enzyme
Hydromorphone Serum albumin carrier
Oxycodone Mu-type opioid receptor target
Oxycodone Kappa-type opioid receptor target
Oxycodone Delta-type opioid receptor target
Oxycodone Cytochrome P450 2D6 enzyme
Oxycodone Cytochrome P450 3A4 enzyme
Oxycodone Cytochrome P450 3A5 enzyme
Oxycodone Serum albumin carrier
Oxycodone alpha1-acid glycoprotein carrier
Dextromethorphan Sigma non-opioid intracellular receptor 1 target
Dextromethorphan Neuronal acetylcholine receptor subunit alpha-2 target
Dextromethorphan Sodium-dependent serotonin transporter target
Dextromethorphan Glutamate receptor ionotropic, NMDA 3A target
Dextromethorphan Cytochrome P450 2D6 enzyme
Dextromethorphan Cytochrome P450 3A4 enzyme
Dextromethorphan Cytochrome P450 3A7 enzyme
Dextromethorphan Cytochrome P450 2C9 enzyme
Dextromethorphan Cytochrome P450 2B6 enzyme
Dextromethorphan Cytochrome P450 2C19 enzyme
Dextromethorphan Membrane-associated progesterone receptor component 1 target
Dextromethorphan Neuronal acetylcholine receptor subunit alpha-3 target
Dextromethorphan Neuronal acetylcholine receptor subunit alpha-4 target
Dextromethorphan Neuronal acetylcholine receptor subunit beta-4 target
Dextromethorphan Neuronal acetylcholine receptor subunit beta-2 target
Dextromethorphan 神经乙酰胆碱受体亚单位级别alpha - 7 target
Dextromethorphan Mu-type opioid receptor target
Dextromethorphan Delta-type opioid receptor target
Dextromethorphan Kappa-type opioid receptor target
Dextromethorphan NADPH oxidase target
Dextromethorphan Sodium-dependent noradrenaline transporter target
Dextromethorphan UDP-glucuronosyltransferase 2B4 enzyme
Dextromethorphan UDP-glucuronosyltransferase 2B7 enzyme
Dextromethorphan UDP-glucuronosyltransferase 2B15 enzyme
Dextromethorphan UDP-glucuronosyltransferase 2B17 enzyme
Hydrocodone Mu-type opioid receptor target
Hydrocodone Delta-type opioid receptor target
Hydrocodone Cytochrome P450 3A4 enzyme
Hydrocodone Cytochrome P450 2D6 enzyme
Hydrocodone Cytochrome P450 2B6 enzyme
Hydrocodone Cytochrome P450 2C19 enzyme
Hydrocodone Sigma non-opioid intracellular receptor 1 target
Papaverine cAMP-specific 3',5'-cyclic phosphodiesterase 4B target
Papaverine cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A target
Papaverine Phosphodiesterase enzymes target
Naloxone Mu-type opioid receptor target
Naloxone Estrogen receptor alpha target
Naloxone Cyclic AMP-responsive element-binding protein 1 target
Naloxone Delta-type opioid receptor target
Naloxone Solute carrier organic anion transporter family member 1A2 transporter
Naloxone P-glycoprotein 1 transporter
Naloxone Kappa-type opioid receptor target
Naloxone Cytochrome P450 3A4 enzyme
Naloxone Serum albumin carrier
Naloxone Toll-like receptor 4 target
Naloxone Liver carboxylesterase 1 target
Naloxone UDP-glucuronosyltransferase 1-1 enzyme
Naloxone Cytochrome P450 2C18 enzyme
Naloxone Cytochrome P450 2C19 enzyme
Noscapine Sigma non-opioid intracellular receptor 1 target
Noscapine Cytochrome P450 2C9 enzyme
Noscapine Cytochrome P450 3A4 enzyme
Drotaverine cAMP-specific 3',5'-cyclic phosphodiesterase 4A target
Drotaverine Voltage-dependent L-type calcium channel target
Samidorphan Mu-type opioid receptor target
Samidorphan Kappa-type opioid receptor target
Samidorphan Delta-type opioid receptor target
Samidorphan Cytochrome P450 3A4 enzyme
Samidorphan Cytochrome P450 3A5 enzyme
Samidorphan Cytochrome P450 2C19 enzyme
Samidorphan Cytochrome P450 2C8 enzyme
Levallorphan Mu-type opioid receptor target
部torphanol Kappa-type opioid receptor target
部torphanol Mu-type opioid receptor target
部torphanol Delta-type opioid receptor target
Pentazocine Mu-type opioid receptor target
Pentazocine Kappa-type opioid receptor target
Pentazocine Sigma non-opioid intracellular receptor 1 target
Pentazocine P-glycoprotein 1 transporter
Naltrexone Mu-type opioid receptor target
Naltrexone Kappa-type opioid receptor target
Naltrexone Delta-type opioid receptor target
Naltrexone UDP-glucuronosyltransferase 1-1 enzyme
Naltrexone Sigma non-opioid intracellular receptor 1 target
Nalbuphine Kappa-type opioid receptor target
Nalbuphine Mu-type opioid receptor target
Nalbuphine Delta-type opioid receptor target
Levorphanol Mu-type opioid receptor target
Levorphanol Delta-type opioid receptor target
Levorphanol Kappa-type opioid receptor target
部prenorphine Kappa-type opioid receptor target
部prenorphine Mu-type opioid receptor target
部prenorphine Cytochrome P450 3A4 enzyme
部prenorphine Cytochrome P450 2D6 enzyme
部prenorphine P-glycoprotein 1 transporter
部prenorphine ATP-binding cassette sub-family G member 2 transporter
部prenorphine Cytochrome P450 2C9 enzyme
部prenorphine Cytochrome P450 3A5 enzyme
部prenorphine Cytochrome P450 2C8 enzyme
部prenorphine Cytochrome P450 3A7 enzyme
部prenorphine Delta-type opioid receptor target
部prenorphine Cytochrome P450 2C18 enzyme
部prenorphine Cytochrome P450 2C19 enzyme
部prenorphine Nociceptin receptor target
Oxymorphone Mu-type opioid receptor target
Oxymorphone Cytochrome P450 2D6 enzyme
Oxymorphone Delta-type opioid receptor target
Oxymorphone Cytochrome P450 3A4 enzyme
Diamorphine Mu-type opioid receptor target
Diamorphine Kappa-type opioid receptor target
Diamorphine Delta-type opioid receptor target
Diamorphine Liver carboxylesterase 1 target
Diamorphine Thyroxine-binding globulin carrier
Ethylmorphine Cytochrome P450 2D6 enzyme
Ethylmorphine NADPH--cytochrome P450 reductase enzyme
Ethylmorphine Mu-type opioid receptor target
Ethylmorphine Cytochrome P450 2B6 enzyme
Ethylmorphine Cytochrome P450 3A4 enzyme
Etorphine E3 ubiquitin-protein ligase TRIM13 target
Etorphine Pro-opiomelanocortin target
Etorphine Mu-type opioid receptor target
Etorphine Delta-type opioid receptor target
Etorphine Kappa-type opioid receptor target
Etorphine Nociceptin receptor target
Diprenorphine E3 ubiquitin-protein ligase TRIM13 target
Diprenorphine Delta-type opioid receptor target
Diprenorphine Kappa-type opioid receptor target
Diprenorphine Mu-type opioid receptor target
Dihydrocodeine Cytochrome P450 2D6 enzyme
Dihydrocodeine Cytochrome P450 3A4 enzyme
Dihydromorphine E3 ubiquitin-protein ligase TRIM13 target
Dihydromorphine Pro-opiomelanocortin target
Dihydromorphine Mu-type opioid receptor target
Dihydromorphine Delta-type opioid receptor target
Dihydromorphine Kappa-type opioid receptor target
Nalmefene Mu-type opioid receptor target
Nalmefene Kappa-type opioid receptor target
Nalmefene Delta-type opioid receptor target
Nalmefene UDP-glucuronosyltransferase 2B7 enzyme
Nalmefene UDP-glucuronosyltransferase 1-3 enzyme
Nalmefene UDP-glucuronosyltransferase 1-8 enzyme
Nalmefene Cytochrome P450 3A4 enzyme
Nalmefene Cytochrome P450 3A5 enzyme
Morphine glucuronide Mu-type opioid receptor target
Morphine glucuronide Delta-type opioid receptor target
Morphine glucuronide Kappa-type opioid receptor target
Methylnaltrexone Mu-type opioid receptor target
Methylnaltrexone Kappa-type opioid receptor target
Naloxegol Cytochrome P450 3A4 enzyme
Naloxegol Cytochrome P450 2D6 enzyme
Naloxegol Cytochrome P450 2C19 enzyme
Naloxegol Mu-type opioid receptor target
Pholcodine Mu-type opioid receptor target
Pholcodine Kappa-type opioid receptor target
Pholcodine Delta-type opioid receptor target
Naldemedine Cytochrome P450 3A Subfamily enzyme
Naldemedine UDP-glucuronosyltransferase 1-3 enzyme
Naldemedine Mu-type opioid receptor target
Naldemedine Delta-type opioid receptor target
Naldemedine Kappa-type opioid receptor target
Naldemedine ATP-binding cassette sub-family B member 5 transporter
Loxicodegol Mu-type opioid receptor target
Loxicodegol Delta-type opioid receptor target
Loxicodegol Kappa-type opioid receptor target
Loxicodegol P-glycoprotein 1 transporter